第1178回生物科学セミナー

Time for circadian medicine: from molecular outputs to better therapeutics

John B. Hogenesch(Cincinnati Children’s Hospital Medical Center)

2017年11月22日(Wed)    15:30-16:40  理学部3号館 326号室   

The past several decades has seen an explosion of growth in mechanistic understanding of circadian clocks in several model organisms including humans. However, translation of that knowledge into actionable medical interventions has been slow to non-existent. Here, I will discuss some of the reasons why this is and our efforts to mitigate this using systems biology approaches. I will talk about our recent progress in understanding the molecular output of the clock in the mouse and humans, including identifying new opportunities for circadian dosing time in improving drug action -- hypothesis-driven, mechanistic circadian medicine. I will talk about our efforts to test these hypothesis prospectively in model organisms and retrospectively in large clinical databases. Finally, I will discuss future opportunities and challenges.

References:
Zhang, Lahens, et al., PNAS, 111(45): 16219-16224, 2014
Anafi et al., PNAS, 114(20): 5312-5317, 2017