濡木研公開ラボセミナー
Mechanisms underlying AMPA receptor organisation and synaptic localisation
Ingo Greger（Research Leader, Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK）
2023年01月17日(火) 16:00-17:30 理学部1号館中央棟341号室
AMPA glutamate receptors (AMPARs) mediate fast excitatory neurotransmission throughout the brain, and are central players in various forms of synaptic plasticity that underlies learning. In addition to four core subunits (GluA1-4), an array of auxiliary subunits render AMPAR response properties uniquely versatile, tuned to the needs of a given circuitry. These assemble with the receptor core in various stoichiometries, and in a brain-region specific fashion.
Recent cryo-EM structures, combined with functional studies, have started to shed light on the arrangement of both, core and auxiliary subunits. Hence, despite tremendous versatility, unique to AMPA-type receptors, organizing principles are beginning to emerge. This information will ultimately allow us to decipher the activation mechanisms underlying synaptic AMPAR responses. In this talk I will discuss our current understanding of AMPAR organization, the differential action of core subunits (GluA1 versus GluA2), and recent insights into its modulation by prominent auxiliary subunits at the level of the receptor and at the synapse.
担当：東京大学大学院理学系研究科・生物科学専攻・濡木理
