
メンバー
教員
教授 大橋 順 (Jun OHASHI)

略歴
2021年04月 東京大学大学院理学系研究科生物科学専攻教授
2014年10月 東京大学大学院理学系研究科生物科学専攻准教授
2011年10月 筑波大学医学医療系准教授(組織改編による名称変更)
2008年07月 筑波大学大学院人間総合科学研究科社会環境医学専攻准教授
2007年04月 東京大学大学院医学系研究科人類遺伝学分野助教
2003年05月 米国コーネル大学分子生物学遺伝学研究分野文部科学省在外研究員
1999年09月 博士(保健学)学位取得 東京大学
1997年10月 東京大学大学院医学系研究科人類遺伝学分野助手
1997年10月 東京大学大学院医学系研究科国際保健学専攻研究生
1997年09月 東京大学大学院医学系研究科国際保健学専攻博士課程単位取得済退学
1995年03月 東京大学大学院医学系研究科国際保健学専攻修士課程修了
1993年03月 東京大学医学部保健学科卒業
大橋順 研究業績
Publication list (as of Jul 4, 2022)
Original article (English)
2022
216) Nii-Trebi NI, Matsuoka S, Kawana-Tachikawa A, Bonney EY, Abana CZ, Ofori SB, Mizutani T, Ishizaka A, Shiino T, Ohashi J, Naruse TK, Kimura A, Kiyono H, Ishikawa K, Ampofo WK, Matano T (2022) Super high-resolution single-molecule sequence-based typing of HLA class I alleles in HIV-1 infected individuals in Ghana. PLoS ONE 17: e0269390.
215) Nishida N, Sugiyama M, Kawai Y, Naka I, Iwamoto N, Suzuki T, Suzuki M, Miyazato Y, Suzuki S, Izumi S, Hojo M, Tsuchiura T, Ishikawa M, Ohashi J, Ohmagari N, Tokunaga K, Mizokami M (2022) Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19. Scientific Reports 12: 3854.
214) Koga M, Senkoji T, Kubota M, Ishizaka A, Mizutani T, Sedohara A, Ikeuchi K, Kikuchi T, Adachi E, Saito M, Koibuchi T, Hosomichi K, Ohashi J, Kawana-Tachikawa A, Matano T, Tsutsumi T, Yotsuyanagi H (2022) Predictors associated with a better response to the Japanese aluminum-free hepatitis A vaccine, Aimmugen®, for people living with HIV. Hepatology Ressearch 52: 227-234.
213) Kawamura R, Miyao S, Onuma H, Uchigata Y, Kawasaki E, Ohashi J, Shiraishi S, Nishida W, Yokomoto-Umakoshi M, Takata Y, Osawa H, Makino H (2022) Recurrent hypoglycemia due to a high titer of insulin antibody in response to exogenous insulin administration in two cases of type 1 diabetes. Internal Medicine 61: 687-695.
2021
212) Maharani N, Soetadji A, Utari A, Naka I, Ohashi J, Mexitalia M (2021) Cytochrome b-245 alpha chain gene variants and arterial function in Indonesian short stature children. Cardiology Research 12: 351-357.
211) Isshiki M, Naka I, Kimura R, Nishida N, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R, Ohashi J (2021) Admixture with indigenous people helps local adaptation: admixture-enabled selection in Polynesians. BMC Ecology and Evolution 21: 179.
210) Isshiki M, Watanabe Y, Ohashi J (2021) Geographic variation in the polygenic score of height in Japan. Human Genetics 140: 1097–1108.
209) Anzurez A, Naka I, Miki S, Hosoya-Nakayama K, Isshiki M, Watanabe
Y, Nakamura-Hoshi M, Seki S, Matsumura T, Takano T, Onodera T, Adachi Y,
Moriyama S, Terahara K, Tachikawa N, Yoshimura Y, Sasaki H, Horiuchi H,
Miyata N, Miyazaki K, Koga M, Ikeuchi K, Nagai H, Saito M, Adachi E, Yotsuyanagi
H, Kutsuna S, Kawashima A, Miyazato Y, Kinoshita N, Kouno C, Tanaka K,
Takahashi Y, Suzuki T, Matano T, Ohashi J, Kawana-Tachikawa A (2021) Association
of Human Leukocyte Antigen DRB1*09:01 with severe COVID-19. HLA 98: 37-42.
208) Nishida N, Sugiyama M, Ohashi J, Kawai Y, Khor SS, Nishina S, Yamasaki
K, Yazaki H, Okudera K, Tamori A, Eguchi Y, Sakai A, Kakisaka K, Sawai
H, Tsuchiura T, Ishikawa M, Hino K, Sumazaki R, Takikawa Y, Kanda T, Yokosuka
O, Yatsuhashi H, Tokunaga K, Mizokami M (2021) Importance of HBsAg recognition
by HLA molecules as revealed by responsiveness to different hepatitis B
vaccines. Scientific Reports 11: 3703.
207) Mizuno F, Naka I, Ueda S, Ohashi J, Kurosaki K (2021) The number of SNPs
required for distinguishing Japanese from other East Asians. Legal Medicine 49:101849.
2020
206) Watanabe Y, Isshiki M, Ohashi J (2020) Prefecture-level population
structure of the Japanese based on SNP genotypes of 11,069 individuals.
Journal of Human Genetics 66: 431-437.
205) Arayasongsak U, Naka I, Ohashi J, Patarapotikul J, Nuchnoi P, Kalambaheti
T, Sa-Ngasang A, Chanama S, Chaorattanakawee S (2020) Genetic association
study of interferon lambda 3, CD27, and human leukocyte antigen-DPB1 with
dengue severity in Thailand. BMC Infectious Diseases 20: 948.
204) Miotto O, Sekihara M, Tachibana S, Yamauchi M, Pearson RD, Amato R,
Gonçalves S, Mehra S, Noviyanti R, Marfurt J, Auburn S, Price RN, Mueller
I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel M, Laman M, Barry A, Ringwald
P, Ohashi J, Hombhanje F, Kwiatkowski DP, Mita T (2020) Emergence of artemisinin-resistance
Plasmodium falciparum with kelch13 C580Y mutations on the island of New
Guinea. PLoS Pathogens 16: e1009133.
203) Toyoda M, Kamori D, Tan TS, Goebuchi K, Ohashi J, Carlson J, Kawana-Tachikawa
A, Gatanaga H, Oka S, Pizzato M, Ueno T (2020) Impaired ability of Nef
to counteract SERINC5 is associated with reduced plasma viremia in HIV-infected
individuals. Scientific Reports 10: 19416.
202) Okamura K, Abe Y, Naka I, Ohashi J, Yagami A, Matsunaga K, Kobayashi
Y, Fukai K, Tanemura A, Katayama I, Masui Y, Ito A, Yamashita T, Nagai
H, Nishigori C, Oiso N, Aoyama Y, Araki Y, Saito T, Hayashi M, Hozumi Y,
Suzuki T (2020) Genome-wide association study identifies CDH13 as a susceptibility
gene for rhododendrol-induced leukoderma. Pigment Cell and Melanoma Research
33: 826-833.
201) Liu X, Kosugi S, Koide R, Kawamura Y, Ito J, Miura H, Matoba N, Matsuzaki
M, Fujita M, Kamada AJ, Nakagawa H, Tamiya G, Matsuda K, Murakami Y, Kubo
M, Aswad A, Sato K, Momozawa Y, Ohashi J, Terao C, Yoshikawa T, Parrish
NF, Kamatani Y (2020) Endogenization and excision of human herpesvirus
6 in human genomes. PLoS Genetics 16: e1008915.
200) Yamamoto T, Hashimoto M, Nagatomi K, Nogami T, Sofue Y, Hayashi T,
Ido Y, Yatsushiro S, Abe K, Kajimoto K, Tamari N, Awuor B, Sonye G, Kongere
J, Munga S, Ohashi J, Oka H, Minakawa N, Kataoka M, Mita T (2020) Development
of a quantitative, portable, and automated fluorescent blue-ray device-based
malaria diagnostic equipment with an on-disc SiO2 nanofiber filter. Scientific
Reports 10: 6585.
199) Kim J, Jeon S, Choi JP, Blazyte A, Jeon Y, Kim JI, Ohashi J, Tokunaga
K, Sugano S, Fucharoen S, Al-Mulla F, Bhak J (2020) The origin and composition
of Korean ethnicity analyzed by ancient and present-day genome sequences.
Genome Biol Evol 12: 553-565.
198) Isshiki M, Naka I, Watanabe Y, Nishida N, Kimura R, Furusawa T, Natsuhara
K, Yamauchi T, Nakazawa M, Ishida T, Eddie R, Ohtsuka R, Ohashi J (2020)
Admixture and natural selection shaped genomes of an Austronesian-speaking
population in the Solomon Islands. Scientific Reports 10: 6872.
197) Arayasongsak U, Naka I, Ohashi J, Patarapotikul J, Nuchnoi P, Kalambaheti
T, Sa-Ngasang A, Chanama S (2020) Interferon lambda 1 is associated with
dengue severity in Thailand. International Journal of Infectious Diseases
93: 121-125.
2019
196) Hang NTL, Hijikata M, Maeda S, Thuong PH, Ohashi J, Huan HV, Hoang
NP, Miyabayashi A, Cuong VC, Seto S, Hung NV, Keicho N (2019) Whole genome
sequencing, analyses of drug resistance-conferring mutations, and correlation
with transmission of Mycobacterium tuberculosis carrying katG-S315T in
Hanoi, Vietnam. Scientific Reports 9: 15354.
195) Watanabe Y, Naka I, Khor SS, Sawai H, Hitomi Y, Tokunaga K, Ohashi J, Analysis of whole Y-chromosome sequences reveals the Japanese population
history in the Jomon period. Scientific Reports 9: 8556.
194) Onuma H, Kawamura R, Tabara Y, Yamashita M, Ohashi J, Kawasaki E,
Imagawa A, Yamada Y, Chujo D, Takahashi K, Suehiro T, Takata Y, Osawa H,
Makino H. Variants in the BACH2 and CLEC16A gene may be associated with
susceptibility to insulin-triggered type 1 diabetes. Journal of Diabetes
Investigation 10: 1447–1453.
193) Wah ST, Hananantachai H, Patarapotikul J, Naka I, Ohashi J, Nuchnoi
P. microRNA-27a and microRNA-146a SNP in cerebral malaria. Molecular Genetics
and Genomic Medicine 7: e00529.
2018
192) Isshiki M, Naka I, Nishida N, Furusawa T, Kimura R, Natsuhara K, Yamauchi
T, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R, Ohashi J (2018)
Association of an intronic SNP of the EFEMP1 gene with height in Tongans.
Meta Gene 17: 172-176.
191) Ohashi J, Naka I, Furusawa T, Kimura R, Natsuhara K, Yamauchi T, Nakazawa
M, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R. Association study of CREBRF
missense variant (rs373863828:G>A; p.Arg457Gln) with levels of serum
lipid profile in the Pacific populations. Annals of Human Biology 45: 215-219.
190) Mita T, Hombhanje F, Takahashi N, Makoto S, Yamauchi M, Tsukahara
T, Kaneko A, Endo H, Ohashi J. Rapid selection of sulphadoxine-resistant
Plasmodium falciparum and its effect on within-population genetic diversity
in Papua New Guinea. Scientific Reports 8: 5565.
189) Nishida N, Sugiyama M, Sawai H, Nishina S, Sakai A, Ohashi J, Khor
SS, Kakisaka K, Tsuchiura T, Hino K, Sumazaki R, Takikawa Y, Murata K,
Kanda T, Yokosuka O, Tokunaga K, Mizokami M (2018) Key HLA-DRB1-DQB1 haplotypes
and role of the BTNL2 gene for response to a hepatitis B vaccine. Hepatology
68: 848–858.
