Research Achievements: The University of Tokyo Global COE Integrative Life Science Based on the Study of Biosignaling Mechanisms

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Research Achievements

JNK regulates the photic response of the mammalian circadian clock.: Yoshitaka Fukada (Department of Biophysics and Biochemistry, Graduate School of Medicine)
Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment.: Nobutaka Hirokawa (Department of Cell Biology and Anatomy, Graduate School of Medicine)
Identification of the molecules regulating plant immune system in membrane trafficking system.: Akihiko Nakano (Department of Biological Sciences, Graduate School of Science)
Identification of a negative regulator of microRNA biogenesis.: Hiroshi I. Suzuki, Kohei Miyazono (Department of Molecular Pathology, Graduate School of Medicine)
IL1RAPL1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with PTPδ.: Masayoshi Mishina (Department of Functional Biology, Graduate School of Medicine)
The role of meiotic recombination in chromosome segregation.: Yoshinori Watanabe (Institute of Molecular Cellular Biosciences)
A critical factor that determines the direction of phototaxis in unicellular green algae.: Ritsu Kamiya (Department of Biological Sciences, Graduate School of Science)
Conserved regulatory mechanisms of chromosome shaping.: Yoshinori Watanabe (Institute of Molecular Cellular Biosciences)
How did plants explore unique intracellular trafficking routes?: Akihiko Nakano (Department of Biological Sciences, Graduate School of Science)
Molecular Motor KIF17 Is Fundamental for Memory and Learning via Differential Support of Synaptic NR2A/2B Levels.: Nobutaka Hirokawa (Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo)
Flexible network dynamics across cortical layers during visual processing and memory retrieval.: Yasushi Miyashita (Department of Physiology, Graduate School of Medicine)
Molecular mechanism underlying the light-dependent resetting of the circadian clock and activation of locomotor activities.: Yoshitaka Fukada (Department of Biophysics and Biochemistry, Graduate School of Science)
Functional modulation of developmental signals by a kinesin molecular motor — KIF16B/Rab14-mediated transport of FGF receptors essential for development of a life.: Nobutaka Hirokawa (Department of Cell Biology and Anatomy, Graduate School of Medicine)
Two histone marks establish the inner centromere and chromosome bi-orientation.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.: Yuichi Iino (Department of Biophysics and Biochemistry, Graduate School of Science)
Protecting preimplantation embryos: a dead Sirt(3).: Hiroki Kurihara (Department of Molecular and Cellular Biology, Graduate School of Medicine)
Scents of direction; neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor source.: Kensaku Mori (Department of Physiology, Graduate School of Medicine)
Elucidation of molecular mechanism of neuronal network formation in the brain.: Masayoshi Mishina (Department of Functional Biology, Graduate School of Medicine)
Shugoshin-PP2A counteracts Casein Kinase 1-dependent cleavage of Rec8 by separase.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Spillover of neurotransmitter glutamate from synapses transition.: Masamitsu Iino (Department of Pharmacology, Graduate School of Medicine)
Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition.: Yukiko Gotoh (Institute of Molecular and Cellular Biosciences)
DYRK1A and GSK-3β: A dual kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.: Yoshitaka Fukada (Department of Biophysics and Biochemistry, Graduate School of Science)
Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Maturation of microRNA is hormonally regulated by a nuclear receptor.: Shigeaki Kato (Institute of Molecular and Cellular Biosciences, The University of Tokyo)
DNA demethylation in hormone-induced transcriptional derepression.: Shigeaki Kato (Institute of Molecular and Cellular Biosciences, The University of Tokyo)
A novel kinesin superfamily protein that controls GDNF-Ret signaling in enteric neuronal development.: Nobutaka Hirokawa (Department of Cell Biology and Anatomy, Graduate School of Medicine)
Molecular mechanism of KIF1A and KIF1Bβ-mediated axonal transport of Rab3-carrying synaptic vesicle precursors.: Nobutaka Hirokawa (Department of Cell Biology and Anatomy, Graduate School of Medicine)
Molecular mechanism how dendrite specific motor KIF17 releases NMDA receptors in an activity-dependent manner.: Nobutaka Hirokawa (Deparment of Cell Biology and Anatomy, Graduate school of medicine)
Translocation of a "Winner" Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of "Losers" from the Soma in Developing Cerebellum.: Masanobu Kano (Department of Neurophysiology, Graduate School of Medicine)
CENP-C functions as a scaffold for essential kinetochore components in mitosis and meiosis.: Yoshinori Watanabe (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo)
