第1219回生物科学セミナー

Nuclear reorganizations controlling sleep and metabolism

Steven A. Brown(University of Zürich, Switzerland)

2018年05月31日(Thu)    16:30-18:00  理学部3号館 326号室   

In cortex, an extensive transcriptional program driven by circadian and sleep-wake-dependent neuronal activity is important to reprogram synaptic function and cellular metabolism across day and night. We find that novel membrane-less nuclear structures containing members of the DBHS (Drosophila Behavior, Human Splicing) protein family are essential to achieve this transcriptional program at a cellular level, and in turn to potentiate sleep slow waves at a network level. These “neurospeckles” are driven by circadian and sleep-wake-dependent neuronal firing in a pathway employing mainly mGluR5 and Protein Kinase C, and are important for sleep gene expression and the homeostatic response to sleep deprivation. Surprisingly, in liver very similar speckles are driven by feeding cycles, and serve to optimize metabolic transcriptional programs. Thus, our results identify DBHS protein clusters as dynamic, intra-nuclear structures important for regulation of diverse tissue-specific transcriptional programs.