第1313回生物科学セミナー
Temperature homeostasis: Circadian rhythms and Hunger
Fumika Hamada（Associate Professor, Cincinnati Children’s Hospital Medical Center, USA）
2019年11月27日(水) 10:30-12:00 理学部3号館 326号室
How do animals change their behavior based on past and current experiences, and through the integrations of different sensory modes? We are particularly interested in how the circadian clock and feeding experience modulates temperature homeostasis. The circadian clock regulates body temperature rhythm; human body temperature increases during wakefulness and decreases during sleep. Body temperature rhythm is fundamental for maintaining homeostasis, but the mechanisms that regulate body temperature rhythm are largely unknown. We are also interested in elucidating how feeding experiences modulate temperature homeostasis. For example, hunger strongly modulates animal behavior and physiology, which causes a decrease in body temperature in mammals. Once feeding starts, starved animals quickly increase their body temperature prior to consuming food. This anticipatory response is important for animals to prepare to respond to, digest, and then absorb metabolite nutrients. However, critical questions remain as to how the starved state is represented in the brain and as to how the initiation of feeding quickly overwrites the existing program. In this talk, I would like to discuss our recent findings, in which the evolutionarily conserved molecular mechanisms control body temperature rhythm as well as feeding state-dependent thermoregulation in both mammals and flies.
References
1. Goda, T., Doi, M., Umezaki, Y., Murai, I., Shimatani, H., Chu, M.L., Nguyen, V.H., Okamura.H., and Hamada F.N. Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals Genes and Development, 2018 Jan 15;32(2):140-155
2. Kaneko H., Head L.M., Ling J., Liu Y., Hardin. P.E., Emery.P., & Hamada F.N. Circadian rhythm of temperature preference and its neural control in Drosophila. Current Biology, 2012 Oct 9;22(19):1851-7
3. Umezaki, Y., Hayley, S.E., Chu, M, L., Seo, H, W., Shah, P., and Hamada F.N Feeding-state-dependent modulation of temperature preference requires insulin signaling in Drosophila warm-sensing neurons. Current Biology, 2018 March 5;28(5):779-787
