公開ラボセミナーを開催します(Olivier Gascuel 博士、10/18木)

公開ラボセミナー

日時: 201810月18日(木) 10:00-12:00

演者:Olivier Gascuel 博士

   (CNRS and Institut Pasteur, Paris, France)

 演題:  Renewing Felsenstein’s phylogenetic bootstrap in the era of big data

 In this talk I’ll first describe our research and goals at the Institut Pasteur, Paris, and
the new Center for Bioinformatics, Biostatistics and Integrative Biology (C3BI) I’m
heading in the institute. Then, I’ll present a recent work (Lemoine et al., Nature 2018) on
the phylogenetic bootstrap :  
 Felsenstein’s application of the bootstrap method to evolutionary trees is one of the
most cited scientific papers of all time. The bootstrap method, which is based on
resampling and replications, is used extensively to assess the robustness of
phylogenetic inferences. However, increasing numbers of sequences are now available
for a wide variety of species, and phylogenies based on hundreds or thousands of taxa
are becoming routine. With phylogenies of this size Felsenstein’s bootstrap tends to
yield very low supports, especially on deep branches. Here we propose a new version of
the phylogenetic bootstrap in which the presence of inferred branches in replications is
measured using a gradual ‘transfer’ distance rather than the binary presence or
absence index used in Felsenstein’s original version. The resulting supports are higher
and do not induce falsely supported branches. The application of our method to large
mammal, HIV and simulated datasets reveals their phylogenetic signals, whereas
Felsenstein’s bootstrap fails to do so.

場所: 理学部 3号館 412号室

担当: 東京大学大学院理学系研究科・生物科学専攻・岩崎研究室