第1227回生物科学セミナー
Circadian roles in ADHD, autophagy and hematopoiesis – insights from zebrafish
Prof. Han Wang（Soochow University Center for Circadian Clocks, China）
2018年07月10日(火) 16:00-17:30 理学部3号館 326号室
The zebrafish (Danio rerio) has figured prominently as a vertebrate model for studying circadian clocks and circadian roles in various life processes. Using several reverse genetic tools including genome-editing techniques TALEN and CRISPR-Cas9, we have generated a library of zebrafish circadian clock mutants. Through characterizing and analyzing these circadian mutants, we have revealed highly conserved circadian functions of these zebrafish clock genes as well as their novel roles in several pathological and physiological processes. My talk will focus on: 1) Per1b’s role in ADHD (Attention Deficit Hyperactivity Disorder), 2) Rev-erbα’s role in autophagy and 3) circadian regulation of hematopoiesis via Ezh2.
References:
Huang et al. (2015) Journal of Neuroscience 35 (6), 2572-2587.
Huang et al. (2016) Autophagy 12 (8),1292-1309.
Zhong et al. (2018) Nucleic Acids Research 46 (7), 3382-3399.
