Eukaryotic gene regulation is based on stochastic yet controlled promoter switching, during which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of this process, recent studies reveal a surprising invariance of the "switching correlation time”, which characterizes promoter activity fluctuations. This quantity is constant across gene expression levels in diverse genes and organisms. A biophysically plausible explanation for this invariance remains missing. I will present recent work in collaboration with our experimental colleagues (Gregor lab), which provides mechanistic and functional insights into the origin and meaning of the said invariance.

 

場所：理学部3号館412号室およびZoom

 

学外で参加希望のかたは、info.kuroda-lab@bs.s.u-tokyo.ac.jpまでメールをいただければ、ZoomのURLを送付いたします。所属機関のメールアドレスでお願いいたします。個人のメールアドレスはお控えください。その際には、氏名と所属も合わせてお願いいたします。

理学系研究科 生物科学専攻 生物情報科学科 黒田研究室　 黒田 真也