Department of Biological Sciences, Graduate School of Science, The University of Tokyo

Department of Biological Sciences
Graduate School of Science
The University of Tokyo

Labs Oota Lab

JP

Core Division / Biology Oota Lab Genome Anthropology

Laboratory Website

Professor Hiroki Oota

Assistant Professor Kae Koganebuchi

Specially Appointed Assistant Professor Yusuke Watanabe

Subject of research

  1. 1. Ancient Human Skeletal Genome Analysis
  2. 2. Coprolite Genome Analysis
  3. 3. Sediment DNA Analysis from Archaeological Sites
  4. 4. Omics Analyses Using Jomon iPSC (Induced Pluripotent Stem Cells)

Anthropological Studies Grounded in Ancient Genomics

Our laboratory conducts research aimed at elucidating the processes of human evolution and adaptation at the molecular level, grounded in the field of ancient genomics. Specifically, we analyze DNA extracted from ancient human skeletal remains, coprolites, and sediments from archaeological sites to investigate past population structures, demographic dynamics, dietary patterns, and interactions with pathogens from multiple perspectives.

In addition, we perform omics analyses using induced pluripotent stem cells (iPS cells) that harbor Jomon genomes, comparing their physiological and metabolic characteristics with those of modern human cells to examine gene expression patterns unique to the Jomon people.

Through close collaboration with fields such as archaeology, cultural anthropology, physiological anthropology, primatology, cell biology, and molecular biology, we aim to both advance our understanding of human diversity and pioneer novel research methodologies. We also place strong emphasis on training undergraduate and graduate students in cutting-edge genomic analysis techniques and fostering interdisciplinary thinking.
 
  • Clean room facility for ancient genome analysis newly established in the Faculty of Science Building 2 (left), in silico analysis of genomic data (center), and DNA extraction from ancient human skelet