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Selected Publications

1. Yoshino J, Mali S, Williams CR, Morita T, Emerson C, Emerson C, Arp C, Miller S, Yin C, Hemmi C, Motoyoshi M, Ishii K, *Bautista D, *Emoto K & *Parrish JZ
Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavior outputs.
eLife (2024).

2. Furusawa K, Ishii K, Tsuji M, Tokumitsu N, Hasegawa E & *Emoto K
Presynaptic Ube3a E3 ligase promotes synapse elimination through downregulation of BMP signaling.
Science 381: 1197-1205 (2023).
DOI: 10.1126/science.ade8978

3. Tsuji M, Nishizuka Y & *Emoto K
Threat gates visual aversion via theta activity in Tachykinergic neurons.
Nature Communications 14: 3987 (2023).
DOI: 10.1038/s41467-023-39667-z

4. Nakamizo-Dojo M, Ishii K, Yoshino J, Tsuji M & *Emoto K
Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating.
Nature Communications14: 6515 (2023).
DOI: 10.1038/s41467-023-42202-9

5. Yoshino J, Morikawa R, Hasegawa E & *Emoto K
Neural circuitry that evokes escape behavior upon activation of nociceptive sensory neurons in Drosophila larvae.
Current Biology 27: 2499-2504 (2017).
DOI: 10.1016/j.cub.2017.06.068

6. Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H & *Emoto K
Adult Drosophila sensory neurons specify dendrite territories independently of dendritic contacts through the Wnt5-Drl signaling pathway.
Genes & Development 29: 1763-1775 (2015).
DOI: 10.1101/gad.262592.115

7. Kanamori T, Yoshino J, Yasunaga K, Dairyo Y & *Emoto K
Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons.
Nature Communications 6: 6515 (2015).
DOI: 10.1038/ncomms7515

8. Kanamori T, Kanai M, Dairyo Y, Yasunaga K, Morikawa R & *Emoto K
Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons.
Science 340: 1475-1478 (2013).
DOI: 10.1126/science.1234879

9. Sakurai A, Koganazawa M, Yasunaga K, Emoto K & *Yamamoto D
Select interneuron clusters determine female choosiness in Drosophila.
Nature Communications 4: 1825 (2013).
DOI: 10.1038/ncomms2837

10. Morikawa R, Kanamori T, Yasunaga K & *Emoto K
Different levels of the TRIM protein Asap regulate distinct axonal projections of Drosophila sensory neurons.
Proc Natl Acad Sci USA 108: 19389-19394 (2011).
DOI: 10.1073/pnas.1109843108

11. Yasunaga K, Kanamori T, Morikawa R, Suzuki E & *Emoto K
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase- mediated modification of the basement membranes.
Developmental Cell 18: 621-632 (2010).
DOI: 10.1016/j.devcel.2010.02.010

12. Koike-Kumagai M, Yasunaga K, Morikawa R, Kanamori T & *Emoto K
The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signaling pathway.
EMBO Journal 28: 3879-3892 (2009).
DOI: 10.1038/emboj.2009.312

13. Soba P, Zhu S, Emoto K, Younger S, Yang SJ, Yu HH, Lee T, Jan LY & *Jan YN
Drosophila sensory neurons require Dscam for dendrite self-avoidance and proper dendritic organization.
Neuron 54: 403-416 (2007).
DOI: 10.1016/j.neuron.2007.03.029

14. Parrish JZ, Emoto K, Jan LY & *Jan YN
Polycomb genes interact with the tumor suppressor hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
Genes & Development 21: 956-972 (2007).
DOI: 10.1101/gad.1514507

15. Emoto K, Parrish JZ, Jan LY & *Jan YN
The tumour suppressor Hippo acts with the NDR kinases sin dendritic tiling and maintenance.
Nature 443: 210-213 (2006).
DOI: 10.1038/nature05090

16. Emoto K, He Y, Ye B, Grueber WB, Adler PN, Jan LY & *Jan YN
Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.
Cell 119: 245-256 (2004).
DOI: 10.1016/j.cell.2004.09.036

17. Emoto K & *Umeda M
An essential role for a membrane phospholipid in cytokinesis: Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine.
J Cell Biol 149: 1215-1224 (2000).

18. Emoto K, Kuge O, Nishijima M & *Umeda M
Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine.
Proc Natl Acad Sci USA 96: 12400-12405 (1999).

