Unit of Human Biology and Genetics, Department of Biological Sciences, School of Science, University of Tokyo

東京大学大学院 理学系研究科 生物科学専攻 / 広域科学大講座:人類進化システム学 /
人類科学大講座:人類生物学・遺伝学研究室

東京大学大学院
            理学系研究科 生物科学専攻
            広域科学大講座:人類進化システム学
            人類科学大講座:人類生物学・遺伝学研究室

3. Patho-anthropology - 病理人類学

Patho-anthropologyある地域や集団に、特異的あるいは高頻度に見いだされる疾病の人類学的背景を調べています。特に、ウイルスという身近(?)な寄生体が関与している疾病に興味を持っており、宿主と病原体の両方からのアプローチを試みています。このような寄生体を対象とすることによって、これまでの人類学とはひと味違った研究を目指しています。具体的には、Epstein-Barrウイルスが関与している細胞増殖疾患である上咽頭癌・末梢Tリンパ腫におけるウイルスの系統と動態、宿主の生物学的背景を調べています。Papillomaウイルス関連疾患では子宮頚癌を扱います。また、おサルでもウイルス感染を調べ、系統や来歴の検討をしています。

参考文献

EE-55. Natphopsuk, S., Settheetham-Ishida, W., Sophida Phuthong, S. and Ishida, T. Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand. Asian Pacific J. Cancer Prev., 2016, 17: 739-742.
EE-54. Natphopsuk, S., Settheetham-Ishida, W., Settheetham, D. and Ishida, T. Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand. Asian Pacific J. Cancer Prev., 2015, 16: 1935-1937.
EE-53. Natphopsuk, S., Settheetham-Ishida, W., Pientong, C., Sinawat, S., Yuenyao, P. and Ishida, T. Human papillomavirus genotype and cervical cancer in Northeast Thailand. Asian Pacific J. Cancer Prev., 2013, 14: 6961-6964.
EE-52. Sakae, C., Natphopsuk, S., Settheetham-Ishida, W. and Ishida, T. Low prevalence of Toxoplasma gondii infection among women in Northeastern Thailand. Journal of Parasitology, 2013, 99: 172-173.
EE-51. Natphopsuk, S., Settheetham-Ishida, W., Sinawat, S., Pientong, C., Yuenyao, P. and Ishida, T. Risk factors for cervical cancer in northeastern Thailand: detailed analyses for the sexual and smoking behaviors. Asian Pacific J. Cancer Prev., 2012, 13: 5489-5495.
EE-50. Yamamoto, H., Suzuki, J., Matsuda, A., Ishida, T., Ami, Y., Suzaki, Y., Adachi, I., Wakita, T., Takeda, N. and Li, T.-C. Hepatitis E Outbreak in Monkey Facility, Japan. Emerging Infectious Diseases, 2012, 18: 2032-2034.
EE-49. Sakae, C. and Ishida, T. Direct evidence for Toxoplasma gondii infection in a wild Japanese serow (Capricornis crispus) from mainland Japan. J. Parasitology, 2012, 98: 224-225.
EE-48. Settheetham-Ishida, W., Yuenyao, P., Natphopsuk, S., Settheetham, D. and Ishida, T. Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand. Asian Pacific J. Cancer Prev., 2011, 12: 963-966.
EE-47. Kietthubthew, S., Wickliffe, J., Sriplung, H., Ishida, T., Chonmaitree, T. and Au, W. Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand Int. J. Hyg. Environ. Health, 2010, 213: 146–152.
EE-46. Settheetham-Ishida, W., Yuenyao, P., Kularbkaew, C., Settheetham, D. and Ishida, T. Glutathione S-transferase (GSTM1 and GSTT1) Polymorphisms in Cervical Cancer in Northeastern Thailand. Asian Pacific J Cancer Prev, 2009, 10: 365-368.
EE-45. Tiwawech, D., Chindavijak, S., Karalak, A. and Ishida, T. Real-Time PCR Assay for Rapid Detection of GSTM1 Polymorphism in Nasopharyngeal Carcinoma Patients. Asian Pacific J Cancer Prev, 2008, 9: 233-238.
EE-44. Tiwawech, D., Chindavjiak, S., Karalak, A. and Ishida, T. Detection of p53 codon 72 gene polymorphism in patients with oral canser. Thai Cancer Journal, 2008, 28: 24-33.
EE-43. Nagao, Y., Kimura-Sato, M., Chavalitshewinkoon-Petmitr, P., Thongrungkiat, S., Wilairatana, P., Ishida, T., Tan-Ariya, P., Brian de Souza, J., Krudsood, S. and Looareesuwan, S. Suppression of Plasmodium falciparum by serum collected from case of Plasmodium vivax infection. Malaria Journal, 2008, 7: 113-120.
