第1062回生物科学セミナー
Establishing the molecular mechanisms of solute-carrier (SLC) transporters: from snapshots to movies
Dr. David Drew（Centre for Biomembrane Research. Stockholm University）
2015年11月13日(金) 14：00-15：00 理学部3号館 326号室
Crystal structures of small-molecule transporters have shed light on the conformational changes that take place during structural isomerization from outward to inward-facing states. Rather than a simple “rocking” movement of two bundles around a central substrate-binding site, it has become clear that even the most simplistic transporters utilize non rigid-body rearrangements. Here I will present two examples of SLC transporters and their homologues that reveal novel refinements to the basic alternating access model currently shown in most textbooks.
References
1) Nomura N et al. Structure and mechanism of the mammalian fructose transporter GLUT5. Nature. (2015). 526(7573):397-401.
2) Lee C et al. A two-domain elevator mechanism for sodium/proton antiport.
Nature. (2013). 501(7468):573-7.
3) Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.
Hu NJ, Iwata S, Cameron AD, Drew D. Nature. (2011). 478(7369):408-11