19. Emoto K, Kobayashi T, Yamaji A, Aizawa H, Yahara I, Inoue K & *Umeda M
Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis.
Proc Natl Acad Sci USA 93: 12867-12872 (1996).

2023

        1. Furusawa K, Ishii K, Tsuji M, Tokumitsu N, Hasegawa E & *Emoto K

Presynaptic UBE3A E3 ligase promotes synapse elimination by downregulation of BMP signaling.

Science 381: 1197-1205 (2023).

Press Release

 

    1. Tsuji M, Nishizuka Y & *Emoto K

Threats gate visual aversion via theta activity in Tachykinergic neurons

Nature Communications 14: 3987 (2023).

Press Release

 

    1. Nakamizo-Dojo M, Ishii K, Yoshino J, Tsuji M & *Emoto K

Descending GABAergic system links brain sugar-sensing and peripheral nociceptive gating.

Nature Communications (2023).

 

    1. Yoshino J, Mali S, Williams CR, Morita T, Emerson C, Arp C, Miller S, Yin C, Motoyoshi M, Hemmi C, Ishii K, *Bautista D, *Emoto K & *Parrish JZ

Drosophila epidermal cells are intrinsically mechanosensitive and drive nociceptive behavior outputs.

eLife (2023)

 

    1. Tekeuchi S, Shimizu K, Futada Y & *Emoto K

    The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity.

    Communications Biology 6: 332 (2023).

    Press Release

     

      1. Maejima I, Hara T, Tsukamoto S, Koizumi H, Kawauchi T, Akuzawa T, Hirai R, Kobayashi H, Isobe I, Kosako H, Emoto K & Sato K

      Rab35 is required for hippocampal development and functions by regulating by neuronal cell distribution.

      Communications Biology 6: 440 (2023).

       

        1. Lu M.H., Uematsu A, Kiyokawa Y, Emoto K & Takeuchi Y

        The posterior complex of the anterior olfactory nucleus sends glutamatergic predominant projections to the basolateral complex of the amygdala and posteroventral part of the medial amygdala.

        Neuroscience 521: 102-109 (2023).

         

          1. Inagaki S, Morimoto Y, Suzuki IK, Emoto K & Takeuchi S

          Co-culture system of human skin equivalents with neural spheroids

          J Biosci Bioeng (2023).

          2022

            1. Kenichi Ishii, Matteo Cortese, Xubo Leng, Maxim N Shokhirev, Kenta Asahina

          A neurogenetic mechanism of experience-dependent suppression of aggression.

          Science Advances 8(36) eabg3203 (2022).
           

            1. Ryota Nakahama, Aika Saito, Sensho Nobe, Kazuya Togashi, Ikuo K. Suzuki, Akira Uematsu & Emoto K

          The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency.

          Molecular Brain 15: Article number: 70 (2022).
           

            1. Ikuo K. Suzuki

          Evolutionary innovations of human cerebral cortex viewed through the lens of high‐throughput sequencing.

          Developmental Neurobiology 82: 476-494 (2022).
           

          2021

            1. Bergoglio E, Suzuki IK, Tsuji M, Togashi K, Takeuchi S, Koizumi H & Emoto K

          Spatial and temporal diversity of DCLK1 isoforms in the developing mouse cortex.

          Neuroscience Research 170: 154-165 (2021).
           

            1. Furusawa K & Emoto K

          Spatiotemporal control of developmental neurite pruning: Molecular and cellular insights from Drosophila models.

          Neuroscience Research 167: 54-63 (Invited Review) (2021).
           

            1. Furusawa K & Emoto K

          Scrap and build for functional neural circuits: Spatiotemporal regulation of dendrite degeneration and regeneration in development and disease.

          Frontiers in Cellular Neuroscience 14: 613320 (Invited Review) (2021).
           

          2020

          1. Omamiuda-Ishikawa N, Sakai M & Emoto K

          A pair of ascending neurons in the subesophageal zone mediates aversive sensory inputs-evoked backward locomotion in Drosophila larvae.
          PLoS Genetics 16: e1009120 (2020).
           

          1. Kitatani Y, Tezuka A, Hasegawa E, Yagagi S, Togashi K, Tsuji M, Kondo S, Parrish JZ & Emoto K

          Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.
          PLoS Genetics 16: e1008942 (2020).
           

