Maintaining homeostasis and understanding the mechanisms of disease onset through the control of ribosome dynamics are crucial areas of study. Damage to protein homeostasis can disrupt a wide range of cellular functions, leading to neurodegenerative diseases and aging. Collisions between ribosomes during translation result in the synthesis of abnormal proteins, which can initiate cell death and inflammatory responses. 
Our research focuses on elucidating the molecular mechanisms involved in quality control that resolves these colliding ribosomes. We aim to uncover the molecular basis for the onset of neurodegenerative diseases, such as ALS, and to understand the mechanisms of aging that result from the breakdown of these processes. Additionally, we are investigating ribosome functions related to mRNA stability, protein folding, and protein localization. Our goal is to clarify the quality control mechanisms of abnormal ribosomes that contribute to the onset of ribosomal diseases. We are also exploring the molecular basis and physiological functions of expression control through translation rate and quality control.