Research Highlights

	Key protein regulates immune response to viruses in mammal cells ・Kumiko Ui-Tei ・Tomoko Takahashi ・Mitsutoshi Yoneyama [Press Release]Apr 19, 2024 Nucleic Acids Research.
	Discovery of a skull of the Jomon period stabbed destructively: A new material for exploring the nature of violence in the Jomon period ・Rikiya Hirano ・Yosuke Kaifu [Press Release]Apr 04, 2024 Anthropological Science (Japanese Series).
	Tiny orchid flowers pollinated by tiny flies ・Yuta SUNAKAWA ・Ko MOCHIZUKI ・Atsushi KAWAKITA [Press Release]Mar 30, 2024 Ecology.
	Sap beetles vs wind: what pollinates screw pines? ・Toru MIYAMOTO ・Ko MOCHIZUKI ・Atsushi KAWAKITA [Press Release]Mar 28, 2024 Botanical Journal of the Linnean Society.
	“Noisy” roundworm brains give rise to individuality ・Yu Toyoshima ・Hirofumi Sato ・Daiki Nagata ・Manami Kanamori ・Moon Sun Jang ・Koyo Kuze ・Suzu Oe ・Takayuki Teramoto ・Yuishi Iwasaki ・Ryo Yoshida ・Takeshi Ishihara ・Yuichi Iino [Press Release]Mar 16, 2024 PLoS Computational Biology.
	Obesity disrupts normal liver function in mice: Comparison of mice at feeding and fasting shows biological regulation is reversed due to obesity ・Shinya Kuroda ・Yunfan Bai ・Keigo Morita [Press Release]Feb 27, 2024 iScience.
	Structure of the active form of the LysoPS receptor involved in immune responses: contributing to drug discovery research by elucidating the binding mode of agonists ・Tamaki Izume ・Ryo Kawahara ・Wataru Shihoya ・Osamu Nureki ・Akiharu Uwamizu ・Luying Chen ・Tomohiko Ohwada ・Junken Aoki [Press Release]Feb 07, 2024 Nature Communications.
	Follow the salt: connecting salt concentrations and motion in roundworms ・Ayaka Matsumoto ・Yu Toyoshima ・Chenqi Zhang ・Akihiro Isozaki ・Keisuke Goda ・Yuichi Iino [Press Release]Jan 23, 2024 PNAS.
	Regulating voltage-gated ion channels ・Daichi Yamanouchi ・Go Kasuya ・Koichi Nakajo ・Yoshiaki Kise ・Osamu Nureki [Press Release]Nov 30, 2023 Molecular Cell.
	This sea worm’s butt swims away, and now scientists know how. ・Mayuko Nakamura ・Daisuke S. Sato ・Sumika Kato ・Kohei Oguchi ・Masanori Okanishi ・Yoshinobu Hayashi ・M. Teresa Aguado ・Toru Miura [Press Release]Nov 22, 2023 Scientific Reports.
	Developed a technique to measure the behavior of root-growing cells and clearly present changes in their behavior ・Keiji Nakajima ・Tatsuaki Goh ・Yen-Wei Chen ・Masahiko Inami ・Takaaki Yonekura ・Yohei Kondo ・Yutaro Iwamoto [Press Release]Oct 20, 2023 Plant and Cell Physiology.
	How do plants adapt to changing environments? ・Shusei Mori ・Soichi Inagaki ・Tetsuji Kakutani [Press Release]Oct 20, 2023 EMBO Journal.
	Elucidating How Eating Sugar Suppresses Pain Response ・Mami Nakamizo-Dojo ・Kenichi Ishii ・Jiro Yoshino ・Masato Tsuji ・Kazuo Emoto [Press Release]Oct 18, 2023 Nature Communications.
	Small but mighty new gene editor ・Satoshi N. Omura ・Ryoya Nakagawa ・Osamu Nureki ・Tomohiro Hino ・Atsushi Hoshino ・Satoaki Matoba ・Tomoki Togashi ・Tsukasa Ohmori [Press Release]Sep 30, 2023 Cell.
	Fish reveal cause of altered human facial development ・Shujie Liu ・Toru Kawanishi ・Atsuko Shimada ・Naohiro Ikeda ・Masayuki Yamane ・Hiroyuki Takeda ・Junichi Tasaki [Press Release]Sep 28, 2023 Toxicological Sciences.
	Insects switch the form and function of their gut symbionts and their habitats through ・Minoru Moriyama ・Ryo Futahashi ・Sayumi Oishi ・Masaki Mizutani ・Takema Fukatsu [Press Release]Sep 26, 2023 PNAS.
