第1456回生物科学セミナー
神経可塑性のエピジェネティック・転写基盤
北沢 太郎 博士（DANDRITE Nordic-EMBL, オーフス大学, デンマーク）
2023年04月17日(月) 16:00-17:30 理学部2号館201号室
How epigenetic chromatin states regulate neuronal activity-regulated transcription during development is poorly understood. To address this issue, we carried out epigenetic and transcriptional profiling of neuronal activity-response genes during mouse somatosensory neuron development. We found that in developing sensory neurons, prior to sensory activity-dependent induction, immediate early genes (IEGs, e.g. Fos) are embedded into a unique ‘bipartite' Polycomb chromatin signature. Namely, IEGs carry active H3K27ac mark on promoters and enhancers, but repressive Polycomb-H3K27me3 mark on gene bodies. This is a novel epigenetic chromatin mechanism regulating the rapidity and amplitude of the transcriptional response to relevant stimuli, while preventing inappropriate activation of IEGs at pre-sensory stages.
In addition, I want to introduce my new laboratory that has opened in the DANDRITE-Nordic-EMBL in Denmark. I will investigate epigenetic and transcriptional basis of memory engram plasticity, be taking advantage of the beyond state-of-the-art genomics technologies.
参考文献
Kitazawa, T., et al., Nature Genetics. 2021 Mar;53(3):379-391.
A unique bipartite Polycomb signature regulates stimulus-response transcription during development.
Kitazawa, T., et al., Curr Opin Neurobiol. 2018 Oct 17;53:210-219.
Barrelette map formation in the prenatal mouse brainstem.
Our lab HP: https://www.kitazawa-lab.com/
担当： 東京大学大学院理学系研究科・生物科学専攻・脳機能学研究室
