第1306回生物科学セミナー

What wakes us: Networked circadian clocks in the brain

Erik Herzog教授(Department of Biology, Washington University, MO USA)

2019年10月10日(木)    17:00-18:30  理学部3号館 326号室   

On a daily basis, organisms must anticipate the challenges of the cycle of light-dark, warm-cold, food and starvation. Circadian clocks are ubiquitous across species and cell types. This talk will review the evidence for intrinsic circadian timing in the neurons and glia of the mammalian brain. The focus will be on how these cells synchronize to each other and to the local light-dark cycle. The latest advances in our ability to record and manipulate gene and protein expression, neuronal and glial activity, real-time recording in vivo and in vitro set the stage for us to map the network of connected circadian clocks in the brain.

References
1) Jones JR, Simon T, Lones L, Herzog ED., “SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System.” J. Neurosci., 38(37): 7986-7995 (2018).
2) Mazuski C, Abel JH, Chen SP, Hermanstyne TO, Jones JR, Simon T, Doyle FJ 3rd, Herzog ED., “Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons.” Neuron, 99(3): 555-563.e5 (2018).