第1218回生物科学セミナー

Dynamic control of cell identity in the developing neocortex

Prof. Denis Jabaudon(University of Geneva, Switzerland)

2018年05月21日(Mon)    11:00-12:00  理学部2号館 講堂   

During corticogenesis, ventricular zone progenitors sequentially generatedistinct subtypes of excitatory neurons, accounting for the diversity inneocortical cells and the circuits they form. I will discuss recentfindings from my laboratory on the mechanisms controlling acquisition ofneuron-type specific properties, and on input/activity-dependent processwhich control the generation of neuronal diversity during development.

<参考論文>
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3.Telleyet al. (2016) Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. Science351:1443-6.
4.Pouchelonet al. (2014) Modality-specific thalamocorticalinputs instruct the identity of postsynaptic L4 neurons.Nature 511:471-4.