          1. Togashi K, Tsuji M, Takeuchi S, Nakahama R, Koizumi H & Emoto K

          Adeno associated virus-mediated single cell labeling of mitral cells in the mouse olfactory bulb: Insights into the developmental dynamics of dendrite remodeling.
          Frontiers in Cellular Neuroscience 14: 572256 (2020).
           

          1. Yoshino J, Emoto K & Parrish JZ

          Think globally, act locally: Scaling the growth of motor neurons.
          Developmental Cell 54: 5-6 (Invited Review) (2020).
           

          1. 竹内俊佑・冨樫和也・榎本和生

          嗅覚神経回路の発達リモデリング
          Clinical Neuroscience 「特集：脳の発生とその異常」38: 1534-1538 (2020).
           

          2019

          1. 中浜涼太・増岡宏哉・長谷川恵理・冨樫和也・榎本和生

          神経回路の除去と再生の分子細胞基盤
          生体の科学「特集：脳神経回路のダイナミクスから探る脳発達・疾患・老化」70: 14-18 (2019).
           

          1. 辻真人・中溝真未・榎本和生

          内的状態による行動選択の制御
          生体の科学「特集：脳神経回路のダイナミクスから探る脳発達・疾患・老化」70: 48-52 (2019).
           

          2018

          1. Nao Utashiro, Claire Williams, Jay Parrish, Kazuo Emoto

          Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior.
          Scientific Reports ; 8: 8580
           

          1. 長谷川恵理・北谷育子・柳学理・榎本和生

          「神経突起の選択的除去メカニズム」特集：スクラップ＆ビルドで発達する脳神経回路と高次脳機能
          実験医学36号: 1978-1986 (2018).
           

          1. 竹内俊祐・藤島航大・奥山圭・冨樫和也・榎本和生

          「嗅覚回路から神経回路再編メカニズムを解き明かす」特集：スクラップ＆ビルドで発達する脳神経回路と高次脳機能
          実験医学36号: 2024-2029 (2018).

          2017

          1. Yoshino J, Morikawa R, Hasegawa E and Emoto K.

          Neural circuitry that evokes escape behavior in response to nociceptive stimuli in Drosophila larvae.
          Curr Biol 27: 2499-2504 (2017).

          1. Koizumi H, Fujioka H, Togashi K, Thompson J, Yates JR, 3rd, Gleeson JG, and Emoto K.

          DCLK1 phosphorylates the microtubule-associated protein MAP7D1 to promote axon elongation in cortical neurons
          Developmental Neurobiology Apr;77(4):493-510 (2017).

          2016

          1. Togashi K, Koizumi H, Kanamori T and Emoto K

          Molecular control of dendrite remodeling.
          Dendrites: Development and Disease

          2015

          1. Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H and Emoto K

          Adult Drosophila sensory neurons specify dendrite boundaries independently of dendritic contacts through the Wnt5-Drl signaling pathway.
          Genes Dev 29: 1763-1775 (2015).

          1. Kanamori T, Togashi K, Koizumi H and Emoto K

          Dendrite pruning: lessons from invertebrate model systems.
          Int Rev Cell Mol Biol (Invited Review) 318: 1-25 (2015).

          1. Kanamori, T., Yoshino, J., Yasunaga, K., Dairyo, Y., and Emoto, K.

          Local endocytosis triggers dendrite thinning and pruning in Drosophila sensory neurons.
          Nature Communications 6: 6515 (2015).

          2014

          1. Yang, L., Li, R., Kaneko, T., Takle, K., Morikawa, K.R., Essex, L., Wang, X., Zhou, J., Xing, Y., Emoto, K., and Ye, B.K

          Trim9 regulates activity-dependent fine-scale topography in Drosophila.
          Curr. Biol. 24: 1024-1030 (2014).

          2013

          1. Kanamori, T., Kanai, M., Dairyo, Y., Yasunaga, K., Morikawa, R., and Emoto, K.

          Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons.
          Science 340: 1475-1478 (2013).

          1. Sakurai, A., Koganazawa, M., Yasunaga, K., Emoto, K., and Yamamoto, D.

          Select interneuron clusters determine female choosiness in Drosophila.
          Nature Communications 4: 1825 (2013).