	How a molecule deletes neural chat might help treat Angelman syndrome ・Kotaro Furusawa ・Kenichi Ishii ・Masato Tsuji ・Nagomi Tokumitsu ・Eri Hasegawa ・Kazuo Emoto [Press Release]Sep 15, 2023 Science.
	Killing cancer cells ・Hiroshi Ebata ・Tomohiro Shima ・Ryo Iizuka ・Sotaro Uemura [Press Release]Sep 04, 2023 FEBS Open Bio.
	Fungus gnats as pollinators not pests: Dipteran insect identified as having a key role in driving floral diversity of Euonymus plant ・Ko Mochizuki ・Atsushi Kawakita [Press Release]Aug 24, 2023 Annals of Botany.
	What explains the diverse breathing pores in plants? ・Yuki Doll ・Hiroyuki Koga ・Hirokazu Tsukaya [Press Release]Aug 09, 2023 Journal of Experimental Botany.
	Deep learning helps identify cell types based on their gene expression ・Shangru Jia ・Tatsuhiko Tsunoda ・Artem Lysenko ・Alok Sharma ・Keith A Boroevich [Press Release]Aug 01, 2023 Briefings in Bioinformatics.
	What’s in a fish brain? Clues for the evolution of our brain ・Ryohei Nakamura ・Yasuko Isoe [Press Release]Jul 25, 2023 eLife.
	Fear is in the eye of the beholder: A cluster of neurons in the brains of fruit flies has been found to control visual aversion to scary objects ・Masato Tsuji ・Yuto Nishizuka ・Kazuo Emoto [Press Release]Jul 13, 2023 Nature Communications.
	Sex chromosomes reveal how three sexes can co-exist in these algae ・Kohei Takahashi ・Tetsuya Higashiyama ・Hisayoshi Nozaki [Press Release]Jun 09, 2023 Communications Biology.
	A new way to develop drugs without side effects ・Kazuhiro Kobayashi ・Kouki Kawakami ・Tsukasa Kusakizako ・Asuka Inoue ・Takeshi Murata ・Osamu Nureki [Press Release]Jun 08, 2023 Nature.
	The evolution of honey bee brains: Specialized neurons in some insect brains, related to highly evolved behaviors, may have developed from a multifunctional ancestor ・Takayoshi Kuwabara ・Hiroki Kohno ・Masatsugu Hatakeyama ・Takeo Kubo [Press Release]May 08, 2023 Science Advances.
	LincRNA paints a target on diseased tissues ・Yu Hamba ・Tatsuhiko Thunoda [Press Release]Apr 27, 2023 iScience Apr 26.
	The structure of the ETB-Gi complex revealed: a step towardenhanced anti-cancer drugs ・Fumiya K Sano ・Hiroaki Akasaka ・Wataru Shihoya ・Osamu Nureki [Press Release]Apr 25, 2023 eLife Apr 25.
	These protein lumps might help regulate gene expression ・Haruka Narita ・Tomohiro Shima ・Ryo Iizuka ・Sotaro Uemura [Press Release]Apr 19, 2023 BMC Biology Apr 19.
	How does a millipede get its legs? New legs on millipede Niponia nodulosa appear before, rather than only after, molting ・Soma Chiyoda ・Kohei Oguchi ・Toru Miura [Press Release]Apr 20, 2023 Frontiers in Zoology Apr 18
	New details of Tully monster revealed: 3D scanning of enigmatic fossil may have brought an end to debate about whether it is a vertebrate or invertebrate ・Tomoyuki Mikami ・Takafumi Ikeda ・Yusuke Muramiya ・Tatsuya Hirasawa ・Wataru Iwasaki [Press Release]Apr 17, 2023 Palaeontology Apr 16.
	HD-ZIP III-dependent local promotion of brassinosteroid synthesis suppresses vascular cell division in Arabidopsis root apical meristem ・Kyoko Ohashi-Ito ・Kuninori Iwamoto ・Ayumi Yamagami ・Takeshi Nakano ・Hiroo Fukuda [Press Release]Apr 12, 2023 PNAS Apr 3.
	Study reveals the 3D structure of a protein involved in genome editing ・Ryoya Nakagawa ・Hisato Hirano ・Satoshi N. Omura ・Osamu Nureki [Press Release]Apr 06, 2023 Nature Apr 05.
	The circadian clock in the mouse piriform cortex plays an intrinsic role in daily changes in odor-evoked neural activity ・Shunsuke Takeuchi ・Kimiko Shimizu ・Yoshitaka Fukuda ・Kazuo Emoto [Press Release] Apr 05, 2023 Communications Biology Mar 27.
