1. Hominization - ヒト化
集団レベルでは、繁殖戦略・雑種形成と生殖隔離・種内変異に興味を持っており、行動観察と分子レベルとの統合を目指します。ゾウ・チンパンジー・テナガザルを対象とした、比較ゲノムの探索を開始しました。下記の病理人類学と関連し、サルの疾病を調べ、モデル化の検討もしています。これまで、細胞レベルを中心とした、加齢、癌化、ゲノム安定性等についても研究してきました。
参考文献
| PH-48. | Matsudaira, K. and Ishida, T. Complete mitochondrial genome of Macaca mulatta from bangladesh. Archivio per l'Antropologia e la Ethnologia, 2020, 150: 59-65. |
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| PH-47. | Tolomeo, D., Capozzi, O., Chiatante, G., Sineo, L., Ishida, T., Archidiacono, N., Rocchi, M. and Stanyon, R. Eight million years of maintained heterozygosity in chromosome homologs of cercopithecine monkeys. Chromosoma, 2020, 129: 57-67. |
| PH-46. | Kutsukake, N., Teramoto, M., Honma, S., Mori, Y., Ikeda, K., Yamamoto, R., Ishida, T. and Hasegawa, T. Behavioural and hormonal changes during group formation by male chimpanzees. Behaviour, 2019, 156: 109-129. |
| PH-45. | Isshiki, M. and Ishida, T. Molecular Evolution of the semenogelin 1 and 2 and mating system in gibbons. Am. J. Phys. Anthrop. 2019, 168: 364-369. |
| PH-44. | Kutsukake, N., Teramoto, M., Honma, S., Mori, Y., Ikeda, K., Yamamoto, R., Ishida, T. and Hasegawa, T. The presence of females induces elevated cortisol levels in an alpha male: experimental evidence in chimpanzees. Am. J. Phys. Anthrop. 2018, 167: 327-336. |
| PH-43. | Matsudaira, K., Ishida, T., Malaivijitnond, S., Reichard, U.H. Short dispersal distance of males in a wild white-handed gibbon (Hylobates lar) population. Am. J. Phys. Anthrop. 2018, 167: 61-71. |
| PH-42. | Matsudaira, K., Hamada, Y., Bunlungsup, S., Ishida, T., San, A.M., Malaivijitnond, S. Whole mitochondrial genomic and Y-chromosomal phylogenies of Burmese long-tailed macaque (Macaca fascicularis aurea) suggest ancient hybridization between fascicularis and sinica species groups. Journal of Heredity. 2018, 109: 360-371. |
| PH-41. | Saitou, M., Satta, Y., Gokcumen, O., Ishida, T. Complex evolution of the GSTM gene family involves sharing of GSTM1deletion polymorphism in humans and chimpanzees. BMC Biology DOI: 10.1186/s12864-018-4676-z |
| PH-40. | Capozzi O; Stanyon R; Archidiacono N; Ishida T; Romanenko SA; Rocchi M. Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation. Scientific Reports. 2018, 8(1):3250 |
| PH-39. | Chiatante, G., Capozzi, O., Svartman, M., Perelman, P., Centrone, L., Romanenko, S.S., Ishida, T., Valeri, M., Roelke-Parker, M.E. and Stanyon, R. Centromere repositioning explains fundamental number variability in the New World monkey genus Saimiri. Chromosoma, 2017, 126:519-529. |
| PH-38. | Dumas, F., Sineo, L. and Ishida, T. Identificazione tassonomica di Aotus (Platyrrhinae) mediante la citogenetica. Journal of Biological Research, 2015, 88: 5161. |
| PH-37. | Sri Kantha, S., Kuraishi, T., Hattori, S., Ishida, T., Kiso, Y., Kai, C. and Suzuki, J. Behavioral Sleep of Captive Owl Monkey (Aotus lemurinus) in Amami Oshima, Japan. IMJ 2015, 22-26. |
| PH-36. | Ono, E., Suzuki, J. and Ishida, T. Spectrocolourimetry Visualized Differences in Sexual Skin Colouration in Macaques Folia Primatologica , 2015, 86: 178-186. |
| PH-35. | Matsudaira, K. and Ishida, T. Development of Y-chromosomal Polymorphic Markers in Two Gibbon Species (Hylobates lar and Hylobates pileatus). Jpn. J. Zoo. Wild Anim. Med. , 2015 20(1):15-19. |
| PH-34. | Barelli, C., Matsudaira, K., Wolf, T., Roos, C., Heistermann, M., Hodges, K., Ishida, T., Malaivijitnond, S. and Reichard, U.H. Extra-pair paternity confirmed in wild white-handed gibbons. American Journal of Primatology, 2013, 75: 1185-1195. |