          1. Kato, U., Inadome, H., Yamamoto, M., Emoto, K., Kobayashi, T., and Umeda, M.

          A phospholipid flippase complex of Type IV P-type ATPase ATP8A1 and CDC50A is required for cell migration.
          J. Biol. Chem. 288: 4922-4934 (2013).

          2012

          1. Emoto, K.

          Signaling mechanisms that coordinate the development and maintenance of dendritic fields.
          Curr. Opin. Neurobiol. (Invited Review) 22: 805-811 (2012).

          1. Eneling, K., Brion, L., Pinto, V., Pinho, M. J., Mochizuki, N., Emoto, K., Soares-da-Silva, P., and Bertorello, A. M.

          Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability.
          FASEB J. 26:3230-3239 (2012).

          1. Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T., and Arai, H.

          Impaired retrograde membrane traffic in a mutant CHO cell defective in phosphatidylserine synthesis.
          Genes Cells 17:728-736 (2012).

          2011

          1. Morikawa R., Kanamori, T., Yasunaga, K., and Emoto, K.

          Different levels of the TRIM protein Asap regulate distinct axonal projections of Drosophila sensory neurons.
          Proc. Natl. Acad. Sci. USA 108: 19389-19394 (2011).

          1. Yasunaga, K and Emoto, K..

          Matrix metalloproteinases in neuronal plasticity and disease.
          Matrix Metalloproteinases: Biology, Functions and Clinical Implications. (Invited Review) NOVA Bioscience Press (2011).

          1. Emoto, K.

          The growing role of the Hippo-NDR kinase signaling in neuronal development and disease.
          J. Biochem. (Invited Review) 150: 133-141 (2011).

          1. Emoto, K.

          Dendrite remodeling in development and disease.
          Dev. Growth Differ. (Invited Review) 53: 277-286 (2011).

          2010

          1. Yasunaga, K., Kanamori T., Morikawa, R., Suzuki, E., and Emoto, K.

          Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase- mediated modification of the basement membranes.
          Dev. Cell 18: 621-632 (2010).

          1. Fang, X., Lu, Q., Emoto, K., and Adler, P. N.

          The Drosophila Furry protein interacts with Trc and is highly mobile in vivo.
          BMC Dev. Biol. 10: 40 (2010).

          2009

          1. Koike-Kumagai, M., Yasunaga, K., Morikawa, R., Kanamori T., and Emoto, K.

          The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signaling pathway.
          EMBO J. 28: 3879-3892 (2009).

          2007

          1. Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S.J., Yu, H.H., Lee, T., Jan, L.Y., and Jan, Y.N.

          Drosophila sensory neurons require Dscam for dendrite self-avoidance and proper dendritic organization.
          Neuron 54: 403-416 (2007).

          1. Parrish, J. Z., Emoto, K., Jan, L., and Jan, Y. N.

          Polycomb genes interact with the tumor suppressor hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
          Genes Dev. 21: 956-972 (2007).

          1. Parrish, J. Z.*, Emoto, K.*, Kim, M. D., and Jan, Y. N.

          Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. (*equal contribution).
          Annu. Rev. Neurosci. 30: 399-423 (2007).

          2006

          1. Emoto, K., Parrish, J. Z., Jan, L., and Jan, Y. N.

          The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.
          Nature 443: 210-213 (2006).

          2005

          1. Emoto, K., Inadome, H., Kanaho, Y., Narumiya, S., and Umeda, M.

          Local change of phospholipid composition at the cleavage furrow is essential for completion of cytokinesis.
          J. Biol. Chem. 280: 37901-37907 (2005).

          1. He, Y., Emoto, K., Fang, X., Ren, N., Tian, X., Jan, Y. N., and Adler, P. N.

          Drosophila Mob family proteins interact with the related Tricornered (Trc) and Warts (Wts) Kinases.

          Mol. Biol. Cell 16: 4139-4152 (2005).

          1. Waldhuber, M., Emoto, K., and Petrisch, C.

          The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals.
          Mech. Dev. 122: 914-927 (2005).

          1. He, Y., Fang, X., Emoto, K., Jan, Y. N., and Adler, P. N.

          The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development.
          Mol. Biol. Cell 16: 689-700 (2005).

          2004

          1. Emoto, K., He, Y., Ye, B., Grueber, W. B., Adler, P. N., Jan, L. Y., and Jan, Y. N.

          Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.
          Cell 119: 245-256 (2004).