	Like a flexible Lego railway track: how stable microtubules form within cells ・Hanjin Liu ・Tomohiro Shima [Press Release] Mar 09, 2023 Life Science Alliance Mar 09.
	Structural basis for clearing of ribosome collisions by the RQT complex ・Toshifumi Inada ・Yoshitaka Matsuo ・Katharina Best ・Roland Beckmann [Press Release] Mar 07, 2023 Nature Communications Feb 17.
	Uncovering the traits of Japan’s dual ancestryNew research reveals historical regional mix and genetic predispositions to obesity and asthma ・Yusuke Watanabe ・Jun Ohashi [Press Release] Feb 21, 2023 Molecular cell Feb 03.
	Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control ・Shuhei Ebine ・Toshihumi Inada ・Petr Tesina ・Roland Beckmann [Press Release] Feb 17, 2023 Molecular cell Feb 16.
	Machine learning predicts bacterial genome evolution ・Naoki Konno ・Wataru Iwasaki [Press Release] Jan 12, 2023 Science Advances Jan 11.
	Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay ・Shota Tomomatsu ・Toshifumi Inada [Press Release] Jan 6, 2023 Nucleic Acids Research Dec 30.
	Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex ・Yoshitaka Matsuo ・Toshifumi Inada ・Takayuki Uchihashi [Press Release] Jan 10, 2023 Nature Communications Jan 10.
	Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover ・Toshifumi Inada ・Sihan Li ・Roland Beckmann [Press Release] Sep 16, 2022 Molecular Cell Sep 15.
	A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation ・Toshifumi Inada ・Momoko Narita ・Roland Beckmann [Press Release] Nov 04, 2022 Nature Communications Oct 27.
	Massive marimo algae balls at risk from deadly winter sunburn ・Akina Obara ・Mari Ogawa ・Yoichi Oyama ・Yoshihiro Suzuki ・Masaru Kono [Press Release] Dec 23, 2022 International Journal of Molecular Sciences Dec 23.
	Cells rearrange to shape a tissue during development ・Keisuke Ikawa ・Shuji Ishihara ・Yoichiro Tamori ・Kaoru Sugimura [Press Release]Dec 21, 2022 Current Biology Dec 20.
	Is it a leaf or is it a petal? ・Ayaka Kinoshita ・Makiko Naito ・Zining Wang ・Yasuhiro Inoue ・Atsushi Mochizuki ・Hirokazu Tsukaya [Press Release]Dec 12, 2022 Development Dec 12.
	Flowers show their true colorsA common flower with a unique bidirectional color-changing ability ・Yukiko Furukawa ・Nobumitsu Kawakubo ・Hirokazu Tsukaya [Press Release]Dec 01, 2022 Scientific Reports Dec 01.
	Mother’s cells acquired by babies may help regulate their immune system ・Flore S. Castellan ・Naoki Irie [Press Release]Nov 9, 2022 Biology Open Nov 9.
	Neuropeptide important for testicular morphogenesis and functions in medaka ・Soma Tomihara ・Kana Ikegami ・Rinko Shimomai ・Chie Umatani [Press Release]Nov 8, 2022 PNAS Nov 8.
	Clarification of overall maternal cell types in fetus and their inter-individual differences ・Kana Fujimoto ・Yumiko Tanaka ・Sotaro Uemura ・Naoki Irie [Press Release]Nov 4, 2022 Scientific Reports Nov 4.
	Developmental process of "lungs" in terrestrial isopods colonized ・Naoto Inui ・Ryosuke Kimbara ・Haruka Yamaguchi ・Toru Miura [Press Release]Oct 6, 2022 Arthropod Structure & Development Oct 4.
	Unravelling a novel mechanism underlying CO2-induced stomatal closure ・Eigo Ando ・Toshinori Kinoshita ・Ichiro Terashima [Press Release]Oct 2, 2022 New Phytologist Sep 11.
	Aggression de-escalation gene identified in fruit flies ・Kenichi Ishii ・Kenta Asahina [Press Release]Sep 8, 2022 Science Advances Sep 7.
	Stress-dependent cell-stiffening by tardigrade tolerance proteins ・Akihiro Tanaka ・Tomomi Nakano ・Masaaki Oyama ・Miho Yanagisawa ・Takekazu Kunieda [Press Release]September 7, 2022 PLOS Biol. Sep 6.