188) Ikeda M, Kaneko M, Tachibana S, Balikagala B, Sakurai-Yatsushiro M,
Yatsushiro S, Takahashi N, Yamauchi M, Sekihara M, Hashimoto M, Katuro
OT, Olia A, Obwoya PS, Auma MA, Anywar DA, Odongo-Aginya EI, Okello-Onen
J, Hirai M, Ohashi J, Palacpac NMQ, Kataoka M, Tsuboi T, Kimura E, Horii
T, Mita T. Detection of Plasmodium falciparum isolates with high survival
rates in ex-vivo ring-stage survival assay (RSA) in Uganda. Emerging Infectious
Diseases 24: 718-726.
187) Chaorattanakawee S, Nuchnoi P, Hananantachai H, Tumkosit U, Saunders
D, Naka I, Ohashi J, Patarapotikul J (2018) Sequence variation in Plasmodium
falciparum merozoite surface protein-2 is associated with virulence causing
severe and cerebral malaria. PLoS ONE 13: e0190418.
186) Issiki M, Naka I, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa
M, Ishida T, Ohtsuka R, Ohashi J (2018) Mitochondrial DNA variations in
Austronesian-speaking populations living in the New Georgia Islands, the
Western Province of the Solomon Islands. Journal of Human Genetics 63:
101-104.
2017
185) Eriguchi Y, Kuwabara H, Inai A, Kawakubo Y, Nishimura F, Kakiuchi
C, Tochigi M, Ohashi J, Aoki N, Kato K, Ishiura H, Mitsui J, Tsuji S, Doi
K, Yoshimura J, Morishita S, Shimada T, Furukawa M, Umekage T, Sasaki T,
Kasai K, Kano Y (2017) Identification of candidate genes involved in the
etiology of sporadic Tourette Syndrome by exome sequencing. Neuropsychiatric
Genetics 174: 712-723.
184) Nakayama K, Ohashi J, Watanabe K, Munkhtulga L, Iwamoto S (2017) Evidence
for very recent positive selection in Mongolians. Molecular Biology and
Evolution 34: 1936-1946.
183) Naka I, Furusawa T, Kimura R, Natsuhara K, Yamauchi T, Nakazawa M,
Ataka Y, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R, Ohashi J (2017) A
missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass
index in Oceanic populations. Journal of Human Genetics 62: 847-849.
182) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa
M, Ishida T, Ohtsuka R, Ohashi J (2017) Polymorphisms Associated with a
Tropical Climate and Root Crop Diet Induce Susceptibility to Metabolic
and Cardiovascular Diseases in Solomon Islands. PLoS ONE 12: e0172676.
181) Yasukochi Y, Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2017)
Evolution of Fseg/Cseg dimorphism in region III of Plasmodium falciparum
eba-175 gene. Infection, Genetics and Evolution 49: 251–255.
180) Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi
M, Nishimiya T, Ohyagi Y, Kawamoto R, Kohara K, Miki T, Osawa H (2017)
Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on
Plasma Resistin: Genotype and DNA Methylation. The Journal of Clinical
Endocrinology & Metabolism 102: 884-892.
179) Yasukochi Y, Ohashi J (2017) Elucidating the origin of HLA-B*73 allelic
lineage: Did modern humans benefit by archaic introgression? Immunogenetics
69: 63-67.
178) Kamori D, Hasan Z, Ohashi J, Kawana-Tachikawa A, Gatanaga H, Oka S,
Ueno T (2017) Identification of two unique naturally occurring Vpr sequence
polymorphisms associated with clinical parameters in HIV-1 chronic infection.
Journal of Medical Virology 89: 123-129.
2016
177) Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata
Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y,
Miki T, Kohara K, Osawa H (2016) A genome-wide association study of plasma
resistin levels identified rs1423096 and rs10401670 as possible functional
variants in the Japanese population. Physiological Genomics 48: 874–881.
176) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Wichukchinda N, Sawanpanyalert
P, Patarapotikul P, Tsuchiya N, Ohashi J (2016) Association of BAK1 single
nucleotide polymorphism with a risk for dengue hemorrhagic fever. BMC Medical
Genetics 17: 43.
175) Ohashi J, Naka I, Hananantachai H, Patarapotikul J (2016) Association
of PECAM1/CD31 polymorphisms with cerebral malaria. International Journal
of Molecular Epidemiology and Genetics 7: 87-94.
174) Nishida N, Ohashi J, Khor SS, Sugiyama M, Tsuchiura T, Sawai H, Hino
K, Honda M, Kaneko S, Yatsuhashi H, Yokosuka O, Koike K, Kurosaki M, Izumi
N, Korenaga M, Kang JH, Tanaka E, Taketomi A, Eguchi Y, Sakamoto N, Yamamoto
K, Tamori A, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y,
Ide T, Hiasa Y, Kojima H, Yamamoto K, Nakamura M, Saji H, Sasazuki T, Kanto
T, Tokunaga K, Mizokami M (2016) Understanding of HLA-conferred susceptibility
to chronic hepatitis B infection requires HLA genotyping-based association
analysis. Scientific Reports 6: 24767.
173) Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja C,
Win Z, Htike W, Marma A, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale W,
Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira M, Endo H, Ohashi
J (2016) Little polymorphism at the K13 propeller locus in worldwide Plasmodium
falciparum populations prior to the introduction of artemisinin combination
therapies. Antimicrobial Agents and Chemotherapy 60: 3340-3347.
172) Liu X, Homma A, Sayadi J, Yang S, Ohashi J, Takumi T (2016) Sequence
features associated with the cleavage efficiency of CRISPR/Cas9 system.
Scientific Reports 6: 19675.
171) Hamada J, Onuma H, Ochi F, Hirai H, Takemoto K, Miyoshi A, Matsushita
M, Kadota Y, Ohashi J, Kawamura R, Takata Y, Nishida W, Hashida S, Ishii
E, Osawa H (2016) Endoplasmic reticulum stress induced by tunicamycin increases
resistin mRNA through the PERK-ATF4-CHOP pathway in THP-1 human monocytes.
Journal of Diabetes Investigation 7: 312–323.
2015
170) Nishida N, Ohashi J, Sugiyama M, Tsuchiura T, Yamamoto K, Hino K,
Honda M, Kaneko S, Yatsuhashi H, Koike K, Yokosuka O, Tanaka E, Taketomi
A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, Mizokami
M (2015) Effects of HLA-DPB1 genotypes on chronic hepatitis B infection
in Japanese. Tissue Antigens 86: 406-412.
169) Yasukochi Y, Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2015)
Genetic evidence for contribution of human dispersal to the genetic diversity
of EBA-175 in Plasmodium falciparum. Malaria Journal 14: 293.
168) Miyadera H, Ohashi J, Lernmark A, Kitamura T, Tokunaga K (2015) Cell-surface
MHC density profiling reveals instability of autoimmunity-associated HLA.
The Journal of Clinical Investigation 125: 275-291.
2014
167) Nishida W, Nagata M, Imagawa A, Hanafusa T, Ohashi J, Takahashi K,
Suehiro T, Yamada Y, Chujo D, Kawasaki E, Kawamura R, Onuma H, Osawa H,
Makino H (2014) Insulin administration may trigger type 1 diabetes in Japanese
type 2 diabetes patients with type 1 diabetes high-risk HLA class II and
the insulin gene VNTR genotype. The Journal of Clinical Endocrinology &
Metabolism 99: E1793-E1797.
166) Fujita A, Ishibe N, Yoshihara T, Ohashi J, Makino H, Ikeda M, Setoguchi
H (2014) Rapid reversal of neuromuscular blockade by sugammadex after continuous
infusion of rocuronium in patients with liver dysfunction undergoing hepatic
surgery. Acta Anaesthesiologica Taiwanica 52: 54-58.
165) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Chanama S, Wichukchinda
N, Sawanpanyalert P, Patarapotikul P, Tsuchiya N, Ohashi J (2014) A replication
study confirms the association of GWAS-identified SNPs at MICB and PLCE1
in Thai patients with dengue shock syndrome. BMC Medical Genetics 15: 58.
164) Naka I, Patarapotikul J, Hananantachai H, Imai H, Ohashi J (2014)
Association of the endothelial protein C receptor (PROCR) rs867186-G allele
with protection from severe malaria. Malaria Journal 13: 105.
163) Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2014) Lack of
association between BSG polymorphisms and cerebral malaria. Japanese Journal
of Infectious Diseases 67: 432-435.
162) Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac NMQ, Hisaeda
H, Matsuoka H, Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T,
Furusawa M, Tanabe K (2014) Generation of rodent malaria parasites with
a high mutation rate by destructing proofreading activity of DNA polymerase
σ. DNA Research 21: 439-446.
161) Ohashi J, Suzuki Y, Naka I, Hananantachai H, Patarapotikul J (2014)
Diversifying selection on the thrombospondin-related adhesive protein (TRAP)
gene of Plasmodium falciparum in Thailand. PLoS ONE 9: e90522.
160) Sa-Ngasang A, Ohashi J, Naka I, Anantapreecha S, Sawanpanyalert P,
Patarapotikul J. Association of IL1B -31C/T and IL1RA variable number of
an 86-bp tandem repeat with Dengue Shock Syndrome in Thailand (2014) The
Journal of Infectious Diseases 210: 138-145.
159) Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen
MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki
M, Asahina Y, Izumi N, Kang JH, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki
Y, Itoh Y, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki
K, Hino K, Tanaka E, Mochida S, Watanabe M, Eguchi Y, Masaki N, Murata
K, Korenaga M, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami
M (2014) New susceptibility and resistance HLA-DP alleles to HBV-related
diseases identified by a trans-ethnic association study in Asia. PLoS ONE
9: e86449.
158) Shiraishi S, Miyao S, Kikuchi N, Ochi K, Sato E, Ohashi J, Kawamura
R, Osawa H, Makino H (2014) Effects of carbohydrate counting on glycemic
control and quality of life in patients with type 1 diabetes: a pilot study.
Diabetology International 5: 181-186.
157) Mita T, Ohashi J, Nakamura M, Endo H, Tanabe K (2014) Ordered accumulation
of mutations conferring resistance to sulfadoxine-pyrimethamine in the
Plasmodium falciparum parasite. The Journal of Infectious Diseases 209:
130-139.
2013
156) Naka I, Ohashi J, Kimura R, Inaoka T, Matsumura Y (2013) Association
of ADRB2 polymorphism with triglyceride levels in Tongans. Lipids in Health
and Disease 12: 110.
155) Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa
T, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, InaokaT, Iwamoto
S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J (2013) A functional SNP
upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with
obesity in Oceanic populations. International Journal of Obesity 37: 1204-1210.
154) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa
M, Ishida T, Inaoka T, Matsumura Y, Ataka Y, Ohtsuka R, Ohashi J (2013)
Hypertension Susceptibility Gene Prevalence in the Pacific Islands and
Associations with Hypertension in Melanesia. Journal of Human Genetics
58: 142-149.
153) Noguchi S, Hijikata M, Hamano E, Matsushita I, Ito H, Ohashi J, Nagase
T, Keicho N (2013) MxA transcripts with distinct first exons and modulation
of gene expression levels by single-nucleotide polymorphisms in human bronchial
epithelial cells. Immunogenetics 65: 107-114.
152) Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi
M, Nishimiya T, Kawamoto R, Kohara K, Miki T, Osawa H (2013) Plasma resistin
is associated with single nucleotide polymorphisms of a possible resistin
receptor, the decorin gene, in the general Japanese population. Diabetes
62: 649-652.
