Plants inherently possess strong defense (immune) capabilities against pathogens. By employing genomics, proteomics, and metabolomics approaches, we aim to isolate genes, proteins, and small chemical compounds involved in plant disease resistance and elucidate the plant immune system. Focusing on disease resistance signaling complexes and post-translational modifications of proteins that regulate the immune system, we will uncover dynamic regulatory mechanisms at the protein level. Additionally, using chemical genetics, we will obtain disease-resistant mutants and identify novel genes responsible for resistance. Furthermore, we will investigate the infection mechanisms of parasitic plants and the corresponding immune responses using genome-based approaches.