	Mechanism and biological significance of rhythmic transcription of clock gene Bmal1 ・Yasuko O. Abe ・Hikari Yoshitane ・Yoshitaka Fukada [Press Release (in Japanese)]2022/08/23 Nature Commun. Aug 23.
	Record and decode: Two ways of distributing histone modification in genomes ・Satoyo Oya ・Tetsuji Kakutani ・Soichi Inagaki [Press Release (in Japanese)]2022/08/11 Nature Commun. Aug 11.
	Endogenous ligand recognition and structural transition of a human PTH receptor ・Kazuhiro Kobayashi ・Kouki Kawakami ・Tsukasa Kusakizako ・Hideaki E. Kato ・Asuka Inoue ・Osamu Nureki [Press Release (in Japanese)]2022/08/09 Mol Cell. Aug 4.
	Ten new ribbon worms in the genus Nipponnemertes discovered from Northwestern Pacific ・Natsumi Hookabe ・Hiroshi Kajihara ・Naoto Jimi ・Alexei V. Chernyshev ・Rei Ueshima [Press Release (in Japanese)]2022/07/26 Front. Mar. Sci. Jul 26.
	Image-based parameter inference for epithelial mechanics ・Goshi Ogita ・Takefumi Kondo ・Keisuke Ikawa ・Tadashi Uemura ・Shuji Ishihara ・Kaoru Sugimura [Press Release (in Japanese)]2022/06/24 PLOS Comput. Biol. Jun 23.
	Autophagy contributes sperm differentiation in plants ・Takuya Norizuki ・Naoki Minamino ・Miyuki Sato ・Hirokazu Tsukaya ・Takashi Ueda [Press Release (in Japanese)]2022/06/15 Cell Rep. Jun 14.
	The Whole Picture of C. elegans Memory: The Protein Responsible for Salt concentration Memory and The Novel Mechanism for Reading it out ・Shingo Hiroki ・Yuichi Iino [Press Release (in Japanese)]2022/06/01 Nature Commun. May 27
	Limitation of anatomical diversification by developmental unchangeability ・Yui Uchida ・Shuji Shigenobu ・Hiroyuki Takeda ・Chikara Furusawa ・Naoki Irie [Press Release (in Japanese)]2022/04/11 BMC biol. Apr 11.
	Molecular mechanisms underlying metamorphosis in the most ancestral winged insect ・Genta Okude ・Takema Fukatsu ・Ryo Futahashi [Press Release (in Japanese)]2022/02/22 PNAS. 2022 Mar 1.
	Mechanisms to generate inactive domains within the plant genome ・Tetsuji Kakutani ・Taiko Kim To [Press Release (in Japanese)]2022/02/14 Nat Commun. 2022 Feb 14.
	Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism ・Saori Uematsu ・Satoshi Ohno ・Shinya Kuroda [Press Release (in Japanese)]2022/02/05 iScience 2022 Feb 3.
	Neural mechanisms of regular ovulatory cycle in female medaka ・Kana Ikegami ・Chie Umatan ・Yoshitaka Oka [Press Release (in Japanese)]2022/2/4 J Neuroendocrinol. 2022 Feb 3.
	A new species of branching annelid from Sado Island ・Mayuko Nakamura ・Kohei Oguchi ・Akihito Omori ・Hisanori Kohtsuka ・Yuji Ise ・Naoto Jimi ・Toru Miura [Press Release (in Japanese)]2022/1/20 Org Divers Evol. 2022 Jan 19.
	Termite genome analysis highlights the significant role of gene duplication in social evolution ・Toru Miura [Press Release (in Japanese)]2022/1/19 PNAS. 2022 Jan 18.
	Neural mechanisms that modulate the motivation for male sexual behaviors ― neuromodulation by co-existing two neuropeptides in the same neuron ― ・Chie Umatani ・Yoshitaka Oka [Press Release (in Japanese)]2022/1/14 Endocrinology 2022 Feb.
	Reconstruction of extremely large lineage trees by FRACTAL ・Naoki Konno ・Wataru Iwasaki ・Nozomu Yachie [Press Release (in Japanese)]2022/1/7 Nat Biotechnol. 2022 Jan 06.
	The function of learning regulating protein is supported by back-up systems using the closely related protein ・Shingo Hiroki ・Yuichi Iino [Press Release (in Japanese)]2021/12/28 PNAS. 2022 Jan 18.