2012
151) Japanese Archipelago Human Population Genetics Consortium (Consortium
members: Jinam T, Nishida N, Hirai M, Kawamura S, Oota H, Umetsu K, Kimura
R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T,
Naritomi K, Yanagi K, Niikawa N, Omoto K, Tokunaga K, Saitou N (2012) The
history of human populations in the Japanese Archipelago inferred from
genome-wide SNP data with a special reference to the Ainu and the Ryukyuan
populations. Journal of Human Genetics 57: 787-795.
150) Kawashima M, Ohashi J, Nishida N, Tokunaga K (2012) Evolutionary analysis
of classical HLA class I and II genes suggests that recent positive selection
acted on DPB1*04:01 in Japanese population. PLoS ONE 7: e46806.
149) Onuma H, Tohyama M, Imagawa A, Hanafusa T, Kobayashi T, Kano Y, Ohashi
J, Hashimoto K, Osawa H, Makino H (2012) High frequency of HLA B62 in fulminant
type 1 diabetes with the drug-induced hypersensitivity syndrome. The Journal
of Clinical Endocrinology & Metabolism 97: E2277-E2281.
148) Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, Ikenaka
T, Nakayama H, Hashimoto A, Takaoka H, Arinuma Y, Okazaki Y, Futami H,
Komiya A, Fukui N, Nakamura T, Migita K, Suda A, Nagaoka S, Tsuchiya N,
Tohma S (2012) Association of Human Leukocyte Antigen with Interstitial
Lung Disease in Rheumatoid Arthritis: A Protective Role for Shared Epitope.
PLoS One 7: e33133.
147) Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa
A, Takanashi M, Satake M, Nakajima K, Parham P, Arase H, Tokunaga K, Patarapotikul
J, Yabe T (2012) Significant association of KIR2DL3-HLA-C1 combination
with cerebral malaria and implications for co-evolution of KIR and HLA.
PLoS Pathogens 8: e1002565.
146) Naka I, Ohashi J, Kimura R, Furusawa T, Yamauchi T, Nakazawa M, Natsuhara
K, Ataka Y, Nishida N, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R (2012)
DRD4 VNTR polymorphism in Oceanic populations. Anthropological Science
120: 151-155.
145) Hijikata M, Shojima J, Matsushita I, Tokunaga K, Ohashi J, Hang NTL,
Horie T, Sakurada S, Hoang NP, Thuong PH, Lien LT, Keicho N (2012) Association
of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese.
Human Genetics 131: 675-682.
2011
144) Kawamura R, Tabara Y, Onuma H, Kawamoto R, Ohashi J, Takata Y, Nishida
W, Katsuhiko Kohara K, Makino H, Miki T, Osawa H (2011) A single-nucleotide
polymorphism in the human THADA gene is associated with circulating resistin
in the general Japanese population. Diabetology International 2: 190-196.
143) Kraisin S, Naka I, Patarapotikul J, Nantakomol D, Nuchnoi P, Hananantachai
H, Tsuchiya N, Ohashi J (2011) Association of ADAMTS13 polymorphism with
cerebral malaria. Malaria Journal 10: 366.
142) Mita T, Venkatesan M, Ohashi J, Culleton R, Takahashi N, Tsukahara
T, Ndounga M, Dysoley L, Endo H, Hombhanje F, Ferreira MU, Plowe CV, Tanabe
K (2011) Limited geographical origin and global spread of sulfadoxine-resistant
dhps alleles in Plasmodium falciparum populations. The Journal of Infectious
Diseases 204: 1980-1988.
141) Naka I, Nishida N, Ohashi J (2011) No evidence for strong recent positive
selection favoring the 7 repeat allele of VNTR in the DRD4 gene. PLoS One
6: e24410.
140) Koga M, Kawasaki A, Ito I, Furuya T, Ohashi J, Kyogoku C, Ito S, Hayashi
T, Matsumoto I, Kusaoi M, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
(2011) Cumulative Association of Eight Susceptibility Genes with Systemic
Lupus Erythematosus in a Japanese Female Population. Journal of Human Genetics
56: 503-507.
139) Myles S, Lea RA, Ohashi J, Chambers GK, Weiss JG, Hardouin E, Engelken
J, Macartney-Coxson DP, Eccles DA, Naka I, Kimura R, Inaoka T, Matsumura
Y, Stoneking M (2011) Testing the thrifty gene hypothesis: the Gly482Ser
variant in PPARGC1A is associated with BMI in Tongans. BMC Medical Genetics
12: 10.
138) Hijikata M, Matsushita I, Tanaka G, Tsuchiya T, Ito H, Tokunaga K,
Ohashi J, Homma S, Kobashi Y, Taguchi Y, Azuma A, Kudoh S, Keicho N (2011)
Molecular cloning of two novel mucin-like genes in the disease-susceptibility
locus for diffuse panbronchiolitis. Human Genetics 129: 117-128.
137) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M,
Ishida T, Nishida N, Eddie R, Ohtsuka R, Ohashi J (2011) The serum leptin
level and body mass index in Melanesian and Micronesian Solomon Islanders:
Focus on genetic factors and urbanization. American Journal of Human Biology
23: 435-444.
136) Ohashi J, Naka I, Tsuchiya N (2011) The impact of natural selection
on an ABCC11 SNP determining earwax type. Molecular Biology and Evolution
28: 849-857.
2010
135) Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi
M, Ohashi J, Graham RR, Matsuta K, Behrens TW, Tohma S, Takasaki Y, Hashimoto
H, Sumida Tand, Tsuchiya N (2010) Association of TNIP1 with systemic lupus
erythematosus in a Japanese population: a case-control association study.
Arthritis Research & Therapy 12: R174.
134) Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida
W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H (2010) The GCKR rs780094
polymorphism is associated with susceptibility of type 2 diabetes, reduced
fasting plasma glucose levels, increased triglycerides levels, and lower
HOMA-IR in Japanese population. Journal of Human Genetics 55: 600-604.
133) Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita
I, Ohashi J, Yamada N, Moolphate S, Summanapan S, Chuchottaworn C, Manosuthi
W, Kantipong P, Kanitvittaya S, Sawanpanyalert P, Keicho N, Khusmith S,
Tokunaga K. (2010) Association analysis of susceptibility candidate region
on chromosome 5q31 for tuberculosis. Genes and Immunity 11: 416-422.
132) Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata
Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H (2010)
A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer
the Highest Plasma Resistin in the General Japanese Population. PLoS One
5(3): e9718.
131) Osawa H, Tabara Y, Ohashi J, Kawamura R, Onuma H, Makino H (2010)
Is rs34861192 or rs1862513 a more promising variant for determining plasma
resistin in an aged Japanese population? Diabetologia 53: 795-797.
130) Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, Ohashi J, Kawamoto M,
Fujimoto M, Takehara K, Sato S, Hara M, Tsuchiya N (2010) Association of
FAM167A (C8orf13) - BLK region with systemic sclerosis. Arthritis &
Rheumatism 62: 890-895.
129) Nantakomol D, Chanprasert S, Soogarun S, Ohashi J, Nuchnoi P (2010)
Affordable technology for enumeration of the absolute CD4 T-lymphocyte
count by cell bead assay. LabMedicine 41: 423-428.
128) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M,
Ishida T, Inaoka T, Matsumura Y, Ataka Y, Nishida N, Tsuchiya N, Ohtsuka
R, Ohashi J (2010) The Q223R polymorphism in LEPR is associated with obesity
in Pacific Islanders. Human Genetics 127: 287-294.
127) Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa
M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki
N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani
S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T (2010) Brain
Cannabinoid CB2 Receptor in Schizophrenia. Biological Psychiatry 67: 974-982.
2009
126) HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A,
Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen
YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, Edo J, Fuchareon
S, Ghang H, Gojobori T, Han J, Ho SF, Hoh BP, Huang W, Inoko H, Jha P,
Jinam TA, Jin L, Jung J, Kangwanpong D, Kampuansai J, Kennedy GC, Khurana
P, Kim HL, Kim K, Kim S, Kim WY, Kimm K, Kimura R, Koike T, Kulawonganunchai
S, Kumar V, Lai PS, Lee JY, Lee S, Liu ET, Majumder PP, Mandapati KK, Marzuki
S, Mitchell W, Mukerji M, Naritomi K, Ngamphiw C, Niikawa N, Nishida N,
Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon
HB, Phipps ME, Png E, Sakaki Y, Salvador JM, Sandraling Y, Scaria V, Seielstad
M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, Suryadi H, Suzuki
Y, Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang
Y, Wang H, Wu JY, Xiao H, Xu S, Yang JO, Shugart YY, Yoo HS, Yuan W, Zhao
G, Zilfalil BA; Indian Genome Variation Consortium (2009) Mapping human
genetic history in Asia. Science 326: 1541-1545.
125) Naka I, Patarapotikul J, Tokunaga K, Hananantachai H, Tsuchiya N,
Ohashi J (2009) A replication study of the association between the IL12B
promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.
Malaria Journal 8: 290.
124) Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai
H, Tsuchiya N, Ohashi J (2009) Identification of a haplotype block in the
5q31 cytokine gene cluster associated with the susceptibility to severe
malaria. Malaria Journal 8: 232.
123) Noranate N, Prugnolle F, Jouin H, Tall A, Marrama L, Sokhna C, Ekala
MT, Guillotte M, Bischoff E, Bouchier C, Patarapotikul J, Ohashi J, Trape
JF, Rogier C, Mercereau-Puijalon O (2009) Population diversity and antibody
selective pressure to Plasmodium falciparum MSP1 block2 locus in an African
malaria-endemic setting. BMC Microbiology 9: 219.
122) Makino H, Shimizu I, Murao S, Kondo S, TabaraY, Fujiyama M, Fujii
Y, Takada Y, Nakai K, Izumi K, Ohashi J, Kawamura R, Yamauchi J, Takata
Y, Nishida W, Hashiramoto M, Onuma H, Osawa H (2009) A pilot study suggests
that the G/G genotype of resistin single nucleotide polymorphism at -420
may be an independent predictor of a reduction in fasting plasma glucose
and insulin resistance by pioglitazone in type 2 diabetes. Endocrine Journal
56: 1049-1058.
121) Naka I, Patarapotikul J, Hananantachai H, Tokunaga K, Tsuchiya N,
Ohashi J (2009) IFNGR1 polymorphisms in Thai malaria patients. Infection,
Genetics and Evolution 9: 1406-1409.
120) Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara
L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y,
Tsunoda T, Tokunaga K, Ohashi J (2009) FGFR2 is associated with hair thickness
in Asian populations. Journal of Human Genetics 54: 461-465.
119) Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, Ohashi J, Hikami K, Kawamoto
M, Fujimoto M, Takehara K, Sato S, Hara M, Tsuchiya N (2009) Association
of a functional polymorphism in the IRF5 region with systemic sclerosis
in a Japanese population. Arthritis & Rheumatism 60: 1845-1850.
118) Ohashi J (2009) A practical case-control association test for detecting
a susceptibility allele at a copy number variation locus. Journal of Human
Genetics 54: 169-173.
117) Osawa H, Tabara Y, Kawamoto R, Ohashi J, Ochi M, Onuma H, Nishida
W, Yamada K, Nakura J, Miki T, Makino H, Kohara K (2009) PPARgamma Pro12Ala
Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated
with plasma resistin in the Japanese general population. Clinical Endocrinology
71: 341-345.
116) Nantakomol D, Imwong M, Soontarawirat I, Kotjanya D, Khakhai C, Ohashi
J, Nuchnoi P (2009) The absolute counting of red cell-derived microparticles
with red cell bead by flow rate based assay. Cytometry Part B: Clinical
Cytometry 76B: 191-198.