EE-42. Tiwawech, D., Srivatanakul, P., Karaluk, A. and Ishida, T. Association between EBNA2 and LMP subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais. Journal of Clinical Virology, 42: 1-6.
EE-41. Tiwawech, D., Chindvjak, S., Karalak, A. and Ishida, T. Detection of GSTM1 Polymorphism in Patient with Nasopharyngeal Carcinoma by Real-Time PCR. Thai Cancer Journal, 28: 83-92.
EE-40. Suwiwat, S., Pradutkanchana, J., Ishida, T. and Mitarnun, W. Quantitative analysis of cell-free Epstein-Barr virus DNA in the plasma of patients with perioheral T-cell and NK-cell lymphomas and peripheral T-cell proliferative diseases. Journal of Clinical Virology, 40: 277-283.
EE-39. Settheetham-Ishida, W. and Ishida, T. Cervical Cancer in Northeastern Thailand. in: New Research on Cervical Cancer. ed. G.Z. Rolland, Nova Science Publishers, Inc., New York, pp 217-232 (2007).
EE-38. Settheetham-Ishida, W., Yuenyao, P., Tassaneeyakul, V., Kanjanavirojkul, N., Thawmor, A., Kularbkaew, C., Hahvajanawong, C., Settheetham, D., Wattanathorn, J., Kashima, T. and Ishida, T. Selected risk factors, human papillomavirus infection snd p53 codon 72 polymorphism in patients with squamous intraein pithelial lesion in Northeastern Thailand. Asian Pacific Journal of Cancer Prevention, 2006, 7:113-118.
EE-37. Saechan, V., Mori, A., Mitarnun, W., Settheetham-Ishida, W. and Ishida, T. Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity. Journal of Clinical Virology, 2006, 36:119-125.
EE-36. Tiwawech, D., Srivatanakul, P., Karaluk, A. and Ishida, T. Cytochrome P450 2A6 gene polymorphism in nasopharyngeal carcinoma. Cancer Letters, 2006, 241:135-141.
EE-35. Kimura, M., Soemantri, A., Siswanto, E. and Ishida, T. Ovalocytosis without band 3 gene 27-bp deletion and malaria infection. Anthropological Science, 2006, 114: 161-164.
EE-34. Kietthubthew, S., Sriplung, H., Au, W. and Ishida, T. Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. International Journal of Environmental Health, 2006, 209: 21-29.
EE-33. Tiwawech, D., Srivatanakul, P., Karaluk, A. and Ishida, T. Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma. Asian Pacific Journal of Cancer Prevention, 2005, 6: 270-275.
EE-32. Shimizu, H., Tamam, M., Soemantri, A. and Ishida, T. Glucose-6-phosphate dehydrogenase (G6PD) deficiency and Southeast Asian ovalocytosis in asymptomatic Plasmodium carriers in Sumba island, Indonesia. Journal of Human Genetics, 2005, 50: 420-424.
EE-31. Settheetham-Ishida, W., Kanjanavirojikul, N., Kularbkaew, C., Ishida, T. Human Papillomavirus Genotypes and the p53 Codon 72 Polymorphism in Cervical Cancer of Northeastern Thailand. Microbiol.Immunol., 2005, 49: 417-421.
EE-30. Okura, S., Yamashita, M., Ishida, T., Babu, P.G., Koyanagi, Y., Yamamoto, N., Miura, T. and Hayami, M. Phylogenetic heterogeneity of new HTLV type 1 isolates from southern India in subgroup A. AIDS Res. Hum. Retroviruses, 2005, 21: 325-330.
EE-29. Settheetham-I., W., Singto, Y., Kanjanavirojkul, N., Chatchawan, U., Yuenyao, P., Setthetham, D. and Ishida, T. Risk factors for HPV infection in Northeastern Thai women with cervical carcinoma. Asian Pacific Journal of Cancer Prevention, 2004, 5: 383-386.
EE-28. Nishioka, T., Soemantri, A., Ishida, T. mtDNA/nDNA ratio in 14484 LHON mitochondrial mutation carriers. Journal of Human Genetics, 2004, 49: 701-705.