Here, the latest research results that made the press release from the University of Tokyo are posted in 2017. In addition to these results, many other research results have been published at all times from the Department of Biological Sciences. Please refer to each lab web page for the latest publications.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo

Research Highlights

Key protein regulates immune response to viruses in mammal cells

Discovery of a skull of the Jomon period stabbed destructively: A new material for exploring the nature of violence in the Jomon period

Tiny orchid flowers pollinated by tiny flies

Sap beetles vs wind: what pollinates screw pines?

“Noisy” roundworm brains give rise to individuality

Obesity disrupts normal liver function in mice: Comparison of mice at feeding and fasting shows biological regulation is reversed due to obesity

Structure of the active form of the LysoPS receptor involved in immune responses: contributing to drug discovery research by elucidating the binding mode of agonists

Follow the salt: connecting salt concentrations and motion in roundworms

Regulating voltage-gated ion channels

This sea worm’s butt swims away, and now scientists know how.

Developed a technique to measure the behavior of root-growing cells and clearly present changes in their behavior

How do plants adapt to changing environments?

Elucidating How Eating Sugar Suppresses Pain Response

Small but mighty new gene editor

Fish reveal cause of altered human facial development

Insects switch the form and function of their gut symbionts and their habitats through

How a molecule deletes neural chat might help treat Angelman syndrome

Killing cancer cells

Fungus gnats as pollinators not pests: Dipteran insect identified as having a key role in driving floral diversity of Euonymus plant

What explains the diverse breathing pores in plants?

Deep learning helps identify cell types based on their gene expression

What’s in a fish brain? Clues for the evolution of our brain

Fear is in the eye of the beholder: A cluster of neurons in the brains of fruit flies has been found to control visual aversion to scary objects

Sex chromosomes reveal how three sexes can co-exist in these algae

A new way to develop drugs without side effects

The evolution of honey bee brains: Specialized neurons in some insect brains, related to highly evolved behaviors, may have developed from a multifunctional ancestor

LincRNA paints a target on diseased tissues

The structure of the ETB-Gi complex revealed: a step towardenhanced anti-cancer drugs

These protein lumps might help regulate gene expression

How does a millipede get its legs? New legs on millipede Niponia nodulosa appear before, rather than only after, molting

New details of Tully monster revealed: 3D scanning of enigmatic fossil may have brought an end to debate about whether it is a vertebrate or invertebrate

HD-ZIP III-dependent local promotion of brassinosteroid synthesis suppresses vascular cell division in Arabidopsis root apical meristem

Study reveals the 3D structure of a protein involved in genome editing

The circadian clock in the mouse piriform cortex plays an intrinsic role in daily changes in odor-evoked neural activity

Like a flexible Lego railway track: how stable microtubules form within cells

Structural basis for clearing of ribosome collisions by the RQT complex

Uncovering the traits of Japan’s dual ancestryNew research reveals historical regional mix and genetic predispositions to obesity and asthma

Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control

Machine learning predicts bacterial genome evolution

Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay

Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex

Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation

Massive marimo algae balls at risk from deadly winter sunburn

Cells rearrange to shape a tissue during development

Is it a leaf or is it a petal?

Flowers show their true colorsA common flower with a unique bidirectional color-changing ability

Mother’s cells acquired by babies may help regulate their immune system

Neuropeptide important for testicular morphogenesis and functions in medaka

Clarification of overall maternal cell types in fetus and their inter-individual differences

Developmental process of "lungs" in terrestrial isopods colonized

Unravelling a novel mechanism underlying CO2-induced stomatal closure

Aggression de-escalation gene identified in fruit flies

Stress-dependent cell-stiffening by tardigrade tolerance proteins

Mechanism and biological significance of rhythmic transcription of clock gene Bmal1

Record and decode: Two ways of distributing histone modification in genomes

Endogenous ligand recognition and structural transition of a human PTH receptor

Ten new ribbon worms in the genus Nipponnemertes discovered from Northwestern Pacific

Image-based parameter inference for epithelial mechanics

Autophagy contributes sperm differentiation in plants

The Whole Picture of C. elegans Memory: The Protein Responsible for Salt concentration Memory and The Novel Mechanism for Reading it out

Limitation of anatomical diversification by developmental unchangeability

Molecular mechanisms underlying metamorphosis in the most ancestral winged insect

Mechanisms to generate inactive domains within the plant genome

Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism

Neural mechanisms of regular ovulatory cycle in female medaka

A new species of branching annelid from Sado Island

Termite genome analysis highlights the significant role of gene duplication in social evolution

Neural mechanisms that modulate the motivation for male sexual behaviors ― neuromodulation by co-existing two neuropeptides in the same neuron ―

Reconstruction of extremely large lineage trees by FRACTAL

The function of learning regulating protein is supported by back-up systems using the closely related protein