115) Ito I, Kawasaki A, Ohashi J, Hayashi T, Matsumoto I, Ito S, Tsutsumi
A, Hom G, Graham RR, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya
N (2009) Replication of the Association between C8orf13-BLK Region and
Systemic Lupus Erythematosus in a Japanese Population. Arthritis &
Rheumatism 60: 553-558.
114) Mahasirimongkol S, Yanai H, Nishida N, Ridruechai C, Matsushita I,
Ohashi J, Summanapan S, Yamada N, Moolphate S, Chuchotaworn C, Chaiprasert
A, Manosuthi W, Kantipong P, Kanitwittaya S, Sura T, Khusmith S, Tokunaga
K, Sawanpanyalert P, Keicho N (2009) Genome-wide SNP-based linkage analysis
of tuberculosis in Thais. Genes and Immunity 10: 77-83.
2008
113) Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, Matsumoto
I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham RR, Hom G, Takasaki Y,
Hashimoto H, Behrens TW, Sumida T, Tsuchiya N (2008) Role of STAT4 polymorphisms
in systemic lupus erythematosus in a Japanese population: a case-control
association study of STAT1-STAT4 region. Arthritis Research & Therapy
10: R113.
112) Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A,
Shimada M, Morishita S, Shigeta T, Lin L, Hong SC, Faraco J, Shin YK, Jeong
JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, Tokunaga K (2008) Variant
between CPT1B and CHKB associated with susceptibility to narcolepsy. Nature
Genetics 40: 1324-1328.
111) Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai
H, Naka I, Putaporntip C, Jongwutiwes S, Tokunaga K (2008) A Functional
SNP in the CR1 Promoter Region Contributes to Protection against Cerebral
Malaria. The Journal of Infectious Diseases 198: 1880-1891.
110) Fujimoto A, Ohashi J, Nishida N, Miyagawa T, Morishita Y, Tsunoda
T, Kimura R, Tokunaga K (2008) A replication study confirmed the EDAR gene
to be a major contributor to population differentiation regarding head
hair thickness in Asia. Human Genetics 124: 179-185.
109) Miyagawa T, Nishida N, Ohashi J, Kimura R, Fujimoto A, Kawashima M,
Koike A, Sasaki T, Tanii H, Otowa T, Momose Y, Nakahara Y, Gotoh J, Okazaki
Y, Tsuji S, Tokunaga K (2008) Appropriate data cleaning methods for genome-wide
association study. Journal of Human Genetics 53: 886-893.
108) Shiota S, Tochigi M, Shimada H, Ohashi J, Kasai K, Kato N, Tokunaga
K, Sasaki T (2008) Association and interaction analyses of NRG1 and ERBB4
genes with schizophrenia in a Japanese population. Journal of Human Genetics
53: 929-935.
107) Kurashina K, Yamashita Y, Ueno T, Koinuma K, Ohashi J, Horie H, Miyakura
Y, Hamada T, Haruta H, Hatanaka H, Soda M, Choi YL, Takada S, Yasuda Y,
Nagai H, Mano H (2008) Chromosome copy number analysis in screening for
prognosis-related genomic regions in colorectal carcinoma. Cancer Science
99: 1835-1840.
106) Kimura R, Ohashi J, Matsumura Y, Nakazawa M, Inaoka T, Ohtsuka R,
Osawa M, Tokunaga K (2008) Gene Flow and Natural Selection in Oceanic Human
Populations, Inferred from Genome-wide SNP Typing. Molecular Biology and
Evolution 25: 1750-1761.
105) Nuchnoi P, Ohashi J, Naka I, Nacapunchai D, Tokunaga K, Nishida N,
Patarapotikul J (2008) Linkage Disequilibrium Structure of the 5q31-33
Region in a Thai Population. Journal of Human Genetics 53: 850-856.
104) Naka I, Ohashi J, Nuchnoi P, Hananantachai H, Looareesuwan S, Tokunaga
K ,Patarapotikul J (2008) Lack of association of the HbE variant with protection
from cerebral malaria in Thailand. Biochemical Genetics 46: 708-711.
103) Hirayasu K, Ohashi J, Tanaka H, Kashiwase K, Ogawa A, Takanashi M,
Satake M, Jia GJ, Chimge NO, Sideltseva EW, Tokunaga K, Yabe T (2008) Evidence
for natural selection on leukocyte immunoglobulin-like receptors for HLA
class I in Northeast Asians. American Journal of Human Genetics 82: 1075-1083.
102) Nuchnoi P, Ohashi J, Kimura R, Hananantachai H, Naka I, Krudsood S,
Looareesuwan S, Tokunaga K, Patarapotikul J (2008) Significant association
between TIM1 promoter polymorphisms and protection against cerebral malaria
in Thailand. Annals of Human Genetics72: 327-336.
101) Fujimoto A, Kimura R, Ohashi J, Omi K, Yuliwulandari R, Batubara L,
Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Furusawa
T, Nakazawa M, Ohtsuka R, Tokunaga K (2008) A scan for genetic determinants
of human hair morphology: EDAR is associated with Asian hair thickness.
Human Molecular Genetics 17: 835-843.
100) Murao S, Kondo S, Ohashi J, Fujii Y, Shimizu I, Fujiyama M, Ohno K,
Takada Y, Nakai K, Yamane Y, Osawa H, Makino H (2008) Anti-thyroid peroxidase
antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell
failure in patients with latent autoimmune diabetes in adults (LADA) -a
five year follow-up of the Ehime study-. Diabetes Research and Clinical
Practice 80: 114-121.
99) Kato C, Tochigi M, Ohashi J, Koishi S, Kawakubo Y, Yamamoto K, Matsumoto
H, Hashimoto O, Kim S-Y, Watanabe K, Kano Y, Nanba E, Kato N, Sasaki T
(2008) Association study of the 15q11-q13 maternal expression domain in
Japanese autistic patients. American Journal of Medical Genetics Part B
(Neuropsychiatric Genetics) 147B: 1008-1012.
98) Osawa H, Yamada K, Tabara Y,Ochi M, Onuma H, Nishida W, Shimizu I,
Kawamoto R, Fujii Y, Miki T, Ohashi J, Makino H (2008) The G/G genotype
of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase
1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the
specific binding of AP2a. Clinical Endocrinology 69: 36-44.
97) Osawa H, Ochi M, Tabara Y, Kato K, Yamauchi J, Takata Y, Nishida W,
Onuma H, Shimizu I, Fujii Y, Miki T, Ohashi J, Makino H (2008) Serum resistin
is positively correlated with the accumulation of metabolic syndrome factors
in type 2 diabetes. Clinical Endocrinology 69: 74-80.
96) Kato K, Osawa H, Ochi M, Kusunoki Y, Ebisui O, Ohno K, Ohashi J, Shimizu
I, Fujii Y, Tanimoto M, Makino H (2008) Serum total and high molecular
weight adiponectin is correlated with the severity of diabetic retinopathy
and nephropathy. Clinical Endocrinology 68: 442-449.
95) Osawa H, Tabara Y, Kawano R, Ohashi J, Ochi M, Onuma H, Nishida W,
Yamada K, Nakura J, Kohara K, Miki T, Makino H (2008) Plasma resistin,
associated with single nucleotide polymorphism -420, is correlated with
insulin resistance, lower HDL, and high sensitivity CRP in the Japanese
general population. Diabetes Care 30: 1501-1506.
94) Tochigi M, Kato C, Ohashi J, Koishi S, Kawakubo Y, Yamamoto K, Matsumoto
H, Hashimoto O, Kim S-Y, Watanabe K, Kano Y, Nanba E, Kato N, Sasaki T
(2008) No association between the ryanodine receptor 3 gene and autism
in a Japanese population. Psychiatry and Clinical Neurosciencse 62: 341-344.
93) Kawasaki A, Kyogoku C, Ohashi J, Miyashita R, Hikami K, Kusaoi M, Tokunaga
K, Takasaki Y, Hashimoto H, Behrens TW, Tsuchiya N (2008) Association of
interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus
erythematosus in Japanese: Support for a crucial role of intron 1 polymorphisms.
Arthritis & Rheumatism 58: 826-834.
92) Shi L, Ogata S, Yu JK, Ohashi J, Yu L, Shi L, Sun H, Lin K, Huang XQ,
Matsushita M, Horai S, Muramatsu M, Chu JY, Tokunaga K (2008) Distribution
of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest
China. Human Immunology 69: 58-65.
91) Yamauchi J, Osawa H, Takasuka T, Ochi M, Murakami A, Nishida W, Onuma
H, Takata Y, Tabara Y, Miki T, Ohashi J, Makino H (2008) Serum resistin
is reduced by glucose and meal loading in healthy human subjects. Metabolism
57: 149-156.
90) Hoa BK, Hang NTL, Kashiwase K, Ohashi J, Lien LT, Horie T, Shojima
J, Hijikata M, Sakurada S, Satake M, Tokunaga K, Sasazuki T, Keicho N (2008)
HLA-A, B, C, DRB1 and DQB1 alleles and haplotypes in the Kinh population
in Vietnam. Tissue Antigens 71: 127-134.
2007
89) Ohashi J, Naka I, Kimura R, Natsuhara K, Yamauchi T, Furusawa T, Nakazawa
N, Ataka Y, Patarapotikul J, Nuchnoi P, Tokunaga K, Ishida T, Inaoka T,
Matsumura Y, Ohtsuka R (2007) FTO polymorphisms in Oceanic populations.
Journal of Human Genetics 52: 1031-1035.
88) Suga T, Ishikawa A, Kohda M, Otsuka Y, Yamada S, Yamamoto N, Shibamoto
Y, Ogawa Y, Nomura K, Sho K, Omura M, Sekiguchi K, Kikuchi Y, Michikawa
Y, Noda S, Sagara M, Ohashi J, Yoshinaga S, Mizoe J, Tsujii H, Iwakawa
M, Imai T (2007) Haplotype-based analysis of genes associated with risk
of adverse skin reactions after radiotherapy in breast cancer patients.
International Journal of Radiation Oncology Biology Physics 69: 685-693.
87) Ochi M, Osawa H, Hirota Y, Hara K, Tabara Y, Tokuyama Y, Shimizu I,
Kanatsuka A, Fujii Y, Ohashi J, Miki T, Nakamura N, Kadowaki T, Itakura
M, Kasuga M, Makino H (2007) Frequency of the G/G genotype of resistin
single nucleotide polymorphism at -420 appears to be increased in younger
onset type 2 diabetes. Diabetes 56: 2834-2838.
86) Naka I, Ohashi J, Patarapotikul J, Hananantachai H, Wilairatana P,
Looareesuwan S, Tokunaga K (2007) The genotypes of GYPA and GYPB carrying
the MNSs antigens are not associated with cerebral malaria. Journal of
Human Genetics 52: 476-479.
85) Kimura R, Fujimoto A, Tokunaga K, Ohashi J (2007) A practical genome
scan for population-specific strong selective sweeps that have reached
fixation. PLoS One 2: e286.
84) Osawa H, Ochi M, Kato K, Yamauchi J, Nishida W, Takata Y, Kawamura
R, Onuma H, Takasuka T, Shimizu I, Fujii Y, Ohashi J, Makino H (2007) Serum
resistin is associated with the severity of microangiopathies in type 2
diabetes. Biochemical and Biophysical Research Communications 355: 342-346.
83) Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Krudsood S, Looareesuwan
S, Tokunaga K (2007) Significant association between TNF-a (TNF) promoter
allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand. Tissue
Antigens 69: 277-280.
