Unit of Human Biology and Genetics, Department of Biological Sciences, School of Science, University of Tokyo

東京大学大学院 理学系研究科 生物科学専攻 / 広域科学大講座:人類進化システム学 /
人類科学大講座:人類生物学・遺伝学研究室

東京大学大学院
            理学系研究科 生物科学専攻
            広域科学大講座:人類進化システム学
            人類科学大講座:人類生物学・遺伝学研究室

1. Hominization - ヒト化

Hominization集団レベルでは、繁殖戦略・雑種形成と生殖隔離・種内変異に興味を持っており、行動観察と分子レベルとの統合を目指します。ゾウ・チンパンジー・テナガザルを対象とした、比較ゲノムの探索を開始しました。下記の病理人類学と関連し、サルの疾病を調べ、モデル化の検討もしています。これまで、細胞レベルを中心とした、加齢、癌化、ゲノム安定性等についても研究してきました。

参考文献

PH-36. Ono, E., Suzuki, J. and Ishida, T. Spectrocolourimetry Visualized Differences in Sexual Skin Colouration in Macaques Folia Primatologica , 2015, 86: 178-186.
PH-35. Matsudaira, K. and Ishida, T. Development of Y-chromosomal Polymorphic Markers in Two Gibbon Species (Hylobates lar and Hylobates pileatus). Jpn. J. Zoo. Wild Anim. Med. , 2015 20(1):15-19.
PH-34. Barelli, C., Matsudaira, K., Wolf, T., Roos, C., Heistermann, M., Hodges, K., Ishida, T., Malaivijitnond, S. and Reichard, U.H. Extra-pair paternity confirmed in wild white-handed gibbons. American Journal of Primatology, 2013, 75: 1185-1195.
PH-33. Matsudaira, K., Reichard, U., Malavijitnond, S. and Ishida, T. Molecular evidence for the introgression between Hylobates lar and H. pileatus in the wild. Primates, 2013, 54: 33-37.
PH-32. Kutsukake, N., Teramoto, M., Homma, S., Mori, Y., Matsudaira, K., Kobayashi, H., Ishida, T., Okanoya, K., and Hasegawa, T. Individual variation in behavioural reactions to unfamiliar conspecific vocalisation and hormonal underpinnings in male chimpanzees. Ethology, 118: 269-280.
PH-31. Ohtani, H., Nakajima, T., Akari, H., Ishida, T. and Kimura, A. Molecular evolution of immunoglobulin superfamily genes in primtes. Immunogenetics, 2011:63: 417-428.
PH-30. Nakayama, K., Shotake, T., Takenaka, O. and Ishida, T. Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macaques. Journal of Mammalian Evolution, 2010, 17: 211-214..
PH-29. Yamamoto, R., Teramoto, M., Hayasaka, I., Ikeda, K., Hasegawa, T. and Ishida, T. Reactivation of lymphocryptovirus (EBVcmp) and the dominance in chimpanzees. Journal of General Virology, 2010, 91: 2049-2053..
PH-28. Matsudaira, K. and Ishida, T. Phylogenetic relationships and divergence dates of the whole mitochondrial genome sequences among three gibbon genera. Molecular Phylogenetics and Evolution, 2010, 55: 454-459.
PH-27. Kutsukake, N., Ikeda, K., Honma, S., Teramoto, M., Mori, Y., Hayasaka, I., Yamamoto, R., Ishida, T., Yoshikawa, Y. and Hasegawa, T. Validation of Salivary Cortisol and Testosterone Assays in Chimpanzees by Liquid Chromatography-Tandem Mass Spectrometry. American Journal of Primatology, 2009, 71: 696-706.
PH-26. Nakajima, T., Ohtani, H., Satta, Y., Uno, Y., Akari, H., Ishida, T. and Kimura, A. Natural selection in the TRL-related genes in the course of primate evolution. Immunogenetics, 2008, 60: 727-735.
PH-25. Nakayama, K., Shotake, T., Takenaka, O. and Ishida, T. Variation of the melanocortin 1 receptor gene in the macaques. American Journal of Primatology, 2008, 70: 778-785.
PH-24. Nakayama, K. and Ishida, T. Alu mediated 100kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes. Genome Research, 2006, 16: 485-490.
PH-23. Kamio, K., Matsushita, I., Hijikata, M., Tanaka, G., Nakata, K., Ishida, T., Tokunaga, K., Kobashi, Y., Taguchi, Y., Homma, S., Nakata, K., Azuma, A., Kudoh, S. and Keicho, N. Promoter analysis and aberrant expression of MUC5B gene in diffuse panbronchiolitis. Am. J. Respir. Crit. Care Med., 2005, 171: 949-957.
PH-22. Tanabe, H., Kupper, K., Ishida, T., Neusser, M. and Mizusawa, H. Inter- and intra-specific gene-density correlated radial chromosome territory arrangements are conserved in Old World monkeys. Cytogenetics and Genome Research, 2005, 108: 255-261.
PH-21. Kutsukake, N. and Castles, D.L. Reconciliation and post-conflict third-party affiliation among wild chimpanzees in the Mahale Mountains, Tanzania. Primates, 2004, 45: 157-165.
PH-20. Nakajima, T., Wooding, S., Sakagami, T., Emi, M., Tokunaga, K., Tamiya, G., Ishigami, T., Umemura, S., Munkhbat, B., Jin, F., Guan-jun, J., Hayasaka, I., Ishida, T., Saito, N., Pavelka, K., Lalouel, J.-M., Jorde, L.B. and Inoue, I. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in worldwide chromosomes. American Journal of Human Genetics, 2004, 74: 898-916.
