濡木研公開ラボセミナー

Functional Code of Aminoacyl-tRNA Synthetases: Implications for System Development and Future Medicine

Sunghoon Kim博士(Graduate School of Convergence Science and Collage of Pharmacy Seoul National University)

2018年01月18日(Thu)    16:00-16:30  理学部3号館 326号室   

Aminoacyl-tRNA synthetases (ARSs) are known as essential enzymes linking amino acids to tRNAs in the initial stage of protein synthesis. As living organisms get higher degree of complexity, they have acquired additional domains to coordinate protein synthesis with system development. This lecture introduces how these enzymes have evolved to control system development of higher order organisms and how they can be used as a rich source for future medicine that is signified by 4Ps (precision, preventive, predictive and participatory). Functional changes of human ARSs appear to be finely controlled by metamorphosis through proteolysis, splicing and post-translational modifications. Disease-specific mutations, expression and interactions of these enzymes are actively explored to develop new therapeutics and biomarkers.