| PH-33. | Matsudaira, K., Reichard, U., Malavijitnond, S. and Ishida, T. Molecular evidence for the introgression between Hylobates lar and H. pileatus in the wild. Primates, 2013, 54: 33-37. |
| PH-32. | Kutsukake, N., Teramoto, M., Homma, S., Mori, Y., Matsudaira, K., Kobayashi, H., Ishida, T., Okanoya, K., and Hasegawa, T. Individual variation in behavioural reactions to unfamiliar conspecific vocalisation and hormonal underpinnings in male chimpanzees. Ethology, 118: 269-280. |
| PH-31. | Ohtani, H., Nakajima, T., Akari, H., Ishida, T. and Kimura, A. Molecular evolution of immunoglobulin superfamily genes in primtes. Immunogenetics, 2011:63: 417-428. |
| PH-30. | Nakayama, K., Shotake, T., Takenaka, O. and Ishida, T. Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macaques. Journal of Mammalian Evolution, 2010, 17: 211-214.. |
| PH-29. | Yamamoto, R., Teramoto, M., Hayasaka, I., Ikeda, K., Hasegawa, T. and Ishida, T. Reactivation of lymphocryptovirus (EBVcmp) and the dominance in chimpanzees. Journal of General Virology, 2010, 91: 2049-2053.. |
| PH-28. | Matsudaira, K. and Ishida, T. Phylogenetic relationships and divergence dates of the whole mitochondrial genome sequences among three gibbon genera. Molecular Phylogenetics and Evolution, 2010, 55: 454-459. |
| PH-27. | Kutsukake, N., Ikeda, K., Honma, S., Teramoto, M., Mori, Y., Hayasaka, I., Yamamoto, R., Ishida, T., Yoshikawa, Y. and Hasegawa, T. Validation of Salivary Cortisol and Testosterone Assays in Chimpanzees by Liquid Chromatography-Tandem Mass Spectrometry. American Journal of Primatology, 2009, 71: 696-706. |
| PH-26. | Nakajima, T., Ohtani, H., Satta, Y., Uno, Y., Akari, H., Ishida, T. and Kimura, A. Natural selection in the TRL-related genes in the course of primate evolution. Immunogenetics, 2008, 60: 727-735. |
| PH-25. | Nakayama, K., Shotake, T., Takenaka, O. and Ishida, T. Variation of the melanocortin 1 receptor gene in the macaques. American Journal of Primatology, 2008, 70: 778-785. |
| PH-24. | Nakayama, K. and Ishida, T. Alu mediated 100kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes. Genome Research, 2006, 16: 485-490. |
| PH-23. | Kamio, K., Matsushita, I., Hijikata, M., Tanaka, G., Nakata, K., Ishida, T., Tokunaga, K., Kobashi, Y., Taguchi, Y., Homma, S., Nakata, K., Azuma, A., Kudoh, S. and Keicho, N. Promoter analysis and aberrant expression of MUC5B gene in diffuse panbronchiolitis. Am. J. Respir. Crit. Care Med., 2005, 171: 949-957. |
| PH-22. | Tanabe, H., Kupper, K., Ishida, T., Neusser, M. and Mizusawa, H. Inter- and intra-specific gene-density correlated radial chromosome territory arrangements are conserved in Old World monkeys. Cytogenetics and Genome Research, 2005, 108: 255-261. |
| PH-21. | Kutsukake, N. and Castles, D.L. Reconciliation and post-conflict third-party affiliation among wild chimpanzees in the Mahale Mountains, Tanzania. Primates, 2004, 45: 157-165. |
| PH-20. | Nakajima, T., Wooding, S., Sakagami, T., Emi, M., Tokunaga, K., Tamiya, G., Ishigami, T., Umemura, S., Munkhbat, B., Jin, F., Guan-jun, J., Hayasaka, I., Ishida, T., Saito, N., Pavelka, K., Lalouel, J.-M., Jorde, L.B. and Inoue, I. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in worldwide chromosomes. American Journal of Human Genetics, 2004, 74: 898-916. |
| PH-19. | Suto, Y., Ishida, T. and Hirai, M. Multicolor karyotyping of six Old World monkey species. Cytologia, 2003, 68: 431-436. |
| PH-18. | Tachikui, H., Nakajima, T., Saitou, N., Hayasaka, I., Ishida, T. and Inoue, I. Lineage specific homogenization of the polyubiquitin gene among human and great apes. Molecular Biology and Evolution, 2003, 57: 737-744. |
