Graduate School of Science

Faculty of Science

Department of Biological Sciences, Graduate School of Science, The University of Tokyo

Department of Biological Sciences
Graduate School of Science
The University of Tokyo

Graduate School of Science

Faculty of Science

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Labs Sugimura Lab

JP

Core Division / Biophysics and Biochemistry Sugimura Lab Biophysics and Developmental Biology

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Associate Professor Kaoru Sugimura

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Assistant Professor Shinya Matsuda

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Specially Appointed Assistant Professor Toshinori Namba

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Subject of research

  1. 1. Elucidating how mechanics regulate morphogenesis
  2. 2. Developing quantification methods for epithelial mechanics
  3. 3. Understanding the scaling mechanisms of morphogen gradients

Understanding Multicellular Pattern Formation through the Lens of Physics and Statistics

How do cells push and pull each other to trigger precise deformations of a tissue when shaping the body? The answer to this central question is essential for understanding the development of animal forms.

By combining mechanical and genetic perturbations along with live imaging and Bayesian force-inference, we are addressing physical principles underlying regulation of epithelial morphogenesis.

  • Deviatoric stress in Drosophila pupal wing (left) and in mammalian epithelial cells (right)

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