Proteins have evolved over extensive periods, filling nature with remarkable diversity and surprises. Therefore, understanding the molecular basis underlying their functions offers profound excitement, while successfully modifying these functions to surpass natural capabilities brings immense joy. Our laboratory integrates cryo-electron microscopy, artificial intelligence techniques, electrophysiological methods, and molecular pharmacology approaches to unravel fundamental principles of life, develop innovative biotechnologies, and discover drug leads. Beyond studying known proteins, we actively explore naturally occurring yet untapped functional proteins, elucidate their structural and functional characteristics, and refine them into powerful research tools.