82) Kawasaki A, Tsuchiya N, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M,
Morimoto S, Matsuta K, Hashimoto H, Takasaki Y, Tokunaga K (2007) Role
of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus
erythematosus in Japanese. Rheumatology 46: 776-782.
81) Tamura Y, Kunugi H, Ohashi J, Hohjoh H (2007) Epigenetic aberration
of the human REELIN gene in psychiatric disorders. Molecular Psychiatry
12: 593-600.
80) Ogata S, Shi L, Matsushita M, Liang YU, Huang XQ, Lei SHI, Sun H, Ohashi
J, Muramatsu M, Tokunaga K, Chu JY (2007) Polymorphisms of HLA genes in
Maonan people in China. Tissue Antigens 69:154-160.
79) Choi YL, Tsukasaki K, O'neill MC, Yamada Y, Onimaru Y, Matsumoto K,
Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, Takada S, Aburatani H, Kamihira
S, Nakamura T, Tomonaga M, Mano H (2007) A genomic analysis of adult T-cell
leukemia. Oncogene 26: 1245-1255.
78) Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, Kato T,
Okazaki Y, Kato N, Tokunaga K, Sasaki T (2007) Association study between
the TNXB locus and schizophrenia in a Japanese population. American Journal
of Medical Genetics Part B (Neuropsychiatric Genetics) 144: 305-309.
2006
77) Ohashi J, Naka I, Toyoda A, Takasu M, Tokunaga K, Ishida T, Sakaki
Y, Hohjoh H (2006) Estimation of the species-specific mutation rates of
the DRB1 locus in human and chimpanzee. Tissue Antigens 68: 427-431.
76) Dechkum N, Hananantachai H, Patarapotikul J, Ohashi J, Krudsood S,
Looareesuwan S, Tokunaga K (2006) Monocyte Chemoattractant Protein 1 (MCP-1)
Gene Polymorphism Is Not Associated with Severe and Cerebral Malaria in
Thailand. Japanese Journal of Infectious Diseases 59: 239-244.
75) Tochigi M, Suga M, Ohashi J, Otowa T, Yamasue H, Kasai K, Kato T, Okazaki
Y, Kato N, Sasaki T (2006) No association between the metabotropic glutamate
receptor type 3 gene (GRM3) and schizophrenia in a Japanese population.
Schizophrenia Research 88:260-264.
74) Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, Kato T,
Okazaki Y, Kato N, Tokunaga K, Sasaki T (2006) Association study of the
dysbindin (DTNBP1) gene in schizophrenia from the Japanese population.
Neuroscience Research 56: 154-158.
73) Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P,
Tokunaga K, Tobe K, Nagai R, Kadowaki T (2006) Hepatocyte Nuclear Factor-4a
P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese
Population. Diabetes 55: 1260-1264.
72) Jalloh A, van Thien H, Ferreira MU, Ohashi J, Matsuoka H, Kanbe T,
Kikuchi A, Kawamoto F (2006) Sequence Variation in the T-Cell Epitopes
of the Plasmodium falciparum Circumsporozoite Protein among Field Isolates
Is Temporally Stable: a 5-Year Longitudinal Study in Southern Vietnam.
Journal of Clinical Microbiology 44: 1229-1235.
71) Horikoshi M, Hara K, Ohashi J, Miyake K, Tokunaga K, Ito C, Kasuga
M, Nagai R, Kadowaki T (2006) A Polymorphism in the AMPKa2 Subunit Gene
Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese
Population. Diabetes 55: 919-923.
70) Ohashi J, Naka I, Kimura R, Tokunaga K, Nakazawa M, Ataka Y, Ohtsuka
R, Inaoka T, Matsumura Y (2006) HLA-DRB1 polymorphism on Ha’ano Island
of the Kingdom of Tonga. Anthropological Science 114: 193-198.
69) Hirayasu K, Ohashi J, Kashiwase K, Takanashi M, Satake M, Tokunaga
K, Yabe T. (2006) Long-term persistence of both functional and non-functional
alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus
suggests balancing selection. Human Genetics 119: 436-443.
68) Ohashi J, Naka I, Kimura R, Tokunaga K, Yamauchi T, Natsuhara K, Furusawa
T, Yamamoto R, Nakazawa M, Ishida T, Ohtsuka R. (2006) Polymorphisms in
the ABO blood group gene in three populations in New Georgia Islands, Solomon
Islands. Journal of Human Genetics 51: 407-411.
67) Ohashi J, Naka I, Tokunaga K, Inaoka T, Ataka Y, Nakazawa M, Matsumura
Y, Ohtsuka R. (2006) Mitochondrial DNA variation suggests extensive gene
flow from Polynesian ancestors to indigenous Melanesians in the northwestern
Bismarck archipelago. American Journal of Physical Anthropology 130: 551-556.
66) Shi L, Xu SB, Ohashi J, Sun H, Yu JK, Huang XQ, Tao YF, Yu L, Horai
S, Chu JY, Tokunaga K. (2006) HLA-A, HLA-B, and HLA-DRB1 alleles and haplotypes
in Naxi and Han populations in southwestern China (Yunnan province). Tissue
Antigens 67: 38-44.
2005
65) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Tangpukdee N, Looareesuwan
S, Tokunaga K (2005) A functional polymorphism in the IL1B gene promoter,
IL1B -31C>T, is not associated with cerebral malaria in Thailand. Malaria
Journal 4:38.
64) Osawa H, Onuma H, Ochi M, Murakami A, Yamauchi J, Takasuka T, Tanabe
F, Shimizu I, Kato K, Nishida W, Yamada K, Tabara Y, Yasukawa M, Fujii
Y, Ohashi J, Miki T, Makino H (2005) Resistin SNP-420 determines its monocyte
mRNA and serum levels inducing type 2 diabetes. Biochemical Biophysical
and Research Communications 335: 596-602.
63) Nam MH, Hijikata M, Tuan le A, Lien LT, Shojima J, Horie T, Nakata
K, Matsushita I, Ohashi J, Tokunaga K, Keicho N. (2005) Variations of the
CFTR gene in the Hanoi-Vietnamese. American Journal of Medical Genetics
A 136: 249-253.
62) Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi
J, Froguel P, Tokunaga K, Nagai R, Kadowaki T. (2005) Absence of an association
between the polymorphisms in the genes encoding adiponectin receptors and
type 2 diabetes. Diabetologia. 48: 1307-1314.
61) Zhang X, Tochigi M, Ohashi J, Maeda K, Kato T, Okazaki Y, Kato N, Tokunaga
K, Sawa A, Sasaki T. (2005) Association study of the DISC1/TRAX locus with
schizophrenia in a Japanese population. Schizophrenia Research 79: 175-180.
60) Tanaka G, Matsushita I, Ohashi J, Tsuchiya N, Ikushima S, Oritsu M,
Hijikata M, Nagata T, Yamamoto K, Tokunaga K, Keicho N (2005) Evaluation
of microsatellite markers in association studies: a search for an immune-related
susceptibility gene in sarcoidosis. Immunogenetics 56: 861-870.
59) Ohashi J, Clark AG (2005) Application of the stepwise focusing method
to optimization of the cost-effectiveness of genome-wide association study
with limited research budget for genotyping and phenotyping. Annals of
Human Genetics 69:323-328
58) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan
S, Clark AG, Tokunaga K (2005) Strong linkage disequilibrium of a HbE variant
with the (AT)9(T)5 repeat in the BP1 binding site upstream of the b-globin
gene in Thai population. Journal of Human Genetics 50: 7-11.
57) Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Looareesuwan S,
Tokunaga K (2005) Polymorphisms of HLA-B and HLA-DRB1 genes in Thai malaria
patients. Japanese Journal of Infectious Diseases 58: 25-28.
2004
56) Akesaka T, Lee SG, Ohashi J, Bannai M, Tsuchiya N, Yoon Y, Tokunaga
K, Song K (2004) Comparative study of the haplotype structure and linkage
disequilibrium of chromosome 1p36.2 region in the Korean and Japanese populations.
Journal of Human Genetics 49: 603-609.
55) Hitomi Y, Tsuchiya N, Kawasaki A, Kyogoku C, Ohashi J, Suzuki T, Fukazawa
T, Bejrachandra S, Siriboonrit U, Chandanayingyong D, Suthipinittharm P,
Tsao BP, Hashimoto H, Honda ZI, Tokunaga K (2004) CD72 polymorphisms associated
with alternative splicing modify susceptibility to human systemic lupus
erythematosus through epistatic interaction with FCGR2B. Human Molecular
Genetics 13: 2907-2917.
54) Itoyama S, Keicho N, Quy T, Phi NC, Long HT, Ha LD, Ban VV, Ohashi
J, Hijikata M, Matsushita I, Kawana A, Yanai H, Kirikae T, Kuratsuji T,
Sasazuki T (2004) ACE1 Polymorphism and Progression of SARS. Biochemical
Biophysical and Research Communications 323: 1124-1129.
53) Osawa H, Yamada K, Onuma H, Murakami A, Ochi M,Hiroko Kawata, Nishimiya
T, Niiya T, Shimizu I, Nishida W, Hashiramoto M, Kanatsuka A, Fujii Y,
Ohashi J, Makino M (2004) The G/G Genotype of a Resistin Single-Nucleotide
Polymorphism at -420 Increases Type 2 Diabetes Mellitus Susceptibility
by Inducing Promoter Activity through Specific Binding of Sp1/3. American
Journal of Human Genetics 75: 678-686.
52) Murao S, Makino H, Kaino Y, Konoue E, Ohashi J, Kida K, Fujii Y, Shimizu
I, Kawasaki E, Fujiyama M, Kondo S, Tanaka K, Tarumi Y, Seto I, Kato K,
Ohno K, Ebisui O, Takada Y, Tanabe K, Takemoto K, Onuma H, Nishimiya T,
Osawa H (2004) Differences in the Contribution of HLA-DR and -DQ Haplotypes
to Susceptibility to Adult-Onset and Childhood-Onset Type 1 Diabetes in
Japanese Patients. Diabetes 53: 2684-2690.
51) Kamio K, Matsushita I, Tanaka G, Ohashi J, Hijikata M, Nakata K, Tokunaga
K, Azuma A, Kudoh S, Keicho N (2004) Direct determination of MUC5B promoter
haplotypes based on the method of single-strand conformation polymorphism
and their statistical estimation. Genomics 84: 613-622.
50) Sato-Takeda M, Ihn H, Ohashi J, Tsuchiya N, Ishikawa Y, Satake M, Arita
H, Tamaki K, Hanaoka K, Tokunaga K, Yabe T (2004) The human histocompatibility
leukocyte antigen (HLA) haplotype is associated with the onset of postherpetic
neuralgia after herpes zoster. Pain 110: 329-336.
49) Araki J, Ohashi J, Muramatsu M (2004) Application of discordant sib-pair
linkage analysis for mapping minor histocompatibility antigen loci in a
novel graft-versus-host-disease model. Tissue Antigens 64: 243-250.
48) Ohki-Kaneda R, Ohashi J, Yamamoto K, Ueno S, Ota J, Choi YL, Koinuma
K, Yamashita Y, Misawa Y, Fuse K, Ikeda U, Shimada K, Mano H (2004) Cardiac
function-related gene expression profiles in human atrial myocytes. Biochemical
Biophysical Research Communications 320: 1328-1336.
47) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan
S, Clark AG, Tokunaga K (2004) Extended linkage disequilibrium surrounding
the hemoglobin E variant due to malarial selection. American Journal of
Human Genetics 74: 1198-1208.
