{"id":52,"date":"2014-06-20T12:50:24","date_gmt":"2014-06-20T03:50:24","guid":{"rendered":"http:\/\/emoto.microwest-test.com\/?page_id=52"},"modified":"2026-04-09T13:12:46","modified_gmt":"2026-04-09T04:12:46","slug":"greeting","status":"publish","type":"page","link":"https:\/\/www.bs.s.u-tokyo.ac.jp\/~brain\/en\/greeting\/","title":{"rendered":"Greeting"},"content":{"rendered":"

GREETING<\/span><\/h3>\n

\"\"This laboratory started in 1877, when The University of Tokyo was established as the Laboratory of Zoology.
\nEver since, it has been the leading biological research institute in Japan, making significant advances in physiology such as (1) the first successful measurement of the membrane potential (2) the discovery of the Ca2+ requirement for the muscle contraction, and (3) the determination of structure and action mechanisms of the cilliary movements.<\/p>\n

140 years after Dr. Edward S. Morse the 1st Professor, Dr. Emoto succeeded this historical and prestigious laboratory as the 10th Professor.
\nWith the brand-new name “Laboratory for Brain Function”, our laboratory continues to advance the understanding of biology, primarily focusing on one of its most enigmatic and exciting aspects – the neuronal mechanisms of “individuality”.<\/p>\n

Biography<\/span><\/h3>\n
\n
1997<\/dt>\n
Received PhD from Graduate School of Phermaceutical Sciences, the University of Tokyo (Prof. Keizo Inoue)<\/dd>\n
1997<\/dt>\n
Research Associate, Tokyo Metropolitan Institute of Medical Sciences (Dr. Umeda)<\/dd>\n
2002<\/dt>\n
Research Associate, University of California San Franscisco (Prof. Yuh-Nung Jan & Lily Jan)<\/dd>\n
2006<\/dt>\n
Independent Associate Professor, National Institute of Genetics Japan<\/dd>\n
2010<\/dt>\n
Group Director, Osaka Bioscience Institute<\/dd>\n
2013<\/dt>\n
Professor, Graduate School of Sciences, The University of Tokyo<\/dd>\n<\/dl>\n

Selected Publications<\/span><\/h3>\n

1. *Tsuji M, Jinkoma D, Uemura Y, Ogasawara A & *Emoto K<\/strong>
\nDopaminergic neurons in the brain orchestrates cardiac and behavioral threat responses.
\neLife<\/strong><\/em> (2026).<\/span><\/p>\n

2. Hemmi C, Motoyoshi M, *Ishii K, Tsuji M & *Emoto K<\/strong>
\nA neuropeptidergic circuitry that modulates developmental sleep in Drosophila.
\neLife<\/strong><\/em>14: PR105710 (2026).<\/span><\/p>\n

3. Yoshino J, Mali S, Williams CR, Morita T, Emerson C, Emerson C, Arp C, Miller S, Yin C, Hemmi C, Motoyoshi M, Ishii K, *Bautista D, *Emoto K<\/strong> & *Parrish JZ
\nDrosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavior outputs.
\neLife<\/strong><\/em> 13: PR95379 (2025).<\/span>
\nDOI: 10.7554\/eLife.95379<\/p>\n

4. Furusawa K, Ishii K, Tsuji M, Tokumitsu N, Hasegawa E & *Emoto K<\/strong>
\nPresynaptic Ube3a E3 ligase promotes synapse elimination through downregulation of BMP signaling.
\nScience<\/strong><\/em> 381: 1197-1205 (2023).<\/span>
\nDOI: 10.1126\/science.ade8978<\/p>\n

5. Tsuji M, Nishizuka Y & *Emoto K<\/strong>
\nThreat gates visual aversion via theta activity in Tachykinergic neurons.
\nNature Communications<\/strong><\/em> 14: 3987 (2023).<\/span>
\nDOI: 10.1038\/s41467-023-39667-z<\/p>\n

6. Nakamizo-Dojo M, Ishii K, Yoshino J, Tsuji M & *Emoto K<\/strong>
\nDescending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating.
\nNature Communications<\/strong><\/em> 14: 6515 (2023).<\/span>
\nDOI: 10.1038\/s41467-023-42202-9<\/p>\n

7. Yoshino J, Morikawa R, Hasegawa E & *Emoto K<\/strong>
\nNeural circuitry that evokes escape behavior upon activation of nociceptive sensory neurons in Drosophila larvae.
\nCurrent Biology<\/strong><\/em> 27: 2499-2504 (2017).<\/span>
\nDOI: 10.1016\/j.cub.2017.06.068<\/p>\n

8. Yasunaga K, Tezuka A, Ishikawa N, Dairyo Y, Togashi K, Koizumi H & *Emoto K<\/strong>
\nAdult Drosophila sensory neurons specify dendrite territories independently of dendritic contacts through the Wnt5-Drl signaling pathway.
\nGenes & Development<\/strong><\/em> 29: 1763-1775 (2015).<\/span>
\nDOI: 10.1101\/gad.262592.115<\/p>\n

