塩見研公開ラボセミナー

Studying the effect of ageing on the innate immune system by single cell RNA-seq analysis

蓑田 亜希子 博士(理化学研究所 生命医科学研究センター/エピゲノム技術開発ユニット ユニットリーダー)

2019年09月12日(木)    14:00-15:00  理学部3号館 326号室   

Progressive immune dysfunction with age, termed immunosenescence, is a major contributing factor towards morbidity and mortality of the elderly, and a major target for slowing down aging. Immunosenescence is observed with the well-studied adaptive immunity. However, whether immunosenescence occurs with the innate immunity is understudied in comparison. Tissue-resident ILC2s (group 2 innate lymphoid cells) play a central role in orchestrating the type 2 innate inflammation response to parasite infections and tissue repair, and are also known to play a role in pathogenesis of allergies such as asthma. To study the effect of ageing on the type 2 innate immune system, ILC2 was activated at different ages (8 weeks to 80 weeks) by IL-33 injection to the lung, and carried out single cell RNA-seq analysis of the whole lung. Our preliminary analysis suggests immunosenescence may indeed occur with the type 2 innate immune response, observed in multiple immune cells. I report here these findings.