Our laboratory is engaged in the generation and analysis of genetically modified mice to elucidate the molecular mechanisms of brain function, neurodevelopment, and tumorigenesis at the whole-organism level. In particular, the research focuses on the mammalian target of rapamycin (mTOR) signaling pathway and glutamate receptors, both of which are implicated in neurodevelopmental disorders and neurodegeneration. Furthermore, the laboratory has established a gene-targeting method in mice by introducing CRISPR/Cas into fertilized eggs to induce site-specific double-strand breaks in the genome. Using this approach, the laboratory is also generating marmoset models of neuropsychiatric disorders.