第1462回生物科学セミナー
The Genetics of Epigenetics
Magnus Nordborg（Gregor Mendel Institute, Vienna）
2023年06月09日(金) 16:50-18:35 理学部2号館講堂
DNA methylation is a much-studied but poorly understood epigenetic mark with a clear role in transcriptional silencing, especially of transposable elements. In plants, methylation is frequently stably inherited through meiosis. Work on Arabidopsis thaliana DNA methylation has been shown to reflect origin of sampled plants, which could reflect genetic regulation, or and epigenetic memory. I will discuss what we have learned about these patterns, and their causes.
参考文献
Sasaki E, Kawakatsu T, Ecker JR, and Nordborg M (2019) Common Alleles of CMT2 and NRPE1 Are Major Determinants of CHH Methylation Variation in Arabidopsis Thaliana. PLoS Genetics 15: e1008492.
Sasaki E, Gunis J, Reichardt-Gomez I, Nizhynska V, and Nordborg M (2022) Conditional GWAS of Non-CG Transposon Methylation in Arabidopsis Thaliana Reveals Major Polymorphisms in Five Genes. PLoS Genetics 18: e1010345.
Pisupati R, Nizhynska V, Morales AM, and Nordborg M (2023) On the Causes of Gene-Body Methylation Variation in Arabidopsis Thaliana. PLoS Genetics 19: e1010728.
担当： 東京大学大学院理学系研究科・生物科学専攻・遺伝学研究室
