Unit of Human Biology and Genetics, Department of Biological Sciences, School of Science, University of Tokyo

東京大学大学院 理学系研究科 生物科学専攻 / 広域科学大講座:人類進化システム学 /
人類科学大講座:人類生物学・遺伝学研究室

東京大学大学院
            理学系研究科 生物科学専攻
            広域科学大講座:人類進化システム学
            人類科学大講座:人類生物学・遺伝学研究室

2. Human Diversity - ヒトの多様性

Human Diversityマラリア抵抗性、体の大きさ、味の好み、その他、に関係する因子等に見られる人類の多様性を集団レベルで調べ、遺伝的あるいは後天的適応の実証を試みています。また、遺伝的多様性を示す形質を指標として、アジアの諸民族の類縁関係・集団の特性を探っています。

参考文献

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HD-34. Nojo, S., Ihara, Y., Furusawa, H., Akamatsu, S. and Ishida, T. Facial resemblance and attractiveness: an experimental study in rural Indonesia. Letters on Evolutionary Behavioral Science, 2011, 2: 9-12.
HD-33. Furusawa, T., Naka, I., Yamauchi, T., Kimura, R., Nakazawa, M., Ishida, T., Nishida, N., Eddie, R., Ohtsuka, R. and Ohashi, J. The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: focus on genetic factors and urbanization. Americal Journal of Human Biology, 2011, 23: 435-444.
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HD-31. Furusawa, T., Naka, I., Yamauchi, T., Natsuhara, K., Kimura, R., Nakazawa, M., Ishida, T., Inaoka, T., Matsumura, Y., Ataka, Y., Nishida, N., Tsuchiya, N., Ohtsuka, r. and Ohashi, J. The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. Human Genetics, 2010, 127: 287-294.
HD-30. Fujimoto, A., Nishida, N., Kimura, R., Miyagawa, T., Yuliwulandari, R., Batubara, L., Mustofa, M.S., Samakkarn, U., Settheetham-Ishida, W., Ishida, T., Morishita, Y., Tsunoda, T., Tokunaga, K. and Ohashi, J. FGFR2, but not EDA, is associated with hair thickness in Asian populations. Journal of Human Genetics, 2009, 54: 461-465.
HD-29. Fujimoto, A., Kimura, R., Ohashil, J., Omi, K, Yuliwulandari, R., Batubara, L., Mustofa, M.S., Samakkarn, U., Settheetham-Ishida, W., Ishida, T., Morishita, Y., Furusawa, T., Nakazawa, M., Otsuka, R. and Tokunaga, K. A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness. Human Molecular Genetics, 2008, 17: 835-843.
HD-28. Ikegaya, H., Zhong, S., Shimizu, H., Sekiyama, M., Soemantri, A., Ishida, T., Nakazawa, M., Ohtsuka, R., Takasaka, T., Shibuya, A., Kitamura, T. and Yogo, Y. The Pacific Lineage (2E) of JC Polyomavirus is Prevalent in Sumba Island, Eastern Indonesia. Anthropological Science, 116: 183-186.
HD-27. Ohashi, J., Naka, I., Kimura, R., Natsuhara, K., Yamauchi, T., Furusawa, T., Nakazawa, M., Ataka, Y., Payarapotikul, J., Nuchnoi, P., Tokunaga, K., Ishida, T., Inaoka, T., Matsumura, Y. and Ohtsuka, R. FTO polymorphisms in Oceanic populations. Journal of Human Genetics, 52: 1031-1035.
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HD-25. Nishizawa, D., Han, W., Hasegawa, J., Ishida, T., Numata, Y., Sato, T., Kawai, A. and Ikeda, K. Association of m-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Neuropsychobiology, 2006, 53: 137-141.
HD-24. Ninokata, A., Kimura, R., Samakkarn, U., Settheetham-Ishida, W. and Ishida, T. Coexistence of five G6PD variants indicates ethnic complexity of Phuket Islanders, southern Thailand. Journal of Human Genetics, 2006, 51: 424-428.
HD-23. Ohashi, J., Naka, I., Kimura, R., Tokunaga, K., Yamauchi, T., Natsuhara, K., Furusawa, T., Yamamoto, R., Nakazawa, M., Ishida, T. and Ohtsuka, R. Polymorphisms in the ABO blood group gene in three populations in the New Georgia group of the Solomon Islands. Journal of Human Genetics, 2006, 51: 407-411.
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HD-20. Soejima, M., Sano, A., Ishida, T., Tachida, H. and Koda, K. Evidence for recent positive selection at the human AIM-1 locus in a European population. Molecular Biology and Evolution, 2006, 23: 179-188.
HD-19. Kimura, R., Nishioka, T., Soemantri, A., Ishida, T. Allele-specific transcript quantification detects haplotypic variation in the levels of the SDF-1 transcripts. Human Molecular Genetics, 2005, 14: 1579-1585.
HD-18. Oota, H., Pakendorf, B., Weiss, G., von Haeseler, A., Settheetham-I., W., Tiwawech, D., Ishida, T., Rischel, J., Stoneking, M. Recent origin and cultural reversion of a hunter-gatherer group. Pros. Biol., 2005, 3: 536-542.
