In our laboratory, we are investigating how germ cells—the precursors of sperm—acquire the “correct way” to use the information passed down to the next generation. Although DNA sequences are largely identical, the timing and expression of specific genes are strictly regulated. The key to this lies in the “epigenome,” which determines how DNA is read. We focus on the large-scale chromatin reorganization and transposon regulation that occur in germ cells before and after birth. By utilizing cutting-edge genomic analysis and molecular biological techniques, we aim to elucidate the molecular basis that underpins the intergenerational transmission of life.
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