46) Tochigi M, Zhang X, Umekage T, Ohashi J, Kato C, Marui T, Otowa T,
Hibino H, Otani T, Kohda K, Liu S, Kato N, Tokunaga K, Sasaki T (2004)
Association of six polymorphisms of the NOTCH4 gene with schizophrenia
in the Japanese population. American Journal of Medical Genetics 128B:
37-40.
45) Chu ZT, Tsuchiya N, Kyogoku C, Ohashi J, Qian YP, Xu SB, Mao CZ, Chu
JY, Tokunaga K (2004) Association of Fcg receptor IIb polymorphism with
susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility
gene in the Asian populations. Tissue Antigens 63: 21-27.
44) Choi YL, Makishima H, Ohashi J, Yamashita Y, Ohmine K, Ohki R, Wada
T, Koinuma K, Ota J, Isobe Y, Ishida F, Ymauchi K, Oshimi K, Mano H (2004)
DNA microarray analysis of natural killer cell-type lymphoproliferative
disease of granular lymphocytes with purified CD3-CD56+ fractions. Leukemia
18: 556-565.
43) Ohashi J, Naka I, Ohtsuka R, Inaoka T, Ataka Y, Nakazawa M, Tokunaga
K, Matsumura Y (2004) Molecular polymorphism of ABO blood group gene in
Austronesian and Non-Austronesian populations in Oceania. Tissue Antigens
63: 355-361.
2003
42) Ochi M, Osawa H, Onuma H, Murakami A, Nishimiya T, Shimada F, Kato
K, Shimizu I, Shishino K, Murase M, Fujii Y, Ohashi J, Makino H (2003)
The absence of evidence for major effects of the frequent SNP +299G>A
in the resistin gene on susceptibility to insulin resistance syndrome associated
with Japanese type 2 diabetes. Diabetes Research and Clinical Practice
61: 191-198.
41) Ohashi J, Maruya E, Tokunaga K, Saji H (2003) Power of association
test for detection minor histocompatibility gene causing graft-versus-host
disease following bone marrow transplantation. Journal of Human Genetics
48: 502-507.
40) Ohashi J, Tokunaga K (2003) The power of genome-wide linkage disequilibrium
(LD) testing using microsatellite markers. Journal of Human Genetics 48:
487-491.
39) Hohjoh H, Ohashi J, Takasu M, Nishioka T, Ishida T, Tokunaga K (2003)
Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701
lineage after the separation of the human and chimpanzee species. Immunogenetics
54: 856-861.
38) Tarasenko O, Ohashi J, Ataka Y, Inaoka T, Ohtsuka R, Tokunaga K (2003)
HLA-DRB1 polymorphism of Balopa islanders in Papua New Guinea. Anthropological
Science 111: 157-164.
37) Ataka Y, Ohtsuka R, Inaoka T, Kawabata M, Ohashi J, Matsushita M, Tokunaga
K, Kano S, Suzuki M (2003) Variation in malaria endemicity in relation
to microenvironmental conditions in the Admiralty Islands, Papua New Guinea.
Asia-Pacific Journal of Public Health 13: 85-90.
36) Osawa H, Niiya T, Onuma H, Murakami A, Ochi M, Nishimiya T, Ogura T,
Kato K, Shimizu I, Fujii Y, Ohashi J, Yamada K, Liang SJ, Manganiello VC,
Fujita-Yamaguchi Y, Makino H (2003) Systematic search for single nucleotide
polymorphisms (SNPs) in the 5’flanking region of the human phosphodiesterase
3B gene: absence of evidence for major effects of identified polymorphisms
on susceptibility to Japanese type 2 diabetes. Molecular Genetics and Metabolism
79: 43-51.
35) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2003) A single nucleotide substitution from C to T at position
-1055 in the IL-13 promoter is associated with protection from severe malaria
in Thailand. Genes and Immunity 4: 528-531.
34) Naka I, Ohashi J, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2003) Genetic variants of b-globin gene in Thai malaria patients.
Southeast Asian Journal of Tropical Medicine and Public Health 34: 29-31.
33) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan
S, Tokunaga K (2003) CD36 polymorphism is associated with protection from
cerebral malaria. American Journal of Human Genetics 72: 364-374.
32) Osawa H, Onuma H, Murakami A, Ochi M, Mishimiya T, Kato K, Shimizu
I, Fujii Y, Ohashi J, Makino H (2003) Systematic search for single nucleotide
polymorphisms (SNPs) in the FOXC2 gene: The Absence of evidence for the
association of three frequent SNPs and four common haplotypes with Japanese
type 2 diabetes. Diabetes 52: 562-567.
2002
31) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan
S, Tokunaga K (2002) Absence of Association between the Fcg receptor IIIA-176F/V
Polymorphism and the Severity of Malaria in Thai. Japanese Journal of Infectious
Diseases 55: 167-169.
30) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan
S, Tokunaga K (2002) Fcg receptor IIA and IIIB polymorphisms are associated
with susceptibility to cerebral malaria. Parasitology International 51:
361-366.
29) Tochigi M, Ohashi J, Umekage T, Koda K, Hibino H, Otowa T, Marui T,
Masui K, Sugahara Y, Kanamori R, Juji T, Kato N, Tokunaga K, Sasaki T (2002)
HLA-A specificities and its relation with season of birth in Japanese patients
with schizophrenia. Neuroscience Letters 329: 201-204.
28) Ohashi J, Tokunaga K (2002) The expected power of genome-wide linkage
disequilibrium testing using single nucleotide polymorphism markers for
detecting a low-frequency disease variant. Annals of Human Genetics 66:
297-306.
27) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2002) Significant association of longer forms of CCTTT microsatellite
repeat in inducible nitric oxide synthase (iNOS) promoter with severe malaria
in Thailand. The Journal of Infectious Diseases 186: 578-581.
26) Sato M, Ohashi J, Tsuchiya N, Kashiwase K, Ishikawa Y, Arita H, HanaokaK,
Tokunaga K, Yabe T (2002) Association of HLA-A*3303-B*4403-DRB1*1302 haplotype,
but not of TNFa promoter and NKp30 polymorphism, with postherpetic neuralgia
(PHN) in the Japanese population. Genes and Immunity 3: 477-481.
25) Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, Shimizu
I, Fujii Y, Ohashi J, Makino H (2002) Systematic search for single nucleotide
polymorphisms in the resistin gene. The absence of evidence for the association
of three identified single nucleotide polymorphisms with Japansese type
2 diabetes. Diabetes 51: 863-866.
2001
24) Osawa H, Ochi M, Nishimiya T, Onuma H, Nakamaru K, Murakami A, Kato
K, Shimizu I, Fujii Y, Ohashi J, Makino H (2001) A systematic search for
single nucleotide polymorphisms (SNPs) in the insulin receptor gene: Association
of an sSNP with hyperlipidemia in Japanese type 2 diabetic subjects. Clinical
Genetics 60: 479-481.
23) Ohashi J, Naka I, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2001) Absence of association between the allele coding methionine
at position 29 in the N-terminal domain of ICAM-1 (ICAM-1Kilifi) and severe
malaria in the northwest of Thailand. Japanese Journal of Infectious Diseases
54: 114-116.
22) Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga
K, Yabe T (2001) Identification of novel single nucleotide substitutions
in the NKp30 gene expressed in human natural killer cells. Tissue Antigens
58: 255-258.
21) Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, Shimizu
I, Fujii Y, Ohashi J, Makino H (2001) Systematic search for single nucleotide
polymorphisms in the Insulin gene: evidence for a high frequency of -23T>A
in Japanese subjects. Biochemical and Biophysical Research Communications
286:451-455.
20) Ohashi J, Tokunaga K (2001) Power of genomewide association studies
of complex disease genes: Statistical limitation of indirect approaches
using SNP markers. Journal of Human Genetics 46: 478-482.
19) Ohashi J, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M,
Tokunaga K (2001) Comparison of statistical power between 2 × 2 allele
frequency and allele positivity tables in case-control studies of complex
disease genes. Annals of Human Genetics 65: 197-206.
18) Hananantachai H, Patarapotikul J, Looareesuwan S, Ohashi J, Naka I,
Tokunaga K (2001) Lack of association of -308A/G TNFA promoter and 196R/M
TNFR2 polymorphisms with disease severity in Thai adult malaria patients.
American Journal of Medical Genetics 102: 391-392.
17) Lin M, Chu CC, Chang SL, Lee JH, Loo HH, Akaza T, Juji T, Ohashi J,
Tokunaga K (2001) The origin of Minnan and Hakka, the so-called “Taiwanese”,
inferred by HLA study. Tissue Antigens 57: 192-199.
16) Tarasenko O, Ohashi J, Kitaev M, Razorilova S, Ardiyants A, Kutukeev
T, Alisherov A, Toktorgazieva K, Tokunaga K (2001) HLA-DRB1 gene polymorphism
in the Kyrgyz population. MHC 8:40-46.
2000
15) Tarasenko O, Ohashi J, Kitaev M, Alisherov A, Tyurebaeva B, Kutukeev
T, Tokunaga K (2000) Polymorphisms of HLA-A and -B genes in the Kyrgyz
population. Anthropological Science 108:293-303.
14) Ohashi J, Tokunaga K (2000) Computer simulation analysis suggests weak
balancing selection operative at the MICA locus. Hereditas 131:25-28.
13) Tsuchiya N, Komata T, Matsushita M, Ohashi J, Tokunaga K (2000) New
single nucleotide polymorphisms in the coding region of human TNFR2. Genes
& Immunity 1:501-503.
12) Wu MS, Tani K, Sugiyama H, Hibino H, Izawa K, Tanabe T, Nakazaki Y,
Ohashi J, Hohjoh H, Iseki T, Tojo A, Nakamura Y, Tanioka Y, Tokunaga K,
Asano S (2000) MHC (Major Histocompatibility Complex) -DRB genes and polymorphisms
in Common Marmoset. Journal of Molecular Evolution 51:214-222.
11) Ohashi J, Tokunaga K (2000) Sojourn times and substitution rate at
overdominant and linked neutral loci. Genetics 155:921-927.
10) Ohashi J, Yoshida M, Ohtsuka R, Nakazawa M, Juji T, Tokunaga K (2000)
Analysis of HLA-DRB1 polymorphism in Gidra living in South New Guinea.
Human Biology 72:337-347.
9) Shibue T, Tsuchiya N, Komata T, Matsushita M, Shiota M, Ohashi J, Wakui
M, Matsuta K, Tokunaga K (2000) Tumor necrosis factor a 5’-flanking region,
TNF receptor II and HLA-DRB1 polymorphisms in Japanese patients with rheumatoid
arthritis. Arthritis & Rheumatism 43:753-757.
8) Keicho N, Ohashi J, Tamiya G, Nakata K, Taguchi Y, Azuma A, Ohishi N,
Emi M, Park MH, Inoko H, Tokunaga K, Kudoh S (2000) Fine localization of
a major disease-susceptibility locus for diffuse panbronchiolitis. American
Journal of Human Genetics 66:501-507.
7) Bannai M, Ohashi J, Harihara S, Mitomi Y, Takahashi Y, Juji T, Omoto
K, Tokunaga K (2000) Analysis of HLA genes and haplotypes in Ainu (from
Hokkaido, northern Japan) supports the premise that they decent from Upper
Paleolithic populations of East Asia. Tissue Antigens 55:128-139.
6) Lin M, Chu CC, Lee HL, Chang SL, Ohashi J, Tokunaga K, Akaza T, Juji
T (2000) Heterogeneity of Taiwan’s indigenous population: possible relation
to prehistoric Mongoloid dispersals. Tissue Antigens 55: 1-9.
