第989回 生物科学セミナー
The Molecular Control Embryogenesis ： lnsights from Zebrafish
Alexander F Schier, Ph. D （Professor, Department of Molecular and Cellular Biology, Harvard University）
2014年05月26日(月) 15:00～ 理学部2号館 講堂
According to the British embryologist Lewis Wolpert, “it is not birth, marriage, or death, but gastrulation which is truly the most important time in your life”. During this process, complex inductive interactions and cell rearrangements result in the formation of ectoderm on the outside and mesendoderm on the inside of the embryo.
I will talk about an “old” signal (the morphogen Nodal) that induces mesendoderm and a “new” signal (the motogen Toddler) that moves mesendoderm.
参考文献
1 “Toddler: an embryonic signal that promotes cell movement via Apelin receptors.”
Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF.
Science. 2014 Feb 14;343(6172):1248636.
2 “Morphogen transport.”
Muller P, Rogers KW, Yu SR, Brand M, Schier AF.
Development. 2013 Apr;140(8):1621-38.
3 “Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.” Muller P, Rogers KW, Jordan BM, Lee JS, Robson D, Ramanathan S, Schier AF.
Science. 2012 May 11;336(6082):721-4.
