第1287回生物科学セミナー
Visualizing cancer growth in zebrafish
Marina Mione 博士（Department of Cellular, Computational and Integrative Biology (CIBIO) University of Trento, Italy）
2019年06月05日(水) 16:50-18:35 理学部2号館 201号室
As the zebrafish gains consideration as a powerful system to study diseases, its use
in cancer research steadily increases. Cancer occurs naturally in zebrafish and can
be induced with a variety of toxicological, environmental and genetic methods,
making this small vertebrate an extraordinary tool in cancer research. Indeed, no
other vertebrate model offers the molecular toolbox, the superior imaging
capabilities and the discovery power of genetic, chemical and suppressor screens
as the zebrafish. We study early events in cancer, focusing on molecular and
cellular aspects of transformation, clonal expansion and exploitation of host
resources that characterize cancer-initiating cells and cancer stem cells. We have
developed powerful systems to initiate cancer in different organs and stages of
development, with the goal of understanding the mechanisms of transformation,
visualize transformed cells in vivo and establish platforms for genetic and chemical
screens. A number of projects have been developed using these approaches and
will be presented here, including our latest discoveries in melanoma and
glioblastoma models.