EE-27. Suzuki, J., Goto, S., Kato, A., Hashimoto, C., Miwa, N., Takao, S., Ishida, T., Fukuoka, A., Nakayama, H., Doi, K. and Isowa, K. Malignant NK/T-cell lymphoma associated with simian Epstein-Barr virus infection in a Japanese macaque (Macaca fuscata). Experimental Animals, 2005, 54: 101-105.
EE-26. Mitarnun, W., Saechan, V., Suwiwat, S., Pradutkanchana, J., Takao, S. and Ishida, T. Hepatic cytotoxic T-cell infiltrates in patients with peripheral T-cell proliferative diseases/lymphomas: clinicopathological and molecular analysis. Pathology International, 2004, 54: 819-829.
EE-25. Mitarnun, W., Pradutkanchana, J. and Ishida, T. Epstein-Barr virus-associated nodal malignant lymphoma in Thailand. Asian Pacific Journal of Cancer Prevention, 2004, 5: 268-272.
EE-24. Settheetham-I., W., Singto, Y., Yuenyao, P., Tassaneeyakul, W., Kanjanavirojkul, N. and Ishida, T. Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeast Thailand. Cancer Letters, 2004, 210: 205-211.
EE-23. Mitarnun, W., Saechan, V., Pradutkanchana, J., Suwiwat, S., Takao, S. and Ishida, T. Epstein-Barr virus-associated peripheral T-cell lymphoma with gastrointestinal tract involvement in Southern Thailand. J. Med. Assoc. Thailand, 2003, 86: 816-828.
EE-22. Kietthubthew, S., Sriplung, H., Au, W.W. and Ishida, T. The p53 codon 72 polymorphism and risk of oralcancer in Southern Thailand. Asian Pacific Journal of Cancer Prevention, 2003, 4: 209-214.
EE-21. Tiwawech, D., Srivatanakul, P., Karaluk, A. and Ishida, T. Significance of plasma IgA and IgG antibodies to Epstein-Barr virus early and viral capsid antigens in Thai nasopharyngeal carcinoma. Asian Pacific Journal of Cancer Prevention, 2003, 4: 113-118.
EE-20. Nishioka, T., Tasaki, M., Soemantri, Ag., Dyat M., Susanto, J.C., Tamam, M., Sudarmanto, B. and Ishida, T. Leber’s hereditary optic neuropathy with 14484 mutation in Central Java, Indonesia. Journal of Human Genetics, 2003, 48: 385-389.
EE-19. Tiwawech, D., Srivatanakul, P., Karaluk, A. and Ishida, T. The p53 codon 72 polymorphism in Thai nasopharyngeal carcinoma. Cancer Letters, 2003, 198: 69-75.
EE-18. Sugauchi, F., Orito, E., Ichida, T., Kato, H., Sakugawa, H., Kakumu, S., Ishida, T., Chutaputti, A., Lai, C.-L., Gish, R.G., Ueda, R., Miyakawa, Y. and Mizokami, M. Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C. Gastroenterology, 2003, 124: 925-932.
EE-17. Mori, A., Takao, S., Pradutkanchana, J., Kietthubthew, S., Mitarnun, W. and Ishida, T. High tumor necrosis factor-a levels in the patients with Epstein-Barr virus-associated peripheral T-cell proliferative disease/lymphoma. Leukemia Res. 2003, 27: 493-498.
EE-16. Kantaputra, P.N., Yamasaki, K., Ishida, T., Kishino, T. and Niikawa, N. A. dominantly inherited malformation syndrome with short stature, upper limb anomaly, minor craniofacial anomalies, and absence of TBX5 mutations: report of a Thai family. American Journal of Medical Genetics, 2002, 111: 301-306.
EE-15. Mitarnun, W., Suwiwat, S., Pradutkanchana, J., Saechan, V., Takao, S. and Ishida, T. Epstein-Barr virus-associated non-hodgkin's lymphoma of B-cell origin, Hodgikin's Disease, acute leukemia, and systemic lupus erythematosus: a serologic and molecular analysis. J. Med. Assoc. Thailand, 2002, 85: 552-559.