| PH-17. | Suto, Y., Ishikawa, Y., Hyodo, H., Ishida, T., Kasai, F., Tanoue, T., Hayasaka, I., Uchikawa, M., Juji, T. and Hirai, M. Gene arrangement at the Rhesus blood group locus of chimpanzees detected by fiber-FISH. Cytogenetic and Genome Research, 2003, 101: 161-165. |
| PH-16. | Sugawara, H., Harada, N., Ida, T., Ishida, T., Ledbetter, D.H., Yoshiura, K., Ohta, T., Kishino, T., Niikawa, N. and Matsumoto, N. Complex low-copy repeats associated with a common polymorphic inversion at human chromosome 8p23. Genomics, 2003, 82: 238-244. |
| PH-15. | Hohjoh, H., Ohashi, J. and Takasu, M., Nishioka, T., Ishida, T. and Tokunaga, K. Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species. Immunogenetics, 2003, 54: 856-861. |
| PH-14. | Shimizu, Y., Suzuki, J., Terao, K. and Ishida, T. In vitro aging of macaque adherent cells: similar pattern of cellular aging between human and macaque. Mechanisms of Ageing and Development, 2003, 124: 243-250. |
| PH-13. | Shimizu, Y. and Ishida, T. Spontaneous establishment of a novel Japanese macaque cell line. In Vitro Cellular & Developmental Biology-animal, 2002, 38: 311-313. |
| PH-12. | Shimizu, Y. and Ishida, T. Somatic mutations in the p53 gene account for the extension of replicative life-span of macaque cells. Biochem. Biophys. Res. Commun., 2002, 295: 664-650. |
| PH-11. | Dan, I., Watanabe, N.M., Kajikawa, E., Ishida, T., Pandey, A. and Kusumi, A. Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. Nucleic Acid Research, 2002, 30: 2906-2910. |
| PH-10. | Kimura, M. and Ishida, T. Chimpanzee Band 3 protein polymorphism and the origin of the band 3 Memphis in humans. Folia Primatologica, 2001, 72: 298-300. |
| PH-9. | Kimura, R. and Ishida, T. The human SDF-1 gene polymorphism is located on a mutational hotspot that was identified by the hominoid genome study. Human Biology, 2001, 73: 891-895. |
| PH-8. | Noda, R., Kim, C.G., Takenaka, O., Ferrell, R.E., Tanoue, I., Hayasaka, I., Ueda, S., Ishida, T. and Saitou, N. Mitochondrial 16S rRNA sequence diversity of hominoids. Journal of Heredity, 2001, 92: 490-496. |
| PH-7. | Suzuki, J. and Ishida, T. Age changes in plasma IGF-1 concentration in free-ranging Japanese macaques (Macaca fuscata). Journal of Medical Primatology, 2001, 30: 174-178. |
| PH-6. | 清水裕子 マカクの付着系細胞における in vitro 加齢変化. 霊長類研究 2000, 16: 77-85. |
| PH-5. | Pranomo ZAD, Takeshima, Y., Surono, A., Ishida, T. and Matsuo, M. A novel cryptic exon in intron 2 of the dystrophin gene evolved from intron by creating consensus sequences for splicing in different stages of the anthropoid evolution. Biochem. Biophys. Res. Commun., 2000, 267: 321-328. |
| PH-4. | Bigoni, F., Koehler, U., Stanyon, R., Ishida, T. and Wienberg, J. Fluorescence in situ hybridization establishes homology between human and silvered leaf monkey chromosomes, reveals reciprocal translocations between chromosomes homologous to human Y/5, 1/9, and 6/16, and delineates an X1X2Y1Y2/X1X1X2X2 sex-chromosome system. American Journal of Physical Anthropology, 1997, 102: 315-27. |
| PH-3. | Settheetham, W., Malaivijinond, S. and Ishida, T. Changes in serum immunoglobulin levels among cynomolgus monkeys with long term morphine treatment. Srinakharin Medical Journal, 1996, 11: 57-63. |
| PH-2. | Tanabe, H., Ishida, T., Ueda, S., Sofuni, T. and Mizusawa, H. Molecular anatomy of human chromosome 9: Comparative mapping of the immunoglobulin processed pseudogene Ce3 (IGHEP2) in primates. Cytogenet. Cell Genet., 1996, 73: 92-96. |
| PH-1. | Tanabe, H., Ishida, T., Ueda, S., Sofuni, T. and Mizusawa, H. Comparative mapping of the immunoglobulin Ce1 gene (IGHE) in five species of nonhuman primates by fluorescence in situ hybridization. Cytogenetics and Cell Genetics, 1995, 78: 239-242. |