          1. Ichimura, Y., Imamura, Y., Emoto, K., Umeda, M., Noda, T., and Ohsumi, Y.

          In vivo and in vitro reconstitution of atg8 conjugation essential for autophagy.
          J. Biol. Chem. 279: 40584-40592 (2004).

          2003

          1. Kametaka, S., Shibata, M., Moroe, K., Kanamori, S., Ohsawa, Y., Waguri, S., Sims, P. J., Emoto, K., Umeda, M., and Uchiyama, Y.

          Identification of phospholipid scramblase 1 as a novel interacting molecule with β-secretase (BACE).
          J. Biol. Chem. 278: 15239-15245 (2003).

          2002

          1. Kato, U., Emoto, K., Fredriksson, C., Nakamura, H., Ohta, A., Kobayashi, T., Murakami-Murobushi, K., Kobayashi, T., and Umeda, M.

          Ros3p, a novel membrane protein, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae.
          J. Biol. Chem. 277: 37855-37862 (2002).

          1. Emoto, K., and Umeda, M.

          Membrane lipid control of cytokinesis.
          Cell Struct. Funct. (Invited Review) 26: 569-575 (2002).

          1. Emoto, K., and Umeda, M.

          Apoptosis by phosphatidylserine in mammalian cells. Phospholipid metabolism in apoptosis. (edited by Quinn, P.J.& Kagan, V.)
          Subcell. Biochem. (Invited Review) 36: 61-71 (2002) Plenum Press. New York.

          2001

          1. Imai, H., Suzuki, K., Ishizaka, K., Oshima, H., Ichinose, S., Okayasu, I., Emoto, K., Umeda, M., and Nakagawa, Y.

          Failure of the expression of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in the spermatozoa of infertile males.
          Biol. Reprod. 64: 674-683 (2001).

          1. Umeda, M., Emoto, K., and Kato, U.

          Regulation of actin filament organization by transbilayer redistribution of membrane phospholipids.
          Proc. Int. Sympo. Adv. Phys. Fields 7: 131-134 (2001).

          ～2000

          1. Emoto, K., and Umeda, M.

          An essential role for a membrane phospholipid in cytokinesis: Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine.
          J. Cell Biol. 149: 1215-1224 (2000).

          1. Emoto, K., Kuge, O., Nishijima, M., and Umeda, M.

          Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine.
          Proc. Natl. Acad. Sci. USA 96: 12400-12405 (1999).

          1. Arai, M., Imai, H., Koumura, T., Yoshida, M., Emoto, K., Umeda, M., Chiba, N., and Nakagawa, Y.

          Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells.
          J. Biol. Chem. 274: 4924-4933 (1999).

          1. Ikemoto, A., Kobayashi, T., Emoto, K., Umeda, M., Watanabe, S., and Okuyama, H.

          Effects of docosahexaenoic and arachidonic acids on the synthesis and distribution of aminophospholipids during neuronal differentiation of PC 12 cells.
          Arch. Biochem. Biophys. 364: 67-74 (1999).

          1. Umeda, M., and Emoto, K.

          Membrane phospholipid dynamics during cytokinesis: regulation of actin filament assembly by redistribution of membrane surface phospholipid.
          Chem. Phys. Lipids (Invited Review) 101: 81-91 (1999).

          1. Uchida, K., Emoto, K., Daleke, D. L., Inoue, K., and Umeda, M.

          Induction of apoptosis by phosphatidylserine.
          J. Biochem. 123: 1073-1078 (1998).

          1. Yamaji, A., Sekizawa, Y., Emoto, K., Sakuraba, H., Inoue, K., Kobayashi, H., and Umeda, M

          Lysenin, a novel sphingomyelin-specific binding protein.
          J. Biol. Chem. 273: 5300-5306 (1998).

          1. Emoto, K., Toyama-Sorimachi, N., Karasuyama, H., Inoue, K., and Umeda, M.

          Exposure of phosphatidylethanolamine on the surface of apoptotic cells.
          Exp. Cell Res. 232: 430-434 (1997).

          1. Emoto, K., Kobayashi, T., Yamaji, A., Aizawa, H., Yahara, I., Inoue, K., and Umeda, M.

          Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis.
          Proc. Natl. Acad. Sci. USA 93: 12867-12872 (1996).