9. Kanamori T, Yoshino J, Yasunaga K, Dairyo Y & *Emoto K<\/strong>
\nLocal endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons.
\nNature Communications<\/strong><\/em> 6: 6515 (2015).<\/span>
\nDOI: 10.1038\/ncomms7515<\/p>\n

10. Kanamori T, Kanai M, Dairyo Y, Yasunaga K, Morikawa R & *Emoto K<\/strong>
\nCompartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons.
\nScience<\/strong><\/em> 340: 1475-1478 (2013).<\/span>
\nDOI: 10.1126\/science.1234879<\/p>\n

11. Sakurai A, Koganazawa M, Yasunaga K, Emoto K<\/strong> & *Yamamoto D
\nSelect interneuron clusters determine female choosiness in Drosophila.
\nNature Communications<\/strong><\/em> 4: 1825 (2013).<\/span>
\nDOI: 10.1038\/ncomms2837<\/p>\n

12. Morikawa R, Kanamori T, Yasunaga K & *Emoto K<\/strong>
\nDifferent levels of the TRIM protein Asap regulate distinct axonal projections of Drosophila sensory neurons.
\nProc Natl Acad Sci USA<\/strong><\/em> 108: 19389-19394 (2011).<\/span>
\nDOI: 10.1073\/pnas.1109843108<\/p>\n

13. Yasunaga K, Kanamori T, Morikawa R, Suzuki E & *Emoto K<\/strong>
\nDendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase- mediated modification of the basement membranes.
\nDevelopmental Cell<\/strong><\/em> 18: 621-632 (2010).<\/span>
\nDOI: 10.1016\/j.devcel.2010.02.010<\/p>\n

14. Koike-Kumagai M, Yasunaga K, Morikawa R, Kanamori T & *Emoto K<\/strong>
\nThe target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signaling pathway.
\nEMBO Journal<\/strong><\/em> 28: 3879-3892 (2009).<\/span>
\nDOI: 10.1038\/emboj.2009.312<\/p>\n

15. Soba P, Zhu S, Emoto K<\/strong>, Younger S, Yang SJ, Yu HH, Lee T, Jan LY & *Jan YN
\nDrosophila sensory neurons require Dscam for dendrite self-avoidance and proper dendritic organization.
\nNeuron<\/strong><\/em> 54: 403-416 (2007).<\/span>
\nDOI: 10.1016\/j.neuron.2007.03.029<\/p>\n

16. Parrish JZ, Emoto K<\/strong>, Jan LY & *Jan YN
\nPolycomb genes interact with the tumor suppressor hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
\nGenes & Development<\/strong><\/em> 21: 956-972 (2007).<\/span>
\nDOI: 10.1101\/gad.1514507<\/p>\n

17. Emoto K<\/strong>, Parrish JZ, Jan LY & *Jan YN
\nThe tumour suppressor Hippo acts with the NDR kinases sin dendritic tiling and maintenance.
\nNature<\/strong><\/em> 443: 210-213 (2006).<\/span>
\nDOI: 10.1038\/nature05090<\/p>\n

18. Emoto K<\/strong>, He Y, Ye B, Grueber WB, Adler PN, Jan LY & *Jan YN
\nControl of dendritic branching and tiling by the Tricornered-kinase\/Furry signaling pathway in Drosophila sensory neurons.
\nCell<\/strong><\/em> 119: 245-256 (2004).<\/span>
\nDOI: 10.1016\/j.cell.2004.09.036<\/p>\n

19. Emoto K<\/strong> & *Umeda M
\nAn essential role for a membrane phospholipid in cytokinesis: Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine.
\nJ Cell Biol<\/strong><\/em> 149: 1215-1224 (2000).<\/span><\/p>\n

20. Emoto K<\/strong>, Kuge O, Nishijima M & *Umeda M
\nIsolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine.
\nProc Natl Acad Sci USA<\/strong><\/em> 96: 12400-12405 (1999).<\/span><\/p>\n

21. Emoto K<\/strong>, Kobayashi T, Yamaji A, Aizawa H, Yahara I, Inoue K & *Umeda M
\nRedistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis.
\nProc Natl Acad Sci USA<\/strong><\/em> 93: 12867-12872 (1996).<\/span><\/p>\n

 <\/p>\n

Contact<\/span><\/h3>\n

Emoto Lab for Brain Function
\nDepartment of Biological Sciences
\nGraduate School of Science
\nThe University of Tokyo
\nRoom 151, Faculty of Science Building 2, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 Japan
\nTEL & FAX : 03-5841-4426
\nEmail : emoto[at]bs.s.u-tokyo.ac.jp\uff08replace [at] with \uff20\uff09<\/p>\n

\"\"<\/a><\/p>\n

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