PH-19. Suto, Y., Ishida, T. and Hirai, M. Multicolor karyotyping of six Old World monkey species. Cytologia, 2003, 68: 431-436.
PH-18. Tachikui, H., Nakajima, T., Saitou, N., Hayasaka, I., Ishida, T. and Inoue, I. Lineage specific homogenization of the polyubiquitin gene among human and great apes. Molecular Biology and Evolution, 2003, 57: 737-744.
PH-17. Suto, Y., Ishikawa, Y., Hyodo, H., Ishida, T., Kasai, F., Tanoue, T., Hayasaka, I., Uchikawa, M., Juji, T. and Hirai, M. Gene arrangement at the Rhesus blood group locus of chimpanzees detected by fiber-FISH. Cytogenetic and Genome Research, 2003, 101: 161-165.
PH-16. Sugawara, H., Harada, N., Ida, T., Ishida, T., Ledbetter, D.H., Yoshiura, K., Ohta, T., Kishino, T., Niikawa, N. and Matsumoto, N. Complex low-copy repeats associated with a common polymorphic inversion at human chromosome 8p23. Genomics, 2003, 82: 238-244.
PH-15. Hohjoh, H., Ohashi, J. and Takasu, M., Nishioka, T., Ishida, T. and Tokunaga, K. Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species. Immunogenetics, 2003, 54: 856-861.
PH-14. Shimizu, Y., Suzuki, J., Terao, K. and Ishida, T. In vitro aging of macaque adherent cells: similar pattern of cellular aging between human and macaque. Mechanisms of Ageing and Development, 2003, 124: 243-250.
PH-13. Shimizu, Y. and Ishida, T. Spontaneous establishment of a novel Japanese macaque cell line. In Vitro Cellular & Developmental Biology-animal, 2002, 38: 311-313.
PH-12. Shimizu, Y. and Ishida, T. Somatic mutations in the p53 gene account for the extension of replicative life-span of macaque cells. Biochem. Biophys. Res. Commun., 2002, 295: 664-650.
PH-11. Dan, I., Watanabe, N.M., Kajikawa, E., Ishida, T., Pandey, A. and Kusumi, A. Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution. Nucleic Acid Research, 2002, 30: 2906-2910.
PH-10. Kimura, M. and Ishida, T. Chimpanzee Band 3 protein polymorphism and the origin of the band 3 Memphis in humans. Folia Primatologica, 2001, 72: 298-300.
PH-9. Kimura, R. and Ishida, T. The human SDF-1 gene polymorphism is located on a mutational hotspot that was identified by the hominoid genome study. Human Biology, 2001, 73: 891-895.
PH-8. Noda, R., Kim, C.G., Takenaka, O., Ferrell, R.E., Tanoue, I., Hayasaka, I., Ueda, S., Ishida, T. and Saitou, N. Mitochondrial 16S rRNA sequence diversity of hominoids. Journal of Heredity, 2001, 92: 490-496.
PH-7. Suzuki, J. and Ishida, T. Age changes in plasma IGF-1 concentration in free-ranging Japanese macaques (Macaca fuscata). Journal of Medical Primatology, 2001, 30: 174-178.
PH-6. 清水裕子 マカクの付着系細胞における in vitro 加齢変化. 霊長類研究 2000, 16: 77-85.
PH-5. Pranomo ZAD, Takeshima, Y., Surono, A., Ishida, T. and Matsuo, M. A novel cryptic exon in intron 2 of the dystrophin gene evolved from intron by creating consensus sequences for splicing in different stages of the anthropoid evolution. Biochem. Biophys. Res. Commun., 2000, 267: 321-328.
PH-4. Bigoni, F., Koehler, U., Stanyon, R., Ishida, T. and Wienberg, J. Fluorescence in situ hybridization establishes homology between human and silvered leaf monkey chromosomes, reveals reciprocal translocations between chromosomes homologous to human Y/5, 1/9, and 6/16, and delineates an X1X2Y1Y2/X1X1X2X2 sex-chromosome system. American Journal of Physical Anthropology, 1997, 102: 315-27.
PH-3. Settheetham, W., Malaivijinond, S. and Ishida, T. Changes in serum immunoglobulin levels among cynomolgus monkeys with long term morphine treatment. Srinakharin Medical Journal, 1996, 11: 57-63.
PH-2. Tanabe, H., Ishida, T., Ueda, S., Sofuni, T. and Mizusawa, H. Molecular anatomy of human chromosome 9: Comparative mapping of the immunoglobulin processed pseudogene Ce3 (IGHEP2) in primates. Cytogenet. Cell Genet., 1996, 73: 92-96.
PH-1. Tanabe, H., Ishida, T., Ueda, S., Sofuni, T. and Mizusawa, H. Comparative mapping of the immunoglobulin Ce1 gene (IGHE) in five species of nonhuman primates by fluorescence in situ hybridization. Cytogenetics and Cell Genetics, 1995, 78: 239-242.

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