生物科学セミナー
第1578回生物科学セミナー『Brainstem dynamics gating REM sleep』
| 日時： | 2026年8月3日（月） 16:00-17:30 |
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| 場所： | 理学部2号館201号室 |
| 演者： | Franz Weber, PhD（Department of Neuroscience, Chronobiology Program, Perelman School of Medicine, University of Pennsylvania） |
| 演題： | Brainstem dynamics gating REM sleep |
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要旨
REM sleep is a distinct brain state associated with vivid dreaming, yet how the brain decides when to enter REM sleep remains unclear. I will present recent work from our lab showing that REM sleep is not simply generated by a local on/off switch, but emerges from slow, coordinated population dynamics across a distributed brainstem network. Using high-density Neuropixels recordings in naturally sleeping mice, we found that brainstem activity evolves along low-dimensional trajectories that gradually prepare the brain for REM sleep and predict when REM will occur. These dynamics also determine whether optogenetic activation of REM-promoting neurons successfully triggers a state transition, suggesting that local circuits act within a broader network state. I will also discuss how this framework extends to the organization of REM sleep itself, including tonic and phasic REM substates. Together, these findings suggest that REM sleep is an emergent network state, prepared during non-REM sleep and dynamically structured.
参考文献
1. “Low-dimensional population dynamics in the brainstem gate REM sleep.” David E Lozano , Jiso Hong , Xi Jin , Joseph A Stucynski, Christian K Machens, Shinjae Chung, Franz Weber, Nat Neurosci., 2026 Jul;29(7):1625-1637. doi: 10.1038/s41593-026-02314-z. Epub 2026 May 25.
2. “Prefrontal cortical regulation of REM sleep.” Jiso Hong, David E Lozano, Kevin T Beier, Shinjae Chung, Franz Weber, Nat Neurosci., 2023 Oct;26(10):1820-1832. doi: 10.1038/s41593-023-01398-1. Epub 2023 Sep 21.
3. “Heart rate and sleep history encode ultradian REM sleep timing.” Leilei Hao, Joel Woolley , Zhuowen Yin, Xi Jin, Joseph Stucynski, Raquel Adaia Sandoval Ortega, Gregory Corder, Shinjae Chung, Franz Weber, Curr Biol., 2026 Mar 23;36(6):1422-1434.e5. doi: 10.1016/j.cub.2026.02.034. Epub 2026 Mar 11.
担当
東京大学大学院理学系研究科・生物科学専攻・睡眠生理学研究室
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