第1056回生物科学セミナーを開催します(10/30(金) 11:00~ 3号館412講義室)

第1056回 生物科学セミナー

日時: 10月30日(金) 11:00-

演者: Prof. David E. James
         Charles Perkins Centre, School of Molecular Bioscience and School of Medicine, 
           
Sydney University, Australia

演題: Molecular Mapping of Insulin Action and Insulin Resistance

 We have utilized global unbiased phosphoproteomic
analysis of insulin responsive tissues to construct a large scale map of the
insulin regulated signaling network. This has revealed key regulatory nodes
together with novel substrates of major insulin regulated kinases such as Akt.
Using machine learning we have discovered several new Akt substrates that have
revealed novel aspects of insulin action, several of which will be discussed.
We have also applied similar approaches to examine changes in insulin signaling
and the total proteome in adipocytes rendered insulin resistant using a range
of physiological perturbations. These studies have revealed novel insights into
the mechanism of insulin resistance, which appears to involve the induction of
an insulin sensitive pathway in adipocytes that impairs insulin regulated
glucose metabolism.

場所: 理学部 3号館 412号室

担当: 東京大学大学院理学系研究科・生物科学専攻・黒田研究室