1999
5) Matsushita M, Tsuchiya N, Nakayama T, Ohashi J, Shibue T, Shiota M,
Oka T, Yamane A, Tokunaga K (1999) Allele typing of human TNFA 5’-flanking
region using PCR-PHFA (preferential homoduplex formation assay): linkage
disequilibrium with HLA class I and class II genes in Japanese. Tissue
Antigens 54: 478-484.
4) Hatta Y, Tsuchiya N, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K,
Juji T, Tokunaga K (1999) Association of Fcg receptor IIIB, but not of
Fcg receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus
in Japanese. Genes and Immunity 1: 53-60.
3) Hohjoh H, Nakayama T, Ohashi J, Miyagawa T, Tanaka H, Akaza T, Honda
Y, Juji T, and Tokunaga K (1999) Significant association of a single nucleotide
polymorphism in the tumor necrosis factor-alpha (TNF-a) gene promoter with
human narcolepsy. Tissue Antigens 54: 138-145.
2) Ohashi J, Tokunaga K (1999) Selecting contingency table in population-based
association study: allele frequency or positivity? Journal of Human Genetics
44: 246-248.
1) Hatta Y, Ohashi J, Imanishi T, Kamiyama H, Iha M, Shimabukuro T, Ogawa
A, Tanaka H, Akaza T, Gojobori T, Juji T, Tokunaga K (1999) HLA genes and
haplotypes in Ryukyuan suggest recent gene flow to the Okinawa islands.
Human Biology 71: 353-365.
Original article (Japanese)
1) 大橋 順 2012 Extended Haplotype Homozygosity (EHH)を用いる正の自然選択検出法の検出力比較.
統計数理 60: 317-325.
Review and book (English)
5) Tsuchiya N, Ohashi J (2015) Human immune system diversity and its implications
in diseases. Journal of Human Genetics 60: 655-656.
4) Kimura R, Ohashi J (2008) Identifying Regions of the Human Genome that
Exhibit Evidence for Positive Selection. Handbook of Human Molecular Evolution,
2 Volume Set. Cooper DN, Kehrer-Sawatzki eds. Wiley. 2008.
3) Tsuchiya N, Ohashi J, Tokunaga K (2002) Variations in immune response
genes and their associations with multifactorial immune disorders. Immunological
reviews 190: .169-181.
2) Tokunaga K, Ohashi J, Bannai M, Juji T (2001) Genetic Link between
Asians and Native Americans: Evidence from HLA genes and haplotypes. Human
Immunology 62:1001-1008.
1) Komatsu-Wakui M, Ohashi J, Tokunaga K, Ishikawa Y, Kashiwase K, Ando
H, Shiina T, Geraghty DE, Inoko H, Juji T (2000) MIC-A polymorphism and
a MIC-A-MIC-B null haplotype with~100-kb deletion. Major Histocompatibility
Complex. Kasahara M (ed.) Springer. pp 480-486.
特任助教 中 伊津美 (Izumi NAKA)
略歴
2022年04月 東京大学大学院理学系研究科生物科学専攻助教
2021年05月 東京大学大学院理学系研究科生物科学専攻特任助教
2014年10月 東京大学大学院理学系研究科生物科学専攻特任研究員
2014年04月 筑波大学医学医療系研究員
2013年04月 日本学術振興会特別研究員(PD(DC2からの変更))
2013年03月 博士(医学)学位取得(筑波大学)
2012年04月 日本学術振興会特別研究員(DC2)
2009年04月 筑波大学大学院人間総合科学研究科生命システム医学専攻入学
2008年11月 筑波大学医学系支援室(~2012年3月)
2000年04月 東京大学大学院医学系研究科人類遺伝学分野技術補佐員(~2008年10月)
業績
英文原著論文
2021
65) Maharani N, Soetadji A, Utari A, Naka I, Ohashi J, Mexitalia M. Cytochrome b-245 alpha chain gene variants and arterial function in Indonesian short stature children. Cardiology Research (in press).
64) Isshiki M, Naka I, Kimura R, Nishida N, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R, Ohashi J (2021) Admixture with indigenous people helps local adaptation: admixture-enabled selection in Polynesians. BMC Ecology and Evolution 21: 179.
63) Anzurez A, Naka I, Miki S, Hosoya-Nakayama K, Isshiki M, Watanabe
Y, Nakamura-Hoshi M, Seki S, Matsumura T, Takano T, Onodera T, Adachi Y,
Moriyama S, Terahara K, Tachikawa N, Yoshimura Y, Sasaki H, Horiuchi H,
Miyata N, Miyazaki K, Koga M, Ikeuchi K, Nagai H, Saito M, Adachi E, Yotsuyanagi
H, Kutsuna S, Kawashima A, Miyazato Y, Kinoshita N, Kouno C, Tanaka K,
Takahashi Y, Suzuki T, Matano T, Ohashi J, Kawana-Tachikawa A (2021) Association
of Human Leukocyte Antigen DRB1*09:01 with severe COVID-19. HLA 98: 37-42.
62) Mizuno F*, Naka I*, Ueda S, Ohashi J, Kurosaki K. The number of SNPs
required for distinguishing Japanese from other East Asians. Legal Medicine 49:101849. *co-first authors
2020
61) Arayasongsak U, Naka I, Ohashi J, Patarapotikul J, Nuchnoi P, Kalambaheti
T, Sa-Ngasang A, Chanama S, Chaorattanakawee S (2020) Genetic association
study of interferon lambda 3, CD27, and human leukocyte antigen-DPB1 with
dengue severity in Thailand. BMC Infectious Diseases 20: 948.
60) Isshiki M, Naka I, Watanabe Y, Nishida N, Kimura R, Furusawa T, Natsuhara
K, Yamauchi T, Nakazawa M, Ishida T, Eddie R, Ohtsuka R, Ohashi J (2020)
Admixture and natural selection shaped genomes of an Austronesian-speaking
population in the Solomon Islands. Scientific Reports 10: 6872.
59) Arayasongsak U, Naka I, Ohashi J, Patarapotikul J, Nuchnoi P, Kalambaheti
T, Sa-Ngasang A, Chanama S (2020) Interferon lambda 1 is associated with
dengue severity in Thailand. International Journal of Infectious Diseases
93: 121-125.
58) Okamura K, Abe Y, Naka I, Ohashi J, Yagami A, Matsunaga K, Kobayashi Y, Fukai K, Tanemura A, Katayama I, Masui Y, Ito A, Yamashita T, Nagai H, Nishigori C, Oiso N, Aoyama Y, Araki Y, Saito T, Hayashi M, Hozumi Y, Suzuki T (2020) Genome-wide association study identifies CDH13 as a susceptibility gene for rhododendrol-induced leukoderma. Pigment Cell and Melanoma Research 33: 826-833.
2019
57) Wah ST, Hananantachai H, Patarapotikul J, Naka I, Ohashi J, Nuchnoi P. (2019) microRNA-27a and microRNA-146a SNP in cerebral malaria. Molecular Genetics and Genomic Medicine 7(2):e00529
56) Watanabe Y, Naka I, Khor SS, Sawai H, Hitomi Y, Tokunaga K, Ohashi J, Analysis of whole Y-chromosome
sequences reveals the Japanese population history in the Jomon period.
Scientific Reports 9, 8556
2018
55) Isshiki M, Naka I, Nishida N, Furusawa T, Kimura R, Natsuhara K, Yamauchi
T, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R, Ohashi J (2018)
Association of an intronic SNP of the EFEMP1 gene with height in Tongans.
Meta Gene 17: 172-176.
54) Issiki M, Naka I, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa
M, Ishida T, Ohtsuka R, Ohashi J (2018) Mitochondrial DNA variations in
Austronesian-speaking populations living in the New Georgia Islands, the
Western Province of the Solomon Islands. Journal of Human Genetics 63:
101-104.
53) Ohashi J, Naka I, Furusawa T, Kimura R, Natsuhara K, Yamauchi T, Nakazawa
M, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R. Association study of CREBRF
missense variant (rs373863828:G>A; p.Arg457Gln) with levels of
serum lipid profile in the Pacific populations. Annals of Human Biology
45: 215-219.
2017
52) Issiki M, Naka I, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa
M, Ishida T, Ohtsuka R, Ohashi J. Mitochondrial DNA variations in Austronesian-speaking
populations living in the New Georgia Islands, the Western Province ofthe
Solomon Islands. Journal of Human Genetics 63: 101-104.
51) Naka I, Furusawa T, Kimura R, Natsuhara K, Yamauchi T, Nakazawa M,
Ataka Y, Ishida T, Inaoka T, Matsumura Y,Ohtsuka R, Ohashi J. A missense
variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in
Oceanic populations. Journal of Human Genetics 62: 847-849.
50) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa
M, Ishida T, Ohtsuka R, Ohashi J (2017) Polymorphisms Associated with a
Tropical Climate and Root Crop Diet Induce Susceptibility to Metabolic
and Cardiovascular Diseases in Solomon Islands. PLoS ONE 12: e0172676.
49) Yasukochi Y, Naka I, Patarapotikul J, Hananantachai H, Ohashi J (2017)
Evolution of Fseg/Cseg dimorphism in region III of Plasmodium falciparum
eba-175 gene. Infection, Genetics and Evolution 49: 251-255.
2016
48) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Wichukchinda N, Sawanpanyalert
P, Patarapotikul P, Tsuchiya N,Ohashi J (2016) Association of BAK1 single
nucleotide polymorphism with a risk for dengue hemorrhagic fever. BMC Medical
Genetics 17: 43
47) Ohashi J, Naka I, Hananantachai H, Patarapotikul J. Association of
PECAM1/CD31 polymorphisms with cerebral malaria. International Journal
of Molecular Epidemiology and Genetics 7: 87-94.
2015
46) Yasukochi Y, Naka I, Hananantachai H, Patarapotikul J, Ohashi J (2015)
Genetic evidence for contribution of human dispersal to the genetic diversity
of EBA-175 in Plasmodium falciparum. Malaria Journal 14: 293.
2014
45) Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Chanama S, Wichukchinda
N, Sawanpanyalert P, Patarapotikul P,Tsuchiya N, Ohashi J (2014) A replication
study confirms the association of GWAS-identified SNPs at MICB and PLCE1
in Thai patients with dengue shock syndrome. BMC Medical Genetics 15: 58.
44) Naka I, Patarapotikul J, Hananantachai H, Imai H, Ohashi J(2014)Association
of the endothelial protein C receptor (PROCR) rs867186-G allele with protection
from severe malaria. Malaria Journal 13:105 doi:10.1186/1475-2875-13-105.
43) Naka I, Patarapotikul J, Hananantachai H, Ohashi J(2014)Lack of Association
between BSG Polymorphisms and Cerebral Malaria. Japanese Journal of Infectious
Diseases 67(6):432-5.
42) Ohashi J, Suzuki Y, Naka I, Hananantachai H, Patarapotikul J(2014)Diversifying
selection on the thrombospondin-related adhesive protein (TRAP) gene of
Plasmodium falciparum in Thailand. PLoS ONE 9: e90522.
41) Sa-Ngasang A, Ohashi J, Naka I, Anantapreecha S, Sawanpanyalert P,
Patarapotikul J(2014)Association of IL1B -31C/Tand IL1RA variable number
of an 86-bp tandem repeat with Dengue Shock Syndrome in Thailand. The Journal
of InfectiousDiseases 210(1):138-145.
2013
40) Naka I, Ohashi J, Kimura R, Inaoka T, Matsumura Y (2013) Association
of ADRB2 polymorphism with triglyceride levelsinTongans. Lipids in Health
and Disease 12: 110.
39) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa
M, Ishida T, Inaoka T, Matsumura Y,AtakaY,Ohtsuka R, Ohashi J (2013) Hypertension
Susceptibility Gene Prevalence in the Pacific Islands and Associations
with Hypertension in Melanesia. Journal of Human Genetics 58: 142-149.
38) Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa
T, Natsuhara K, Yamauchi T, Nakazawa M,AtakaY, Ishida T, Inaoka T, Iwamoto
S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J.(2013) A functional SNP
upstream ofthe beta-2 adrenergic receptor gene (ADRB2) is associated with
obesity in Oceanic populations. International Journal of Obesity 37(9):1204-10
2012
37) Yamaguchi K, Watanabe C, Kawaguchi A, Sato T, Naka I, Shindo M, Moromizato
K, Aoki K, Ishida H, Kimura R. (2012)Association of melanocortin 1 receptor
gene (MC1R) polymorphisms with skin reflectance and freckles in Japanese.
J HumGenet.57(11):700-8.
36) Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A,
Takanashi M, Satake M, Nakajima K, Arase H,Tokunaga K, Patarapotikul J,
Yabe T. (2012) Significant association of KIR2DL3-HLA-C1 combination with
cerebral malariaand implications for co-evolution of KIR and HLA. PLoS
Pathogens 8: e1002565.
35) Naka I, Ohashi J, Kimura R, Furusawa T, Yamauchi T, Nakazawa M, Natsuhara
K, Ataka Y, Nishida N, Ishida T, Inaoka T,Matsumura Y, Ohtsuka R.(2012)DRD4
VNTR polymorphism in Oceanic populations. Anthropological Science 120(2):
151-155.
34) Kobayash K, Yuliwulandari R, Yanai H, Naka I, Lien L. T, Hang N. T.
L, Hijikata M, Keicho N, Tokunaga K (2012)Association of TLR polymorphisms
with development of tuberculosis in Indonesian females. Tissue Antigens
79, 190-197
2011
33) Kraisin S, Naka I, Patarapotikul J, Nantakomol D, Nuchnoi P, Hananantachai
H, Tsuchiya N, Ohashi J (2011) Association of ADAMTS13 polymorphism with
cerebral malaria. Malaria Journal. 10:366 doi:10.1186/1475-2875-10-366.
32) Naka I, Nishida N, Ohashi J (2011) No evidence for strong recent positive
selection favoring the 7 repeat allele of VNTR in the DRD4 gene. PLoS ONE
6: e24410.
31) Myles S, Lea RA, Ohashi J, Chambers GK, Weiss JG, Hardouin E, Engelken
J, Macartney-Coxson DP, Eccles DA, Naka I, Kimura R, Inaoka T, Matsumura
Y, Stoneking M (2011) Testing the thrifty gene hypothesis: the Gly482Ser
variant in PPARGC1A is associated with BMI in Tongans. BMC Medical Genetics.
12: 10.
30) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M,
Ishida T, Nishida N, Eddie R, Ohtsuka R, Ohashi J (2011) The Serum Leptin
Level and Body Mass Index in Melanesian and Micronesian Solomon Islanders:
Focus on Genetic Factors and Urbanization. American Journal of Human Biology.
23: 435-444.
29) Ohashi J, Naka I, Tsuchiya N (2011) The impact of natural selection
on an ABCC11 SNP determining earwax type. Molecular Biology and Evolution
28: 849-857.
2010
28) Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M,
Ishida T, Inaoka T, Matsumura Y, Ataka Y,NishidaN, Tsuchiya N, Ohtsuka
R, Ohashi J (2010) The Q223R polymorphism in LEPR is associated with obesity
in Pacific Islanders. Human Genetics 127: 287-294.
27) Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa
M, Inada T, Watanabe Y, Takahashi M, SomeyaT, Ujike H, Iwata N, Ozaki N,
Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S,Naka
I, Ohashi J, Kakita A,Takahashi H, Nawa H, Arinami T (2010) Brain Cannabinoid
CB2 Receptor in Schizophrenia. Biological psychiatry 67: 974-982.
2009
26) Naka I, Patarapotikul J, Tokunaga K, Hananantachai H, Tsuchiya N,
Ohashi J (2009) A replication study of the association between the IL12B
promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.
Malaria Journal 8: 290.
25) Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai
H, Tsuchiya N, Ohashi J (2009) Identification of a haplotype block in the
5q31 cytokine gene cluster associated with the susceptibility to severe
malaria. Malaria Journal 8:232.
24) Naka I, Patarapotikul J, Hananantachai H, Tokunaga K, Tsuchiya N, Ohashi
J (2009) IFNGR1 polymorphisms in Thai malaria patients. Infection, Genetics
and Evolution 9: 1406-1409.
2008
23) Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai
H, NAKA I, Putaporntip C, Jongwutiwes S,Tokunaga K (2008) A Functional
SNP in the CR1 Promoter Region Contributes to Protection against Cerebral
Malaria. The Journal of Infectious Diseases 198:1880-91
22) Nuchnoi P, Ohashi J, NAKA I, Nacapunchai D, Tokunaga K, Nishida N,
Patarapotikul J (2008) Linkage Disequilibrium Structure of the 5q31-33
Region in a Thai Population. Journal of Human Genetics 53: 850-856.
21) NAKA I, Ohashi J, Nuchnoi P, Hananantachai H, Looareesuwan S, Tokunaga
K ,Patarapotikul J. (2008) Lack of association of the HbE variant with
protection from cerebral malaria in Thailand. Biochemical Genetics 46(11-12):708-11.
20) Nuchnoi P, Ohashi J, Kimura R, Hananantachai H, NAKA I, Krudsood S,
Looareesuwan S, Tokunaga K, Patarapotikul J(2008) Significant association
between TIM1 promoter polymorphisms and protection against cerebral malaria
in Thailand. Annals of Human Genetics 72: 27-336.
2007
19) Ohashi J, NAKA I, Kimura R, Natsuhara K, Yamauchi T, Furusawa T, Nakazawa
N, Ataka Y, Patarapotikul J, Nuchnoi P,Tokunaga K, Ishida T, Inaoka T,
Matsumura Y, Ohtsuka R (2007) FTO polymorphisms in Oceanic populations.
Journal of Human Genetics 52: 1031-1035.
18) NAKA I, Ohashi J, Patarapotikul J, Hananantachai H, Wilairatana P,
Sornchai Looareesuwan S, Tokunaga K (2007) The genotypes of GYPA and GYPB
carrying the MNSs antigens are not associated with cerebral malaria. Journal
of Human Genetics 52: 476-479.
17) Hananantachai H, Patarapotikul J, Ohashi J, NAKA I, Krudsood S, Looareesuwan
S, Tokunaga K (2007) Significant association between TNF-α (TNF) promoter
allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand. Tissue
Antigens 69: 277-280.
2006
16) Ohashi J, NAKA I, Toyoda A, Takasu M, Tokunaga K, Ishida T, Sakaki
Y, Hohjoh H (2006) Estimation of the species-specific mutation rates of
the DRB1 locus in human and chimpanzee. Tissue Antigens 68: 427-431.
15) Ohashi J, NAKA I, Kimura R, Tokunaga K, Nakazawa M, Ataka Y, Ohtsuka
R, Inaoka T, Matsumura Y (2006) HLA-DRB1 polymorphism on Ha’ano Island
of the Kingdom of Tonga. Anthropological Science 114: 193-198.
14) Ohashi J, NAKA I, Kimura R, Tokunaga K, Yamauchi T, Natsuhara K, Furusawa
T, Yamamoto R, Nakazawa M, Ishida T,Ohtsuka R. (2006) Polymorphisms in
the ABO blood group gene in three populations in New Georgia Islands, SolomonIslands.
Journal of Human Genetics 51: 407-411.
13) Ohashi J, NAKA I, Tokunaga K, Inaoka T, Ataka Y, Nakazawa M, Matsumura
Y, Ohtsuka R. (2006) Mitochondrial DNA variation suggests extensive gene
flow from Polynesian ancestors to indigenous Melanesians in the northwestern
Bismarck archipelago. American Journal of Physical Anthropology 130: 551-556.
2005
12) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Tangpukdee N,
Looareesuwan S, Tokunaga K (2005) A functional polymorphism in the IL1B
gene promoter, IL1B -31C>T, is not associated with cerebral malaria
in Thailand. Malaria Journal 4:38.
11) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan
S, Clark AG, Tokunaga K (2005)Strong linkage disequilibrium of a HbE variant
with the (AT)9(T)5 repeat in the BP1 binding site upstream of the beta-globingene
in Thai population. Journal of Human Genetics 50: 7-11.
10) Hananantachai H, Patarapotikul J, Ohashi J, NAKA I, Looareesuwan S,
Tokunaga K (2005) Polymorphisms of HLA-B and HLA-DRB1 genes in Thai malaria
patients. Japanese Journal of Infectious Diseases 58: 25-28.
2004
9) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Brittenham G, Looareesuwan
S, Clark AG, Tokunaga K (2004) Extended linkage disequilibrium surrounding
the hemoglobin E variant due to malarial selection. American Journal of
Human Genetics 74: 1198-1208.
8) Ohashi J, NAKA I, Ohtsuka R, Inaoka T, Ataka Y, Nakazawa M, Tokunaga
K, Matsumura Y (2004) Molecular polymorphism of ABO blood group gene in
Austronesian and Non-Austronesian populations in Oceania. Tissue Antigens
63:355-361.
2003
7) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2003) A single nucleotide substitution from C to T at position
-1055 in the IL-13 promoter is associated with protection from severe malaria
in Thailand. Genes and Immunity 4: 528-531.
6) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, NAKA I, Looareesuwan
S, Tokunaga K (2003) CD36 polymorphismis associated with protection from
cerebral malaria. American Journal of Human Genetics 72: 364-374.
2002
5) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, NAKA I, Looareesuwan
S, Tokunaga K (2002) Absence of Associationbetween the Fcg receptor IIIA-176F/V
Polymorphism and the Severity of Malaria in Thai. Japanese Journal of InfectiousDiseases
55: 167-169.
4) Omi K, Ohashi J, Patarapotikul J, Hananantachai H, NAKA I, Looareesuwan
S, Tokunaga K (2002) Fcg receptor IIA and IIIB polymorphisms are associated
with susceptibility to cerebral malaria. Parasitology International 51:
361-366.
3) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2002) Significant association of longerforms of CCTTT microsatellite
repeat in inducible nitric oxide synthase (iNOS) promoter with severe malaria
in Thailand.Journal of Infectious Diseases 186: 578-581.
2001
2) Ohashi J, NAKA I, Patarapotikul J, Hananantachai H, Looareesuwan S,
Tokunaga K (2001) Absence of association between the allele coding methionine
at position 29 in the N-terminal domain of ICAM-1 (ICAM-1Kilifi) and severe
malaria in the northwest of Thailand. Japanese Journal of Infectious Diseases
54: 114-116.
1) Hananantachai H, Patarapotikul J, Looareesuwan S, Ohashi J, NAKA I,
Tokunaga K (2001) Lack of association of -308A/G TNFA promoter and 196R/M
TNFR2 polymorphisms with disease severity in Thai adult malaria patients.
American Journal of Medical Genetics 102: 391-392.
総説
中 伊津美 2014 ADRB2肥満関連多型の起源 医学のあゆみ. Vol 249, No 11, pp1217-1219
中 伊津美 2014 オセアニア集団の肥満とADRB2遺伝子多型-ゲノム人類学的視点から. 医学のあゆみ. Vol 248, No 3, pp227-229
賞
中伊津美、大橋順 (2015) 東京大学生命科学シンポジウム 優秀ポスター賞
オセアニア集団における ADRB2 遺伝子多型と肥満との関連 -肥満リスクアリルはどこから来たのか-