Laboratory of Embryology

zeburafish & medakaWe are interested in every aspect of vertebrate development from early axis formation to late organogenesis, such as somitogenesis, dorsoventral patterning and left-right asymmetry. Somitogenesis in zebrafish (Danio rerio) has been one of our main targets for the last decade. In addition to the zebrafish, we introduced the medaka system to our research in 2000. Medaka (Oryzias latipes) is an emerging model vertebrate complimentary to zebrafish, with advantages of a smaller genome, highly polymorphic inbred strains and a wide range of growth permissive temperatures. As expected from the great evolutionarily distance between medaka and zebrafish (more than 110 million years), we now have medaka developmental mutations with unique phenotypes. Having these two excellent model systems, we are analyzing the mechanisms underlying vertebrate development.


Lab members updated.

Publication updated.
Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly.(in press)

Lab members and Publication updated.
Fusion of piggyBac-like transposons and herpesviruses occurs frequently in teleosts
Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos

Publication updated.Unlinking the methylome pattern from nucleotide sequence, revealed by large-scale in vivo genome engineering and methylome editing in medaka fish

We made a press release about the centromere structure of Medaka.

We made a press release about a mobile genetic element of Medaka.

Publication updated. Hypomethylated domain-enriched DNA motifs prepattern the accessible nucleosome organization in teleosts

Our Ph.D course student, Kota Abe (D3) got Poster Award at 50th annual meeting of the JSDB. Congratulations!

Lab members updated.

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