Distinct function of two chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF).: Shigeaki Kato (Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.: Yoshitaka Fukada (Department of Biophysics and Biochemistry, Graduate School of Science)
Scaffolding function of PAK in the PDK1-Akt pathway.: Yukiko Gotoh (Institute of Molecular and Cellular Biosciences)
Temporal switching and cell-to-cell variability in Ca²⁺ release activity in mammalian cells.: Masamitsu Iino (Department of Cellular and Molecular Pharmacology, Graduate School of Medicine)
Aberrant E2F Activation by Polyglutamine Expansion of Androgen Receptor in SBMA Neurotoxicity.: Shigeaki Kato (Institute of Molecular and Cellular Biosciences)
Tetsuya Tabata (Institute of Molecular and Cellular Biosciences)
Structural mechanism of the regulation of ADP release from molecular motor kinesin and implication for the kinesin motility.: Nobutaka Hirokawa (Department of Cell Biology & Anatomy, Graduate School of Medicine)
Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT.: Tetsuya Tabata (Institute of Molecular and Cellular Biosciences)
Worms reach the destination using two behavioral patterns.: Yuichi Iino (Department of Biophysics and Biochemistry, Graduate School of Science)
GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.: Shigeaki Kato (Institute of Molecular and Cellular Biosciences, University of Tokyo)
Hepatic stem cells are present in EpCAM⁺ cells of normal and injured mouse liver.: Atsushi Miyajima (Institute of Molecular and Cellular Biosciences)
Kinetochore geometry defined by cohesion within the centromere.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Cognitive set reconfiguration signaled by macaque posterior parietal neurons.: Yasushi Miyashita (Department of Functional Biology, Graduate School of Medicine)
A critical role for constitutive type I interferon signaling in the prevention of cellular transformation.: Tadatsugu Taniguchi (Department of Immunology,Graduate School of Medicine)
A SNARE Complex Unique to Seed Plants Is Required for Protein Storage Vacuole Biogenesis and Seed Development of Arabidopsis thaliana.: Akihiko Nakano (Department of Biological Sciences, Graduate School of Science)
Daily rhythm in hippocampal neurogenesis.: Yoshitaka Fukada (Department of Biophysics and Biochemistry, Graduate School of Science)
Activation of TGF-ß/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts.: Yoshitaka Fukada (Department of Biophysics and Biochemistry, Graduate School of Science)
Identification of a molecular switch determining maxillomandibular morphogenesis.: Hiroki Kurihara (Department of Physiological Chemistry and Metabolism, Graduate School of Medicine)
From a medaka LR mutant to primary ciliary dyskinesia - A novel gene required for cytoplasmic pre-assembly of axonemal dyneins.: Hiroyuki Takeda (Department of Biological Sciences, Graduate School of Science)
Ritsu Kamiya (Department of Biological Sciences, Graduate School of Medicine)
Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
Non-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor system.: Hiroo Fukuda (Department of Biological Sciences, Graduate School of Science)
Heterochromatin protect centromeric cohesion by recruiting shugoshin.: Yoshinori Watanabe (Institute of Molecular and Cellular Biosciences)
PX-RICS, a chauffeur of cadherins —A novel mechanism of protein transport from the ER to the Golgi—: Testsu Akiyama (Institute of Molecular and Cellular Biosciences)
12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.: Takao Shimizu (Department of Biochemistry and Molecular Biology, Faculty of Medicine)
Identification of CASY-1, which is essential for memory formation.: Yuichi Iino (Department of Biophysics and Biochemistry, Graduate School of Science)
Identification and analysis of a cytosolic DNA sensor in the innate immune system.: Tadatsugu Taniguchi (Department of Immunology, Graduate School of Medicine)
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.: Haruo Kasai (Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine)
The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines.: Haruo Kasai (Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine)
Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins.: Takao Shimizu (Department of Biochemistry and Molecular Biology, Faculty of Medicine)
Kid-Mediated Anaphase Chromosome Compaction Safeguards Mouse Early Embryos Against Multinuclear Formation.: Tadashi Yamamoto (Division of Oncology, Institute of Medical Science)
Discovery of a novel lysophospholipid acyltransferase family essential for membrane asymmetry and diversity —Cloning of lysophospholipid acyltransferase genes—: Takao Shimizu (Department of Biochemistry and Molecular Biology, Graduate School of Medicine)
Functional modularization in the odor maps of the olfactory bulb (Nature 450:503-508, 2007): Hitoshi Sakano (Department of Biophysics and Biochemistry, Graduate School of Science)
Kensaku Mori (Department of Functional Biology, Graduate School of Medicine)