EE-14. Kimura, M., Soemantri, Ag. and Ishida, T. Malaria species and Southeast Asian ovalocytosis defined by a 27-bp deletion in the erythrocyte band 3 gene. Southeast Asian Journal of Tropical Medicine and Public Health, 2002, 33: 4-6.
EE-13. Sugauchi, F., Orito, E., Ichida, T., Kato, H., Sakugawa, H., Kakumu, S., Ishida, T., Chutaputti, A., Lai, C.-L., Ueda, R., Miyakawa, Y. and Mizokami, M. Hepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene. Journal of Virology, 2002, 76: 5985-5992.
EE-12. Singh, N.B., Takao, S. and Ishida, T. Serological survey for the infection of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and human T-lymphotropic virus-1 among isolated ethnic groups in Nepal. Anthropological Science, 2002, 110: 179-183.
EE-11. Mitarnun, W., Suwiwat, S., Pradutkanchana, J., Saechan, V., Ishida, T., Takao, S. and Mori, A. Epstein-Barr Virus-Associated Peripheral T-cell and NK-cell Proliferative Disease/Lymphoma: A Clinicopathologic, Serologic and Molecular analysis. Americal Journal of Hematology, 2002, 70: 31-38.
EE-10. Ishida, T., Takao, S., Settheetham-I., W., and Tiwawech, D. Prevalence of hepatitis B and C virus infection in rural ethnic populations of northern Thailand. Journal of Clinical Virology, 2002, 24: 31-35.
EE-9. Yamashita, M., Ishida, T., Ohkura, S., Miura, T. and Hayami, M. Phylogenetic characterization of a new HTLV-1 from the Ainu in Japan. AIDS Research and Human Retroviruses, 2001, 17: 783-787.
EE-8. Ishida, T., Appassakij H., Takao, S., Settheetham-I, W., Tiwawech, D. and Duangchan, P. Human T-lymphotropic retrovirus type-1 in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health, 2000, 31-s1: 143-145.
EE-7. Takao, S., Ishida, T., Bhatia, K.K. Soemantri, Ag., Saha, N. and O.W. Kayame. Seroprevalence of human T-lymphotropic virus type 1 in Papua New Guinea and Irian Jaya measured using different Western blot criteria. Journal of Clinical Virology, 2000, 16: 129-133.
EE-6. Fujimoto, M., Kantaptra, P., Ikegawa, S., Fikushima, Y., Sonta, S., Matsuo, M., Ishida, T., Matsumoto, T., Kondo, S., Tomita, H., Deng, H.-X., Ventrudo, V., Takagi, T., Nakamura, Y. and Niikawa, N. The gene for mesomelic dysplasia Kantaptra type is mapped to chromosome 2q24-32. Journal of Human Genetics, 1998, 43: 32-36.
EE-5. Tiwawech, D. and Ishida, T. Presence of IgA and IgG antibodies against Epstein-Barr virus early antigen in Thai nasopharyngeal cancer patients. Thai Cancer Journal, 1996, 41: 209-214.
EE-4. Kondo, Y., Mizokami, M., Nakano, T., Kato, T., Ueda, R., Mukaide, M., Hikiji, K., Ishida, T., Dorjsuren, D., Dashnyam, B. and Oyunsuren T. Plevalence and molecular epidemiology of GB virus C/Hepatitis G virus infection in Mongolia. Journal of Medical Virology, 1997, 52: 143-148.
EE-3. Babu, P.G., Ishida, T., Nesadoss, J. and John, T.J. Prevalence of HTLV-1/2 antibody in HIV seropositive and HIV seronegative STD patients in Vellore region in Southern India. Scandinavian Journal of Infectious Diseases, 1995, 27: 105-108.
EE-2. Ishida, T. Human T-lymphotropic retrovirus type-1 (HTLV-1) and its distribution in Asian populations. Southeast Asian Journal of Tropical Medicine and Public Health, 1995, 26 (Suppl.): 182-189.
EE-1. Settheetham, W. and Ishida, T. Study of genotoxic effects of antidiarrheal medicinal herbs on human cells in vitro. Southeast Asian Journal of Tropical Medicine and Public Health, 1995, 26 (Suppl.): 306-310.

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