第1272回生物科学セミナー
Epigenetic control of cellular reprogramming in plants
杉本 慶子 チームリーダー（理化学研究所 環境資源科学研究センター）
2019年12月11日(水) 16:50-18:35 理学部2号館 講堂
Plants display remarkable developmental plasticity and regenerate new organs after injury. Local signals produced by wounding trigger organ regeneration but molecular mechanisms underlying this control are still poorly understood1,2. We investigate how wound stress activates a new transcriptional program to initiate cell fate reprograming and how chromatin-based regulation contributes to this transcriptional modification. We have previously identified WOUND INDUCED DEDIFFERENTIATION1-4 as central regulators of cellular reprogramming and have shown how they promote shoot regeneration by inducing downstream target genes3. We have also demonstrated that many of these reprogramming regulators need to be epigenetically repressed by POLYCOMB REPRESSIVE COMPLEX 2 to prevent unscheduled cellular reprogramming in intact plants4. In this talk I will discuss our latest findings on how wound stress modifies the chromatin landscape and permits global transcriptional activation to promote cellular reprogramming.
参考文献
1. Ikeuchi et al. (2019) Annu Rev Plant Biol 70:3.1-3.30
2. Ikeuchi et al. (2016) Development 143:1442-1451
3. Iwase et al. (2017) Plant Cell 29:54-69
4. Ikeuchi and Iwase et al. (2015) Nature Plants 1, 15089
