Laboratory of Embryology

zeburafish & medakaWe are interested in every aspect of vertebrate development from early axis formation to late organogenesis, such as somitogenesis, dorsoventral patterning and left-right asymmetry. Somitogenesis in zebrafish (Danio rerio) has been one of our main targets for the last decade. In addition to the zebrafish, we introduced the medaka system to our research in 2000. Medaka (Oryzias latipes) is an emerging model vertebrate complimentary to zebrafish, with advantages of a smaller genome, highly polymorphic inbred strains and a wide range of growth permissive temperatures. As expected from the great evolutionarily distance between medaka and zebrafish (more than 110 million years), we now have medaka developmental mutations with unique phenotypes. Having these two excellent model systems, we are analyzing the mechanisms underlying vertebrate development.


Lab members updated.

Lab members updated.

Publication updated.
・Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite.

Lab members updated.

Our new papers have been published!
・Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly.
・Targeted in vivo epigenome editing of H3K27me3.

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