HD-17. Kimura, R., Nishioka, T., Soemantri, A., Ishida, T. Cis-acting effect of the IL1B C-31T polymorphism on IL-1b mRNA expression. Genes and Immunity, 2004, 5: 572-575.
HD-16. Kimura, M., Tamam, M., Soemantri, A., Nakazawa, M., Ataka, Y., Ohtsuka, R., Ishida, T. Distribution of a 27-bp deletion in the band 3 gene in South Pacific islanders. Journal of Human Genetics, 2003, 48: 642-645.
HD-15. Koda, Y., Ishida, T., Tachida, H., Wang, BJ., Pang, H., Soejima, M., Soemantri, A. and Kimura, H. DNA sequence variation of the human ABO-secretor locus (FUT2) in New Guinean populations: possible early human migration from Africa. Human Genetics, 2003, 113: 1013-1016.
HD-14. Kimura, R., Nishioka, T. and Ishida, T. The SDF1-G801A polymorphism is not associated with SDF1 gene expression in Epstein-Barr virus-transformed lymphoblastoid cells. Genes and Immunity, 2003, 4: 356-361.
HD-13. Tajima, A., Sun, C.-S., Pan, I-H., Ishida, T., Saitou, N. and Horai, S. Mitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan: implications for the population history of aboriginal Taiwanese. Human Genetics, 2003, 113: 24-33.
HD-12. Kimura, R., Soemantri, Ag., Settheetham-I., W., Ohtsuka, R., Inaoka, T., Pookajorn, S., Tiwawech, D., Duangchan, P. and Ishida, T. Anthropological implication of the SDF1-3'A allele distribution in Southeast Asia and Melanesia. Journal of Human Genetics, 2002, 47: 117-121.
HD-11. Nakayama, K., Fukamachi, S., Kimura, H., Koda, Y., Soemantri, Ag. and Ishida, T. Distinctive distribution of AIM1 polymorphism among major human populations with different skin color. Journal of Human Genetics, 2002, 47: 92-94.
HD-10. Oota, H., Kurosaki, K., Pookajorn, S., Ishida, T. and Ueda, S. Genetic study of the Paleolithic and Neolithic Southeast Asians. Human Biology, 2001, 73: 225-231.
HD-9. Oota, H., Settheetham-I., W., Tiwawech, D., Ishida, T. and Stoneking, M. Residence patterns influence human MtDNA and Y-chromosome variation. Nature Genetics, 2001, 29: 20-21.
HD-8. Shimizu, Y., Ao, H., Soemantri, Ag., Tiwawech, D., Settheetham-I., W., Kayame, O.W., Nishioka, T. and Ishida, T. Sero- and molecular-typing of Duffy blood group in Southeast Asians and Oceaniams: demonstration of cryptic genotypes by the PCR-RFLP study. Human Biology, 2000, 72: 511-518.
HD-7. Jin, F., Saitou, N., Ishida, T., Sun, C.-S., Pan, I-H., Omoto, K. and Horai, S. Population Genetic studies on nine aboriginal ethnic groups of Taiwan. I. red cell enzyme systems. Anthropological Science, 1999, 107: 229-246.
HD-6. Ishida, T., Suzuki, J., Duangchan, P. and Settheetham-I., W. Preliminary report on the short stature of Southeast Asian forest dwellers, the Manni, in Southern Thailand: lack of an adolescent spurt in plasma IGF-I concentration. Southeast Asian Journal of Tropical Medicine and Public Health, 1998, 29: 62-65.
HD-5. Kimura, M., Shimizu, Y., Settheetham-I., W., Soemantri, Ag., Tiwawech, D., Romphruk, A., Duangchan, P. and Ishida, T. Twenty seven base pair deletion in erythrocyte band 3 protein gene responsible for Southeast Asian ovalocytosis is not common among Southeast Asian. Human Biology, 1998, 70: 993-1000.
HD-4. Shimizu, Y., Kimura, M., Settheetham-I., W., Duangchan, P. and Ishida, T. Serotyping of Duffy blood goup in several Thai ethnic groups. Southeast Asian Journal of Tropical Medicine and Public Health, 1997, 28: 32-35.
HD-3. Shirakawa, T., Nishiyama, K., Lai. P.-S., Ishida, T. and Matsuo, M. Comparison of insertion rate of L1 retroposon into intron 30 of the neurofibromatosis type 1 gene in seven Asian and Pacific populations. Jpn. J. Hum. Genet., 1996, 41: 209-214.
HD-2. Jin, F., Saitou, N., Ishida, T., Sun, C.-H., Pan, I-H., Omoto,K. and Horai, S. Genetic polymorphism of ADA in Taiwan aboriginal populations: new ADA variants detected by isoelectrofocusing method. Anthropological Science, 1995, 103: 227-234.
HD-1. Umetsu, K., Yuasa, I., Harada, A., Suzuki, T., Pan, I-H., Ishida, T., Saitou, N. and Horai, S. Orosomucoid phenotyping with monoclonal antibodies: polymorphic occurrence of ORM1*Q0 in aboriginal Taiwanese populations. Human Heredity, 1995, 45: 181-185.

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