The cells in our body sense environmental changes and respond by secreting signalling molecules, such as neurotransmitters and hormones. These signalling molecules regulate memory, learning and appetite, as well as maintaining physiological homeostasis — the disruption of which can lead to disease.

Recent findings have also revealed that the gut microbiota can influence behaviour by promoting the secretion of these signalling molecules from the intestinal tract.

Our aim is to elucidate the signalling pathways that regulate the secretion of these molecules and the behavioural control mechanisms mediated by the gut microbiota–intestinal tract–brain axis, particularly with regard to cognitive function. We utilise in vivo imaging techniques employing fluorescent protein sensors to achieve this goal.